The Effect of Ethanol on Bone Histomorphology
The effect of ethanol on bone histomorphology was studied using an isocaloric liquid pair feeding system to administer equal amounts of essential vitamins and nutrients to control and ethanol animals. A bone remodeling sequence was induced in the lower right mandible by removal of the upper right molars. The bone remodeling unit, consisting mainly of the osteoclast and osteoblast, could then be studied microscopically to note any changes brought about by the administration of ethanol. Although the method of ethanol administration was successful, the induction of unintended bone remodeling via the removal of a solid diet made analysis of the results difficult. A method for inducing a localized remodeling sequence in an area other than the mandible would be preferable when repeating the experiment at a future date. Results were insignificant due to a need for more ethanol animals per day of sacrifice. A possible slowing or lag time was noted in the ethanol animals but cannot be considered significant since standard deviations were high and P values were high as well.
Anatomy, Alcohol, Ethyl; Bone Regeneration; Bone Resorption; Osteoclasts Osteoblasts
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