The effect of a high unsaturated-low saturated fat diet on serum cholesterol levels were studied. Subjects were clinic patients receiving the following hypocholesterolmeic agents: triparanol (MER-29), diildothyroacetic acid (Diac), dextrothyroxine (d-T4) and 3-methoxy-16, alpha-methyl-1,3,5, (10)-estratriene-16 beta, 17 beta-diol (Manvene or Anvene).
Fifteen hypercholesterolemic patients, eleven of whom were diabetic, were placed on diets with prescribed amounts of unsaturated fat. The caloric distribution was 40 per cent carbohydrate, 20 per cent protein, and 40 per cent fat. The level of unsaturated fat was 70 per cent of the total fat.
Seventy-one per cent of the patients on the hypocholesterolemic agents had an overall decrease in serum cholesterol. There was an overall increase in serum cholesterol in 85.5 per cent of the patients not on drug therapy. There was no significant change observed in weight, serum glucose, or serum cholesterol.
Using serum cholesterol as the main criterion for evaluating the efficacy of the diet, the results of this study do not appear to be significant.
","abstract_html":"<p>The effect of a high unsaturated-low saturated fat diet on serum cholesterol levels were studied. Subjects were clinic patients receiving the following hypocholesterolmeic agents: triparanol (MER-29), diildothyroacetic acid (Diac), dextrothyroxine (d-T<sub>4</sub>) and 3-methoxy-16, alpha-methyl-1,3,5, (10)-estratriene-16 beta, 17 beta-diol (Manvene or Anvene).</p> <p>Fifteen hypercholesterolemic patients, eleven of whom were diabetic, were placed on diets with prescribed amounts of unsaturated fat. The caloric distribution was 40 per cent carbohydrate, 20 per cent protein, and 40 per cent fat. The level of unsaturated fat was 70 per cent of the total fat.</p> <p>Seventy-one per cent of the patients on the hypocholesterolemic agents had an overall decrease in serum cholesterol. There was an overall increase in serum cholesterol in 85.5 per cent of the patients not on drug therapy. There was no significant change observed in weight, serum glucose, or serum cholesterol.</p> <p>Using serum cholesterol as the main criterion for evaluating the efficacy of the diet, the results of this study do not appear to be significant.</p>","abstract_has_math":false,"creators":["Hatley, Yvonne Marie"],"institution":null,"degree_name":"Master of Science (MS)","degree_level":"Thesis","degree_discipline":"Nutrition","degree_department":null,"school":null,"contributors":["Phyllis Acosta","Ruth Little","Burt Cochran","U. D. Register","Irma Vyhmeister"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":1961,"date_issued":"1961-06-01T07:00:00Z","date_published":"1961-06-01T07:00:00Z","updated_at":"2026-07-24T02:54:01Z","subjects":["Biochemical Phenomena, Metabolism, and Nutrition","Dietetics and Clinical Nutrition","Endocrinology, Diabetes, and Metabolism","Nutrition","Fats; Unsaturated Cholesterol; Dietary; Anticholesteremic Agents"],"languages":["English"],"rights":["This title appears here courtesy of the author, who has granted Loma Linda University a limited, non-exclusive right to make this publication available to the public. The author retains all other copyrights."],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://scholarsrepository.llu.edu/etd/1467","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Phyllis Acosta","Ruth Little","Burt Cochran","U. D. Register","Irma Vyhmeister"]},{"key":"dc:creator","label":"Author","values":["Hatley, Yvonne Marie"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"thesis:degree_discipline","label":"Discipline","values":["Nutrition"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Thesis"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Master of Science (MS)"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Biochemical Phenomena, Metabolism, and Nutrition","Dietetics and Clinical Nutrition","Endocrinology, Diabetes, and Metabolism","Nutrition","Fats; Unsaturated Cholesterol; Dietary; Anticholesteremic Agents"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["English"]},{"key":"dc:rights","label":"Dc Rights","values":["This title appears here courtesy of the author, who has granted Loma Linda University a limited, non-exclusive right to make this publication available to the public. The author retains all other copyrights."]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://scholarsrepository.llu.edu/etd/1467"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["The effect of a high unsaturated-low saturated fat diet on serum cholesterol levels were studied. Subjects were clinic patients receiving the following hypocholesterolmeic agents: triparanol (MER-29), diildothyroacetic acid (Diac), dextrothyroxine (d-T4) and 3-methoxy-16, alpha-methyl-1,3,5, (10)-estratriene-16 beta, 17 beta-diol (Manvene or Anvene).
Fifteen hypercholesterolemic patients, eleven of whom were diabetic, were placed on diets with prescribed amounts of unsaturated fat. The caloric distribution was 40 per cent carbohydrate, 20 per cent protein, and 40 per cent fat. The level of unsaturated fat was 70 per cent of the total fat.
Seventy-one per cent of the patients on the hypocholesterolemic agents had an overall decrease in serum cholesterol. There was an overall increase in serum cholesterol in 85.5 per cent of the patients not on drug therapy. There was no significant change observed in weight, serum glucose, or serum cholesterol.
Using serum cholesterol as the main criterion for evaluating the efficacy of the diet, the results of this study do not appear to be significant.
"]},{"key":"dc:title","label":"Title","values":["Effect of Isocaloric Unsaturated Fats on Serum Cholesterol of Patients Treated with Hypocholesterolemic Agents"]}]}],"canonical_facts":{"dc:contributor":["Phyllis Acosta","Ruth Little","Burt Cochran","U. D. Register","Irma Vyhmeister"],"dc:creator":["Hatley, Yvonne Marie"],"dc:description.abstract":["The effect of a high unsaturated-low saturated fat diet on serum cholesterol levels were studied. Subjects were clinic patients receiving the following hypocholesterolmeic agents: triparanol (MER-29), diildothyroacetic acid (Diac), dextrothyroxine (d-T4) and 3-methoxy-16, alpha-methyl-1,3,5, (10)-estratriene-16 beta, 17 beta-diol (Manvene or Anvene).
Fifteen hypercholesterolemic patients, eleven of whom were diabetic, were placed on diets with prescribed amounts of unsaturated fat. The caloric distribution was 40 per cent carbohydrate, 20 per cent protein, and 40 per cent fat. The level of unsaturated fat was 70 per cent of the total fat.
Seventy-one per cent of the patients on the hypocholesterolemic agents had an overall decrease in serum cholesterol. There was an overall increase in serum cholesterol in 85.5 per cent of the patients not on drug therapy. There was no significant change observed in weight, serum glucose, or serum cholesterol.
Using serum cholesterol as the main criterion for evaluating the efficacy of the diet, the results of this study do not appear to be significant.
"],"dc:identifier":["https://scholarsrepository.llu.edu/etd/1467"],"dc:language":["English"],"dc:rights":["This title appears here courtesy of the author, who has granted Loma Linda University a limited, non-exclusive right to make this publication available to the public. The author retains all other copyrights."],"dc:subject":["Biochemical Phenomena, Metabolism, and Nutrition","Dietetics and Clinical Nutrition","Endocrinology, Diabetes, and Metabolism","Nutrition","Fats; Unsaturated Cholesterol; Dietary; Anticholesteremic Agents"],"dc:title":["Effect of Isocaloric Unsaturated Fats on Serum Cholesterol of Patients Treated with Hypocholesterolemic Agents"],"thesis:degree_discipline":["Nutrition"],"thesis:degree_level":["Thesis"],"thesis:degree_name":["Master of Science (MS)"]},"updated_at":"2026-07-24T02:54:01Z"}