The Effectiveness of Camphorated Paramonochlorophenol, Metacresyl Acetate, and Prednisolone in Combination as an Antimicrobial Agent

<p>Post-treatment discomfort following endodontic procedures can be caused by inflammation due to injudicious use of intracanal medicaments. Camphorated paramonochlorophenol, metacresyl acetate, and prednisolone in combination is advocated to reduce the inflammatory potential of the germicide and thus reduce the occurrence of post-operative pain. It is imperative that a medicament retain antimicrobial activity while reducing inflammatory potential.</p> <p>This investigation was undertaken toward determining on an in vitro quantitative bactericidal versus bacteriostatic basis by use of the broth dilution test tube method whether camphorated paramonochlorophenol, metacresyl acetate, and prednisolone in combination retains antimicrobial activity comparable to selected other commonly used nonspecific germicides. Four drugs--camphorated paramonochlorophenol (CMC), metacresyl acetate (Cresatin), camphorated paramonochlorophenol and metacresyl acetate in combination (XP-7) and camphorated paramonochlorophenol, metacresyl acetate and prednisolone in combination (CMP)--were tested against seven organisms: <em>Candida albicans</em>, <em>Escherichia coli,</em> <em>Nocardia asteroides</em>, <em>Staphylococcus aureus</em>, <em>Streptococcus salivarius</em>, <em>Streptococcus faecalis</em>, and <em>Clostridium perfringens</em>.</p> <p>Based upon a statistical analysis, the following conclusions were made:</p> <ol> <li>There was no significant difference in the effectiveness of CMP compared to CMC and XP-7</li> <li>The addition of prednisolone to the non-specific germicide made no significant difference in the effectiveness of the drug as an antimicrobial agent.</li> <li>Cresatin was significantly less effective than CMC, XP-7, and CMP at the levels and dilutions used against the spectrum of microorganisms in this study.</li> <li><em>Streptococcus faecalis</em> was the most resistant organism with <em>Staphylococcus aureus</em> slightly more resistant than the remaining organisms.</li> </ol>

Name thesis:degree_name

Master of Science (MS)

Level thesis:degree_level

Thesis

Year

1970

Author dc:creator

• Cutler, Maurice

Contributors dc:contributor

• Ronald E. Buell
• Judson Klooster
• Edwin B. Nutting
• W. Eugene Rathbum
• Charles E. Winters

• Bacteriology
• Dental Materials
• Endodontics and Endodontology
• Oral Biology and Oral Pathology
• Dental Materials; Endodontics

Statement dc:rights

• This title appears here courtesy of the author, who has granted Loma Linda University a limited, non-exclusive right to make this publication available to the public. The author retains all other copyrights.

Language dc:language

English

Repository record dc:identifier

https://scholarsrepository.llu.edu/etd/1457

OAI identifier oai:identifier

oai:scholarsrepository.llu.edu:etd-2229