Experimental Models of Brain Hemorrhage Using Clostridial Collagenase
Stroke is the third leading cause of death and is the leading cause of disability in the United States, and the most severe form is known as intracerebral hemorrhage, which is bleeding into the brain. The goal of this study is to establish novel animal models to buildup foundations for translational research of intracerebral hemorrhage. We, for the first time, established four animal models, including cerebellum hemorrhage, pontine hemorrhage, neonatal matrix hemorrhage and maternal postpartum hemorrhage. Those models are established according to intracerebral hemorrhage patient subpopulations, and characterized the neurobehavioral and morphological outcomes. These studies have established the requisite for future translational work to test neuroprotective drugs with the aim of improving the quality of life for these vulnerable patient populations.
Physiology, Cerebrovascular Disorders; Brain Edema; Disease Models - Animal; Cerebral Hemorrhage, Stroke, Intracerebral Hemorrhage, Translational Research, Animal Models--Hemorrhage
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