Selenium-induced Enhancement of Hematoporphyrin Derivative Phototoxicity in Murine Bladder Tumor Cells

<p>The phototoxicity of hematoporphyrin derivative (Hpd) to murine bladder tumor (MBT-2) cells was studied in vitro. It was observed that selenium in the form of sodium selenite enhanced Hpd-sensitized photodamage in MBT-2 cells under conditions where the selenite alone was non-toxic. Sodium selenite was found to enhance the fluorescence emission of Hpd and augment the Hpd-sensitized photooxidation of tryptophan. The data indicate that sodium selenite is able to disaggregate Hpd, thereby enhancing Hpd-sensitized phototoxicity.</p>

Name thesis:degree_name

Master of Arts (MA)

Level thesis:degree_level

Thesis

Discipline thesis:degree_discipline

Biology

Year

1986

Author dc:creator

• Tosk, Jeffrey M.

Contributors dc:contributor

• Benjamin H. S. Lau
• A. Graham Maxwell
• Elwood S. McCluskey
• Robert W. Teel

• Biology
• Microbiology
• Physiology
• Neoplasms -- therapy; Photochemotherapy; Cytotoxins; Selenium

Statement dc:rights

• This title appears here courtesy of the author, who has granted Loma Linda University a limited, non-exclusive right to make this publication available to the public. The author retains all other copyrights.

Language dc:language

English

Repository record dc:identifier

https://scholarsrepository.llu.edu/etd/744

OAI identifier oai:identifier

oai:scholarsrepository.llu.edu:etd-1637