{"id":{"repo_id":"london-metro","oai_identifier":"oai:repository.londonmet.ac.uk:2956"},"canonical_url":"https://search.dev.ndltd.org/etd/london-metro/oai:repository.londonmet.ac.uk:2956","repository":{"repo_id":"london-metro","name":"London Metropolitan University","base_url":"https://repository.londonmet.ac.uk/cgi/oai2"},"display":{"title":"Studies of 3-hydroxypyrid-4-ones and related ligands","abstract":"It has been established that the previous synthetic route to 3-benzyloxy-l, 2-dimethylpyrid-4-one and l,2-dimethyl-3-hydroxypyrid-4-one, under the reported conditions, does not lead to their free bases but to their protonated forms. The structures of those pyridones in both free base and protonated forms have been clarified by spectroscopic techniques and a hydroxypridinium structure is proposed for the salts. The direct synthesis of l,2-dimethlyl-3- hydroxyprid-4-one, has also been achieved by Modifying a reported route. Two new, and general synthetic routes have been investigated in a preliminary way. One route involving the reaction of l-bromobutano-2,3-diono with N?-methylbenzamide, has Ied to the recovery of the starting axide and decomposition of the bromo compound. The second route involves the use of pyridine as the starting material. In this study, 1-ethoxycarbonylpiperidene-3,4- diol was synthesised using a previously reported procedure. The oxidation of this diol with Jones' reagent gave a mixture of products, one of which was identified as the desired product, 1-ethoxycarbonylpiperidene-3,4-dione using G.C.-mass spectrometry techniques. ...","abstract_html":"It has been established that the previous synthetic route to 3-benzyloxy-l, 2-dimethylpyrid-4-one and l,2-dimethyl-3-hydroxypyrid-4-one, under the reported conditions, does not lead to their free bases but to their protonated forms. The structures of those pyridones in both free base and protonated forms have been clarified by spectroscopic techniques and a hydroxypridinium structure is proposed for the salts. The direct synthesis of l,2-dimethlyl-3- hydroxyprid-4-one, has also been achieved by Modifying a reported route. Two new, and general synthetic routes have been investigated in a preliminary way. One route involving the reaction of l-bromobutano-2,3-diono with N?-methylbenzamide, has Ied to the recovery of the starting axide and decomposition of the bromo compound. The second route involves the use of pyridine as the starting material. In this study, 1-ethoxycarbonylpiperidene-3,4- diol was synthesised using a previously reported procedure. The oxidation of this diol with Jones' reagent gave a mixture of products, one of which was identified as the desired product, 1-ethoxycarbonylpiperidene-3,4-dione using G.C.-mass spectrometry techniques. ...","abstract_has_math":false,"creators":["Dodd, Azita"],"institution":"Polytechnic of North London","degree_name":"phd","degree_level":"doctoral","degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":1990,"date_issued":"1990-04","date_published":"1990-04","updated_at":"2026-07-24T02:54:27Z","subjects":["570 Life sciences; biology"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier.grantnumber","label":"Dc Identifier Grantnumber","values":["N/A"],"render_values":[{"text":"N/A","href":null,"code":true}]}]},"links":{"outbound_url":null,"outbound_label":null,"outbound_source":null},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.sponsor","label":"Sponsor","values":["London Metropolitan University"]},{"key":"dc:creator","label":"Author","values":["Dodd, Azita"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["1990-04"]},{"key":"dc:date.issued","label":"Date","values":["1990-04"]},{"key":"dc:publisher.department","label":"Dc Publisher Department","values":["School of Human Sciences (SHSC)","Department of Applied Chemistry and Life Sciences"]},{"key":"dc:publisher.institution","label":"Dc Publisher Institution","values":["Polytechnic of North London"]},{"key":"dc:relation.isreferencedby","label":"Dc Relation Isreferencedby","values":["https://repository.londonmet.ac.uk/2956/"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]},{"key":"dc:type.qualificationlevel","label":"Dc Type Qualificationlevel","values":["doctoral"]},{"key":"dc:type.qualificationname","label":"Dc Type Qualificationname","values":["phd"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["570 Life sciences; biology"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.grantnumber","label":"Dc Identifier Grantnumber","values":["N/A"]},{"key":"dc:identifier.uri","label":"Identifier URI","values":["https://repository.londonmet.ac.uk/2956/1/237824.pdf"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["It has been established that the previous synthetic route to 3-benzyloxy-l, 2-dimethylpyrid-4-one and l,2-dimethyl-3-hydroxypyrid-4-one, under the reported conditions, does not lead to their free bases but to their protonated forms. The structures of those pyridones in both free base and protonated forms have been clarified by spectroscopic techniques and a hydroxypridinium structure is proposed for the salts. The direct synthesis of l,2-dimethlyl-3- hydroxyprid-4-one, has also been achieved by Modifying a reported route. Two new, and general synthetic routes have been investigated in a preliminary way. One route involving the reaction of l-bromobutano-2,3-diono with N?-methylbenzamide, has Ied to the recovery of the starting axide and decomposition of the bromo compound. The second route involves the use of pyridine as the starting material. In this study, 1-ethoxycarbonylpiperidene-3,4- diol was synthesised using a previously reported procedure. The oxidation of this diol with Jones' reagent gave a mixture of products, one of which was identified as the desired product, 1-ethoxycarbonylpiperidene-3,4-dione using G.C.-mass spectrometry techniques. ..."]},{"key":"dc:format","label":"Dc Format","values":["text"]},{"key":"dc:title","label":"Title","values":["Studies of 3-hydroxypyrid-4-ones and related ligands"]}]}],"canonical_facts":{"dc:contributor.sponsor":["London Metropolitan University"],"dc:creator":["Dodd, Azita"],"dc:date":["1990-04"],"dc:date.issued":["1990-04"],"dc:description.abstract":["It has been established that the previous synthetic route to 3-benzyloxy-l, 2-dimethylpyrid-4-one and l,2-dimethyl-3-hydroxypyrid-4-one, under the reported conditions, does not lead to their free bases but to their protonated forms. The structures of those pyridones in both free base and protonated forms have been clarified by spectroscopic techniques and a hydroxypridinium structure is proposed for the salts. The direct synthesis of l,2-dimethlyl-3- hydroxyprid-4-one, has also been achieved by Modifying a reported route. Two new, and general synthetic routes have been investigated in a preliminary way. One route involving the reaction of l-bromobutano-2,3-diono with N?-methylbenzamide, has Ied to the recovery of the starting axide and decomposition of the bromo compound. The second route involves the use of pyridine as the starting material. In this study, 1-ethoxycarbonylpiperidene-3,4- diol was synthesised using a previously reported procedure. The oxidation of this diol with Jones' reagent gave a mixture of products, one of which was identified as the desired product, 1-ethoxycarbonylpiperidene-3,4-dione using G.C.-mass spectrometry techniques. ..."],"dc:format":["text"],"dc:identifier.grantnumber":["N/A"],"dc:identifier.uri":["https://repository.londonmet.ac.uk/2956/1/237824.pdf"],"dc:publisher.department":["School of Human Sciences (SHSC)","Department of Applied Chemistry and Life Sciences"],"dc:publisher.institution":["Polytechnic of North London"],"dc:relation.isreferencedby":["https://repository.londonmet.ac.uk/2956/"],"dc:subject":["570 Life sciences; biology"],"dc:title":["Studies of 3-hydroxypyrid-4-ones and related ligands"],"dc:type":["Thesis"],"dc:type.qualificationlevel":["doctoral"],"dc:type.qualificationname":["phd"]},"updated_at":"2026-07-24T02:54:27Z"}