The synthesis and pharmacology of some novel excitatory amino acid analogues

Certain amino acids, notably L-glutamate and L-aspartate, are believed to fulfil a role as excitatory neurotransmitters in the mammalian Central Nervous System (CNS). Investigation has revealed the presence of three, and possibly a fourth, type of receptor for such neurotransmitters. These receptors have been named after the most potent and selective agonist of each; thus they are usually referred to as N-methyl-D-aspartate (A1), quisqualate (A2), kainate (A3) and 2-amino, 4-phosphono butyric acid (A4); the designations in brackets being that of the nomenclature of Fagg and Foster.

Name dc:type.qualificationname

phd

Level dc:type.qualificationlevel

doctoral

Grantor dc:publisher.institution

City of London Polytechnic

Year dc:date.issued

1986

Author dc:creator

• Badman, G. T.

• 540 Chemistry & allied sciences
• 610 Medicine & health

Dc Identifier Grantnumber

N/A

OAI identifier oai:identifier

oai:repository.londonmet.ac.uk:3278