Plasma samples were obtained from seven hypertriglyceridemic (>150 mg/dl) chronic renal failure patients before and after regular hemodialysis. The effect of the plasma on the lipolytic activity of bovine milk lipoprotein lipase was investigated. The lipoprotein lipase activity, as measured by release of C14-labeled free fatty acid from triglyceride, was decreased 8-67% when incubated with uremic plasma as compared to the control plasma (44 mg/dl triglyceride). The inhibition noted prior to hemodialysis did not appear to be alleviated by the dialysis but subsequent treatment with an isolated ultrafiltration technique did appear to remove an inhibitory substance as evidenced by a 22-66% inhibition of lipolytic activity by the ultrafiltrate. It is proposed that the triglyceride-lowering effect observed by others subsequent to hemofiltration treatments is a result of the removal of one or more inhibitors of lipoprotein lipase from the plasma of hypertriglyceridemic renal failure patients.
","abstract_html":"<p>Plasma samples were obtained from seven hypertriglyceridemic (>150 mg/dl) chronic renal failure patients before and after regular hemodialysis. The effect of the plasma on the lipolytic activity of bovine milk lipoprotein lipase was investigated. The lipoprotein lipase activity, as measured by release of C<sup>14</sup>-labeled free fatty acid from triglyceride, was decreased 8-67% when incubated with uremic plasma as compared to the control plasma (44 mg/dl triglyceride). The inhibition noted prior to hemodialysis did not appear to be alleviated by the dialysis but subsequent treatment with an isolated ultrafiltration technique did appear to remove an inhibitory substance as evidenced by a 22-66% inhibition of lipolytic activity by the ultrafiltrate. It is proposed that the triglyceride-lowering effect observed by others subsequent to hemofiltration treatments is a result of the removal of one or more inhibitors of lipoprotein lipase from the plasma of hypertriglyceridemic renal failure patients.</p>","abstract_has_math":false,"creators":["Minear, Alisa"],"institution":null,"degree_name":"Master of Science (MS)","degree_level":"Thesis","degree_discipline":"Nutrition","degree_department":null,"school":null,"contributors":["James W. Blankenship","Stewart W. Shankel","Kathleen K. Zolber","Irma B. Vyhmeister","Winston J. Craig"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":1980,"date_issued":"1980-06-01T07:00:00Z","date_published":"1980-06-01T07:00:00Z","updated_at":"2026-07-24T02:54:10Z","subjects":["Hematology","Lipids","Medical Nutrition","Nephrology","Nutrition","Hemodialysis; Lipoprotein Lipase; Acute Kidney Injury"],"languages":["English"],"rights":["This title appears here courtesy of the author, who has granted Loma Linda University a limited, non-exclusive right to make this publication available to the public. The author retains all other copyrights."],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://scholarsrepository.llu.edu/etd/1597","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["James W. Blankenship","Stewart W. Shankel","Kathleen K. Zolber","Irma B. Vyhmeister","Winston J. Craig"]},{"key":"dc:creator","label":"Author","values":["Minear, Alisa"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"thesis:degree_discipline","label":"Discipline","values":["Nutrition"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Thesis"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Master of Science (MS)"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Hematology","Lipids","Medical Nutrition","Nephrology","Nutrition","Hemodialysis; Lipoprotein Lipase; Acute Kidney Injury"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["English"]},{"key":"dc:rights","label":"Dc Rights","values":["This title appears here courtesy of the author, who has granted Loma Linda University a limited, non-exclusive right to make this publication available to the public. The author retains all other copyrights."]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://scholarsrepository.llu.edu/etd/1597"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Plasma samples were obtained from seven hypertriglyceridemic (>150 mg/dl) chronic renal failure patients before and after regular hemodialysis. The effect of the plasma on the lipolytic activity of bovine milk lipoprotein lipase was investigated. The lipoprotein lipase activity, as measured by release of C14-labeled free fatty acid from triglyceride, was decreased 8-67% when incubated with uremic plasma as compared to the control plasma (44 mg/dl triglyceride). The inhibition noted prior to hemodialysis did not appear to be alleviated by the dialysis but subsequent treatment with an isolated ultrafiltration technique did appear to remove an inhibitory substance as evidenced by a 22-66% inhibition of lipolytic activity by the ultrafiltrate. It is proposed that the triglyceride-lowering effect observed by others subsequent to hemofiltration treatments is a result of the removal of one or more inhibitors of lipoprotein lipase from the plasma of hypertriglyceridemic renal failure patients.
"]},{"key":"dc:title","label":"Title","values":["Lipoprotein Lipase Inhibitor Removal During Ultrafiltration of Renal Failure Patients"]}]}],"canonical_facts":{"dc:contributor":["James W. Blankenship","Stewart W. Shankel","Kathleen K. Zolber","Irma B. Vyhmeister","Winston J. Craig"],"dc:creator":["Minear, Alisa"],"dc:description.abstract":["Plasma samples were obtained from seven hypertriglyceridemic (>150 mg/dl) chronic renal failure patients before and after regular hemodialysis. The effect of the plasma on the lipolytic activity of bovine milk lipoprotein lipase was investigated. The lipoprotein lipase activity, as measured by release of C14-labeled free fatty acid from triglyceride, was decreased 8-67% when incubated with uremic plasma as compared to the control plasma (44 mg/dl triglyceride). The inhibition noted prior to hemodialysis did not appear to be alleviated by the dialysis but subsequent treatment with an isolated ultrafiltration technique did appear to remove an inhibitory substance as evidenced by a 22-66% inhibition of lipolytic activity by the ultrafiltrate. It is proposed that the triglyceride-lowering effect observed by others subsequent to hemofiltration treatments is a result of the removal of one or more inhibitors of lipoprotein lipase from the plasma of hypertriglyceridemic renal failure patients.
"],"dc:identifier":["https://scholarsrepository.llu.edu/etd/1597"],"dc:language":["English"],"dc:rights":["This title appears here courtesy of the author, who has granted Loma Linda University a limited, non-exclusive right to make this publication available to the public. The author retains all other copyrights."],"dc:subject":["Hematology","Lipids","Medical Nutrition","Nephrology","Nutrition","Hemodialysis; Lipoprotein Lipase; Acute Kidney Injury"],"dc:title":["Lipoprotein Lipase Inhibitor Removal During Ultrafiltration of Renal Failure Patients"],"thesis:degree_discipline":["Nutrition"],"thesis:degree_level":["Thesis"],"thesis:degree_name":["Master of Science (MS)"]},"updated_at":"2026-07-24T02:54:10Z"}