The periapical tissue reaction to three concentrations of endotoxin solutions and to a sterile saline control solution was examined in six adult cats. The maxillary and mandibular cuspids were isolated and the pulps extirpated with barbed broaches. The four solutions (1, 10, 100 μg/ml endotoxin, and saline) were then injected into the four prepared teeth for each cat and the access cavities sealed with IRM.
At two week intervals, two cats were sacrificed and the specimens removed, while the remaining animals were retreated as previously described. The block tissue sections were radiographed, fixed in 10% buffered formalin, and prepared for histopathologic examination.
The radiographic lesions were ranked according to size and the ordinal data used in the Friedman and Wilcoxon statistical tests. The histologic sections were examined for type of inflammatory cell infiltrate, degree of inflammation, and osteoclastic activity. The histologic observations were used in a descriptive manner, while the radiographic findings were used for comparison of treatment results.
The radiographic results indicated that there was a significant difference between treatments, when measured by ranking radiolucent lesion size (P
","abstract_html":"<p>The periapical tissue reaction to three concentrations of endotoxin solutions and to a sterile saline control solution was examined in six adult cats. The maxillary and mandibular cuspids were isolated and the pulps extirpated with barbed broaches. The four solutions (1, 10, 100 μg/ml endotoxin, and saline) were then injected into the four prepared teeth for each cat and the access cavities sealed with IRM.</p> <p>At two week intervals, two cats were sacrificed and the specimens removed, while the remaining animals were retreated as previously described. The block tissue sections were radiographed, fixed in 10% buffered formalin, and prepared for histopathologic examination.</p> <p>The radiographic lesions were ranked according to size and the ordinal data used in the Friedman and Wilcoxon statistical tests. The histologic sections were examined for type of inflammatory cell infiltrate, degree of inflammation, and osteoclastic activity. The histologic observations were used in a descriptive manner, while the radiographic findings were used for comparison of treatment results.</p> <p>The radiographic results indicated that there was a significant difference between treatments, when measured by ranking radiolucent lesion size (P</p>","abstract_has_math":false,"creators":["Dwyer, Thomas G."],"institution":null,"degree_name":"Master of Science (MS)","degree_level":"Thesis","degree_discipline":"Dentistry","degree_department":null,"school":null,"contributors":["Mahmoud Torabinejad","Leif K. Bakland","William Jarvis","Gordon M. Rick","Grenith J. Zimmerman"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":1979,"date_issued":"1979-06-01T07:00:00Z","date_published":"1979-06-01T07:00:00Z","updated_at":"2026-07-24T02:53:44Z","subjects":["Animal Experimentation and Research","Endodontics and Endodontology","Laboratory and Basic Science Research","Radiology","Endotoxins"],"languages":["English"],"rights":["This title appears here courtesy of the author, who has granted Loma Linda University a limited, non-exclusive right to make this publication available to the public. The author retains all other copyrights."],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://scholarsrepository.llu.edu/etd/1417","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Mahmoud Torabinejad","Leif K. Bakland","William Jarvis","Gordon M. Rick","Grenith J. Zimmerman"]},{"key":"dc:creator","label":"Author","values":["Dwyer, Thomas G."]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"thesis:degree_discipline","label":"Discipline","values":["Dentistry"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Thesis"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Master of Science (MS)"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Animal Experimentation and Research","Endodontics and Endodontology","Laboratory and Basic Science Research","Radiology","Endotoxins"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["English"]},{"key":"dc:rights","label":"Dc Rights","values":["This title appears here courtesy of the author, who has granted Loma Linda University a limited, non-exclusive right to make this publication available to the public. The author retains all other copyrights."]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://scholarsrepository.llu.edu/etd/1417"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["The periapical tissue reaction to three concentrations of endotoxin solutions and to a sterile saline control solution was examined in six adult cats. The maxillary and mandibular cuspids were isolated and the pulps extirpated with barbed broaches. The four solutions (1, 10, 100 μg/ml endotoxin, and saline) were then injected into the four prepared teeth for each cat and the access cavities sealed with IRM.
At two week intervals, two cats were sacrificed and the specimens removed, while the remaining animals were retreated as previously described. The block tissue sections were radiographed, fixed in 10% buffered formalin, and prepared for histopathologic examination.
The radiographic lesions were ranked according to size and the ordinal data used in the Friedman and Wilcoxon statistical tests. The histologic sections were examined for type of inflammatory cell infiltrate, degree of inflammation, and osteoclastic activity. The histologic observations were used in a descriptive manner, while the radiographic findings were used for comparison of treatment results.
The radiographic results indicated that there was a significant difference between treatments, when measured by ranking radiolucent lesion size (P
"]},{"key":"dc:title","label":"Title","values":["The Effect of ESCHERICHIA COLI Endotoxin on the Cat Periapical Tissues"]}]}],"canonical_facts":{"dc:contributor":["Mahmoud Torabinejad","Leif K. Bakland","William Jarvis","Gordon M. Rick","Grenith J. Zimmerman"],"dc:creator":["Dwyer, Thomas G."],"dc:description.abstract":["The periapical tissue reaction to three concentrations of endotoxin solutions and to a sterile saline control solution was examined in six adult cats. The maxillary and mandibular cuspids were isolated and the pulps extirpated with barbed broaches. The four solutions (1, 10, 100 μg/ml endotoxin, and saline) were then injected into the four prepared teeth for each cat and the access cavities sealed with IRM.
At two week intervals, two cats were sacrificed and the specimens removed, while the remaining animals were retreated as previously described. The block tissue sections were radiographed, fixed in 10% buffered formalin, and prepared for histopathologic examination.
The radiographic lesions were ranked according to size and the ordinal data used in the Friedman and Wilcoxon statistical tests. The histologic sections were examined for type of inflammatory cell infiltrate, degree of inflammation, and osteoclastic activity. The histologic observations were used in a descriptive manner, while the radiographic findings were used for comparison of treatment results.
The radiographic results indicated that there was a significant difference between treatments, when measured by ranking radiolucent lesion size (P
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