Augmentation of Natural Killer Cell Activity by CORYNEBACTERIUM PARVUM: Involvement of Lipoxygenase Pathway

<p>The ⁵¹Chromium release assay was used to measure natural killer (NK) cell activity associated with <em>Corynebacterium parvum</em> (CP) injection against YAC-1 and MBT-2 targets. The peritoneal exudate cells from intraperitoneal treatment of CP at different dosages consistently gave higher cytotoxicity than their respective spleen cell fractions. In contrast, CP given intravenously showed the reversed effect. Our results demonstrate that the route of administration and dosage of CP are two crucial variables for determining the effectiveness of this immunostimulant. <em>In vitro</em> manipulations of nordihydroguaiaretic acid, indomethacin, and prostaglandin E2 on CP-stimulated NK cells suggest that the lipoxygenase pathway is involved in NK lysis.</p>

Name thesis:degree_name

Master of Science (MS)

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Microbiology

Year

1986

Author dc:creator

• Kuo, Gregory D.

Contributors dc:contributor

• Benjamin H. S. Lau
• James D. Kettering
• Robert W. Teel

• Microbiology
• Killer Cells, Natural; Propionibacterium acnes; Immunotherapy

Statement dc:rights

• This title appears here courtesy of the author, who has granted Loma Linda University a limited, non-exclusive right to make this publication available to the public. The author retains all other copyrights.

Language dc:language

English

Repository record dc:identifier

https://scholarsrepository.llu.edu/etd/1401

OAI identifier oai:identifier

oai:scholarsrepository.llu.edu:etd-2172