{"id":{"repo_id":"loma-linda","oai_identifier":"oai:scholarsrepository.llu.edu:etd-2271"},"canonical_url":"https://search.dev.ndltd.org/etd/loma-linda/oai:scholarsrepository.llu.edu:etd-2271","repository":{"repo_id":"loma-linda","name":"Loma Linda University","base_url":"https://scholarsrepository.llu.edu/do/oai/"},"display":{"title":"Cardioregulatory Role of the Abdominal Ganglion of APLYSIA CALIFORNICA","abstract":"<p>An isolated heart-abdominal ganglion preparation of this mollusc was developed and used to study the cardioregulatory function of the ganglion and nerves. The heart was perfused with artificial sea water through an atrial cannula and the gastro-esophageal artery was catheterized for blood pressure monitoring. The presence and cardioregulatory effects of axons in the nerves was investigated by electrical stimulation. Fine-tipped glass microelectrodes inserted into ganglionic neurons were used to determine the relationship between the neuronal and cardiac activities.</p> <p>The principal results are listed below.</p> <ol> <li>Primarily inhibitory responses are obtained from both right and left connective stimulation, with some evidence for excitatory axons.</li> <li>The siphon nerve exerts a strong inhibitory influence on the heart, probably acting as part of a feedback pathway.</li> <li>Predominantly acceleratory responses are elicited from pericardial nerve stimulation (confirming work of Wright, 1960, and Carlson, 1905).</li> <li>A high frequency spike burst in L7 precedes bradycardia, a coincidental but not deterministic relationship obtained from one subject.</li> <li>Preliminary evidence indicates the presence of a nondeterministic inhibition of long duration in cell L10 associated with bradycardia.</li> <li>There is speculative evidence for inhibitory axons in the genital nerve.</li> </ol>","abstract_html":"&lt;p&gt;An isolated heart-abdominal ganglion preparation of this mollusc was developed and used to study the cardioregulatory function of the ganglion and nerves. The heart was perfused with artificial sea water through an atrial cannula and the gastro-esophageal artery was catheterized for blood pressure monitoring. The presence and cardioregulatory effects of axons in the nerves was investigated by electrical stimulation. Fine-tipped glass microelectrodes inserted into ganglionic neurons were used to determine the relationship between the neuronal and cardiac activities.&lt;/p&gt; &lt;p&gt;The principal results are listed below.&lt;/p&gt; &lt;ol&gt; &lt;li&gt;Primarily inhibitory responses are obtained from both right and left connective stimulation, with some evidence for excitatory axons.&lt;/li&gt; &lt;li&gt;The siphon nerve exerts a strong inhibitory influence on the heart, probably acting as part of a feedback pathway.&lt;/li&gt; &lt;li&gt;Predominantly acceleratory responses are elicited from pericardial nerve stimulation (confirming work of Wright, 1960, and Carlson, 1905).&lt;/li&gt; &lt;li&gt;A high frequency spike burst in L7 precedes bradycardia, a coincidental but not deterministic relationship obtained from one subject.&lt;/li&gt; &lt;li&gt;Preliminary evidence indicates the presence of a nondeterministic inhibition of long duration in cell L10 associated with bradycardia.&lt;/li&gt; &lt;li&gt;There is speculative evidence for inhibitory axons in the genital nerve.&lt;/li&gt; &lt;/ol&gt;","abstract_has_math":false,"creators":["Maeda, George"],"institution":null,"degree_name":"Master of Science (MS)","degree_level":"Thesis","degree_discipline":"Physiology","degree_department":null,"school":null,"contributors":["Bernell E. Baldwin","Kenneth A. Arendt","Elwood S. McCluskey"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":1971,"date_issued":"1971-06-01T07:00:00Z","date_published":"1971-06-01T07:00:00Z","updated_at":"2026-07-24T02:54:01Z","subjects":["Animal Experimentation and Research","Biological Phenomena, Cell Phenomena, and Immunity","Circulatory and Respiratory Physiology","Laboratory and Basic Science Research","Neurosciences","Physiology","Heart -- physiology; Aplysia -- physiology"],"languages":["English"],"rights":["This title appears here courtesy of the author, who has granted Loma Linda University a limited, non-exclusive right to make this publication available to the public. The author retains all other copyrights."],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://scholarsrepository.llu.edu/etd/1495","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Bernell E. Baldwin","Kenneth A. Arendt","Elwood S. 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The author retains all other copyrights."]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://scholarsrepository.llu.edu/etd/1495"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["<p>An isolated heart-abdominal ganglion preparation of this mollusc was developed and used to study the cardioregulatory function of the ganglion and nerves. The heart was perfused with artificial sea water through an atrial cannula and the gastro-esophageal artery was catheterized for blood pressure monitoring. The presence and cardioregulatory effects of axons in the nerves was investigated by electrical stimulation. Fine-tipped glass microelectrodes inserted into ganglionic neurons were used to determine the relationship between the neuronal and cardiac activities.</p> <p>The principal results are listed below.</p> <ol> <li>Primarily inhibitory responses are obtained from both right and left connective stimulation, with some evidence for excitatory axons.</li> <li>The siphon nerve exerts a strong inhibitory influence on the heart, probably acting as part of a feedback pathway.</li> <li>Predominantly acceleratory responses are elicited from pericardial nerve stimulation (confirming work of Wright, 1960, and Carlson, 1905).</li> <li>A high frequency spike burst in L7 precedes bradycardia, a coincidental but not deterministic relationship obtained from one subject.</li> <li>Preliminary evidence indicates the presence of a nondeterministic inhibition of long duration in cell L10 associated with bradycardia.</li> <li>There is speculative evidence for inhibitory axons in the genital nerve.</li> </ol>"]},{"key":"dc:title","label":"Title","values":["Cardioregulatory Role of the Abdominal Ganglion of APLYSIA CALIFORNICA"]}]}],"canonical_facts":{"dc:contributor":["Bernell E. Baldwin","Kenneth A. Arendt","Elwood S. McCluskey"],"dc:creator":["Maeda, George"],"dc:description.abstract":["<p>An isolated heart-abdominal ganglion preparation of this mollusc was developed and used to study the cardioregulatory function of the ganglion and nerves. The heart was perfused with artificial sea water through an atrial cannula and the gastro-esophageal artery was catheterized for blood pressure monitoring. The presence and cardioregulatory effects of axons in the nerves was investigated by electrical stimulation. Fine-tipped glass microelectrodes inserted into ganglionic neurons were used to determine the relationship between the neuronal and cardiac activities.</p> <p>The principal results are listed below.</p> <ol> <li>Primarily inhibitory responses are obtained from both right and left connective stimulation, with some evidence for excitatory axons.</li> <li>The siphon nerve exerts a strong inhibitory influence on the heart, probably acting as part of a feedback pathway.</li> <li>Predominantly acceleratory responses are elicited from pericardial nerve stimulation (confirming work of Wright, 1960, and Carlson, 1905).</li> <li>A high frequency spike burst in L7 precedes bradycardia, a coincidental but not deterministic relationship obtained from one subject.</li> <li>Preliminary evidence indicates the presence of a nondeterministic inhibition of long duration in cell L10 associated with bradycardia.</li> <li>There is speculative evidence for inhibitory axons in the genital nerve.</li> </ol>"],"dc:identifier":["https://scholarsrepository.llu.edu/etd/1495"],"dc:language":["English"],"dc:rights":["This title appears here courtesy of the author, who has granted Loma Linda University a limited, non-exclusive right to make this publication available to the public. The author retains all other copyrights."],"dc:subject":["Animal Experimentation and Research","Biological Phenomena, Cell Phenomena, and Immunity","Circulatory and Respiratory Physiology","Laboratory and Basic Science Research","Neurosciences","Physiology","Heart -- physiology; Aplysia -- physiology"],"dc:title":["Cardioregulatory Role of the Abdominal Ganglion of APLYSIA CALIFORNICA"],"thesis:degree_discipline":["Physiology"],"thesis:degree_level":["Thesis"],"thesis:degree_name":["Master of Science (MS)"]},"updated_at":"2026-07-24T02:54:01Z"}