Effect of dietary omega-3 supplementation on plasma phospholipids, neutral lipids fatty acids and antioxidant status of pregnant women with gestational diabetes and their neonates
type: CreativeWork
description: Background: Gestational diabetes mellitus (GDM) has adverse effects on the level of docosahexaenoic acid (DHA) in phospholipids of maternal and cord red blood cells and cord plasma. This finding was of major concern because DHA is vital for maternal wellbeing and health, and for optimal development of foetal brain and retina. GDM is also associated with increased oxidative stress. There is controversy about omega-3 LCPUFA supplementation and oxidative damage. This ambiguity needs to be explored to reveal its role as modulator of oxidative stress in GDM. Specific Aims: To investigate if (1) GDM adversely affects the plasma omega-3 and omega-6 long-chain polyunsaturated fatty acid (LCPUFA) levels in pregnant women. (2) High BMI is associated with adverse plasma fatty acid profile in GDM women. (3) Supplementation with DHA-enriched formula, enhances the level of the nutrient in the GDM women and their neonates. (4) Antioxidant vitamins status is enhanced by DHA-enriched supplementation in GDM women and their newborns. Methods: Women with (n = 142; 72 active-group, 70 placebo) and without gestational diabetes (n = 28; 10 active-group, 18 placebo) were supplemented from the recruitment (at Newham University Hospital, London) until delivery. Both active- and placebo-groups received 2 capsules of either DHA-enriched formula or high oleic acid sunflower seed oil respectively. Each active supplement capsule contained 300 mg of DHA, 42 mg of eicosapentaenoic acid (EPA) and 8.4 mg of AA, and placebo 721 mg of oleic acid. Blood samples taken from the mothers at recruitment and delivery (maternal and cord) were analysed for plasma fatty acid composition and antioxidant vitamins levels. Results: At recruitment, no significant difference was found in the DHA level in plasma phospholipids (CPG, 4.9% vs. 4.4%, P > 0.05) and neutral lipids (CE, 0.9% vs. 0.9%, P > 0.05), (TG, 0.9% vs. 0.9%, P > 0.05) between healthy pregnant and GDM women respectively. When categorized on the basis of…
abstract: Background: Gestational diabetes mellitus (GDM) has adverse effects on the level of docosahexaenoic acid (DHA) in phospholipids of maternal and cord red blood cells and cord plasma. This finding was of major concern because DHA is vital for maternal wellbeing and health, and for optimal development of foetal brain and retina. GDM is also associated with increased oxidative stress. There is controversy about omega-3 LCPUFA supplementation and oxidative damage. This ambiguity needs to be explored to reveal its role as modulator of oxidative stress in GDM. Specific Aims: To investigate if (1) GDM adversely affects the plasma omega-3 and omega-6 long-chain polyunsaturated fatty acid (LCPUFA) levels in pregnant women. (2) High BMI is associated with adverse plasma fatty acid profile in GDM women. (3) Supplementation with DHA-enriched formula, enhances the level of the nutrient in the GDM women and their neonates. (4) Antioxidant vitamins status is enhanced by DHA-enriched supplementation in GDM women and their newborns. Methods: Women with (n = 142; 72 active-group, 70 placebo) and without gestational diabetes (n = 28; 10 active-group, 18 placebo) were supplemented from the recruitment (at Newham University Hospital, London) until delivery. Both active- and placebo-groups received 2 capsules of either DHA-enriched formula or high oleic acid sunflower seed oil respectively. Each active supplement capsule contained 300 mg of DHA, 42 mg of eicosapentaenoic acid (EPA) and 8.4 mg of AA, and placebo 721 mg of oleic acid. Blood samples taken from the mothers at recruitment and delivery (maternal and cord) were analysed for plasma fatty acid composition and antioxidant vitamins levels. Results: At recruitment, no significant difference was found in the DHA level in plasma phospholipids (CPG, 4.9% vs. 4.4%, P > 0.05) and neutral lipids (CE, 0.9% vs. 0.9%, P > 0.05), (TG, 0.9% vs. 0.9%, P > 0.05) between healthy pregnant and GDM women respectively. When categorized on the basis of…
author: Eram, Sofia
keywords: 610 Medicine & health
date published: 2018-04
date modified: 2026-07-24T02:54:27Z
provider: London Metropolitan University
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: London Metropolitan University