Coronary Heart Disease Mortality and long-term Exposure to Ambient Particulate Air Pollutants in Elderly Nonsmoking California Residents

<p>The purpose of this study is to assess the effect of long-term concentrations of ambient PM on risks of all causes, cardiopulmonary, coronary heart disease (CHD), total cancer, and any mention of nonmalignant respiratory disease (NMRD) mortality.</p> <p>The health effects of long-term ambient air pollution have been studied with up to 30 years of follow-up in the AHSMOG cohort, a cohort of 6,338 nonsmoking white California adults. Monthly concentrations of ambient air pollutants [particulate matter(PMio), Ozone (O3), sulfur dioxide (SO2), nitrogen dioxide (NO2) or particulate matter</p> <p>In the AHSMOG cohort, each increment of 10 |ig/m3 in PMio in two-pollutant models showed increased risks of fatal NMRD with the relative risk (RR) of 1.13 [95% confidence interval (Cl), 1.04-1.22], 1.05 (95% Cl, 0.98-1.13) or 1.06 (95% Cl, 0.99-1.14) controlling for O3, NO2 or SO2, respectively. Also the RR of cancer mortality for each increment of 30 days/year of PM10 in excess of 100 pg/m3 was 1.16 (95% Cl: 1.03-1.31).</p> <p>In the AHSMOG airport subcohort (n=3,239), the RR for fatal CHD with each 10 pg/m3 increase in PM2.5 was 2.00 (95 % Cl: 1.51, 2.64) in the two pollutant model with O3 in females. Corresponding RR’s for a 10 pg/m3 increases in PM10-2.5 and PM10 were 1.62 and 1.45, respectively, in all females. No significant associations were found in males.</p> <p>A positive association with fatal CHD was found with all three PM fractions in females, but not in males. The risk estimates were more significant after adjustment for gaseous pollutants, especially O3. The risk estimates were the highest for PM2.5. Also, increased risks of NMRD and cancer mortality were found with ambient levels of PM10 and gases (O3, or SO2).</p>

Name thesis:degree_name

Doctor of Public Health (DrPH)

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Epidemiology and Biostatistics

Year

2010

Author dc:creator

• Chen, Lie Hong

Contributors dc:contributor

• Synnove M. F. Knutsen
• W. Lawrence Beeson
• Samuel Soret

• Biostatistics
• Cardiovascular Diseases
• Epidemiology
• Coronary Disease -- epidemiology -- United States; Coronary Disease -- in old age; Cardiovascular Diseases -- mortality; Risk Factor; Air Pollutants -- adverse effects; Air Pollution -- California; Environmental Exposure.

Statement dc:rights

• This title appears here courtesy of the author, who has granted Loma Linda University a limited, non-exclusive right to make this publication available to the public. The author retains all other copyrights.

Language dc:language

English

Repository record dc:identifier

https://scholarsrepository.llu.edu/etd/1136

OAI identifier oai:identifier

oai:scholarsrepository.llu.edu:etd-2078