Stroke is the third leading cause of death and is the leading cause of disability in the United States, and the most severe form is known as intracerebral hemorrhage, which is bleeding into the brain. The goal of this study is to establish novel animal models to buildup foundations for translational research of intracerebral hemorrhage. We, for the first time, established four animal models, including cerebellum hemorrhage, pontine hemorrhage, neonatal matrix hemorrhage and maternal postpartum hemorrhage. Those models are established according to intracerebral hemorrhage patient subpopulations, and characterized the neurobehavioral and morphological outcomes. These studies have established the requisite for future translational work to test neuroprotective drugs with the aim of improving the quality of life for these vulnerable patient populations.
","abstract_html":"<p>Stroke is the third leading cause of death and is the leading cause of disability in the United States, and the most severe form is known as intracerebral hemorrhage, which is bleeding into the brain. The goal of this study is to establish novel animal models to buildup foundations for translational research of intracerebral hemorrhage. We, for the first time, established four animal models, including cerebellum hemorrhage, pontine hemorrhage, neonatal matrix hemorrhage and maternal postpartum hemorrhage. Those models are established according to intracerebral hemorrhage patient subpopulations, and characterized the neurobehavioral and morphological outcomes. These studies have established the requisite for future translational work to test neuroprotective drugs with the aim of improving the quality of life for these vulnerable patient populations.</p>","abstract_has_math":false,"creators":["Lekic, Tim"],"institution":null,"degree_name":"Doctor of Philosophy (PhD)","degree_level":"Thesis","degree_discipline":"Physiology","degree_department":null,"school":null,"contributors":["Zhang, John","Hartman, Richard","Obenaus, Andre","Ostrowski, Robert","Tang, jiping"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2010,"date_issued":"2010-09-01T07:00:00Z","date_published":"2010-09-01T07:00:00Z","updated_at":"2026-07-24T02:52:15Z","subjects":["Physiology","Cerebrovascular Disorders; Brain Edema; Disease Models - Animal; Cerebral Hemorrhage","Stroke","Intracerebral Hemorrhage","Translational Research","Animal Models--Hemorrhage"],"languages":["English"],"rights":["This title appears here courtesy of the author, who has granted Loma Linda University a limited, non-exclusive right to make this publication available to the public. The author retains all other copyrights."],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://scholarsrepository.llu.edu/etd/166","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Zhang, John","Hartman, Richard","Obenaus, Andre","Ostrowski, Robert","Tang, jiping"]},{"key":"dc:creator","label":"Author","values":["Lekic, Tim"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"thesis:degree_discipline","label":"Discipline","values":["Physiology"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Thesis"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Doctor of Philosophy (PhD)"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Physiology","Cerebrovascular Disorders; Brain Edema; Disease Models - Animal; Cerebral Hemorrhage","Stroke","Intracerebral Hemorrhage","Translational Research","Animal Models--Hemorrhage"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["English"]},{"key":"dc:rights","label":"Dc Rights","values":["This title appears here courtesy of the author, who has granted Loma Linda University a limited, non-exclusive right to make this publication available to the public. The author retains all other copyrights."]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://scholarsrepository.llu.edu/etd/166"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Stroke is the third leading cause of death and is the leading cause of disability in the United States, and the most severe form is known as intracerebral hemorrhage, which is bleeding into the brain. The goal of this study is to establish novel animal models to buildup foundations for translational research of intracerebral hemorrhage. We, for the first time, established four animal models, including cerebellum hemorrhage, pontine hemorrhage, neonatal matrix hemorrhage and maternal postpartum hemorrhage. Those models are established according to intracerebral hemorrhage patient subpopulations, and characterized the neurobehavioral and morphological outcomes. These studies have established the requisite for future translational work to test neuroprotective drugs with the aim of improving the quality of life for these vulnerable patient populations.
"]},{"key":"dc:title","label":"Title","values":["Experimental Models of Brain Hemorrhage Using Clostridial Collagenase"]}]}],"canonical_facts":{"dc:contributor":["Zhang, John","Hartman, Richard","Obenaus, Andre","Ostrowski, Robert","Tang, jiping"],"dc:creator":["Lekic, Tim"],"dc:description.abstract":["Stroke is the third leading cause of death and is the leading cause of disability in the United States, and the most severe form is known as intracerebral hemorrhage, which is bleeding into the brain. The goal of this study is to establish novel animal models to buildup foundations for translational research of intracerebral hemorrhage. We, for the first time, established four animal models, including cerebellum hemorrhage, pontine hemorrhage, neonatal matrix hemorrhage and maternal postpartum hemorrhage. Those models are established according to intracerebral hemorrhage patient subpopulations, and characterized the neurobehavioral and morphological outcomes. These studies have established the requisite for future translational work to test neuroprotective drugs with the aim of improving the quality of life for these vulnerable patient populations.
"],"dc:identifier":["https://scholarsrepository.llu.edu/etd/166"],"dc:language":["English"],"dc:rights":["This title appears here courtesy of the author, who has granted Loma Linda University a limited, non-exclusive right to make this publication available to the public. The author retains all other copyrights."],"dc:subject":["Physiology","Cerebrovascular Disorders; Brain Edema; Disease Models - Animal; Cerebral Hemorrhage","Stroke","Intracerebral Hemorrhage","Translational Research","Animal Models--Hemorrhage"],"dc:title":["Experimental Models of Brain Hemorrhage Using Clostridial Collagenase"],"thesis:degree_discipline":["Physiology"],"thesis:degree_level":["Thesis"],"thesis:degree_name":["Doctor of Philosophy (PhD)"]},"updated_at":"2026-07-24T02:52:15Z"}