Effect of a Single High-Fat Meal and Vitamins on the Circulatory Response to Local Heat in Koreans and Caucasians
type: CreativeWork
description: Blood flow mediated by the vascular endothelium plays an important role in removing heat from the skin. Asians who have thrifty genes have impaired endothelial function (EF) due to the westernized high fat (HF) dietary lifestyle. Hypertriglyceridemia (HTG) can produce free radicals which reduces the bioavailability of the endothelium derived relaxing factor, nitric oxide (NO). EF, as measured by the blood flow response (BFR) to heat, occlusion and the free radical concentration after a single HF meal has not been studied in Korean-Asians compared to Caucasians. The purpose of this study was to evaluate baseline and postprandial EF as related to oxidative stress from a single HF and low fat (LF) meal and the effects of vitamins on scavenging free radicals and improving EF in Korean-Asians compared to Caucasians. This was done by assessing skin BFR to vascular occlusion and local heat and analyzing malondialdehyde (MDA) levels after ingestion of a HF and LF meal before and after vitamin intake. Ten Caucasians and ten Koreans participated in the study (mean age 25.3 Â± 3.6 years). BFR to vascular occlusion and local heat and oxidative stress was assessed after a single HF and LF meal at 2 hours compared to baseline. After administration of vitamins (1000mg vitamin C, 800IU vitamin E, and 300mg Coenzyme Q-10) for 14 days, the same measurements were repeated. The results of this investigation showed that the skin BFR to vascular occlusion and local heat at baseline was significantly lower in Koreans than Caucasians. The skin BFR to vascular occlusion and local heat following a HF meal significantly decreased and free radicals significantly increased at 2 hours compared to baseline in Koreans (p<.001), but not in Caucasians. Also, the skin BFR to vascular occlusion (p=0.001) and local heat (p=0.003) was significantly lower and free radicals (p=0.004) were significantly higher at 2 hours after the HF meal in Koreans than Caucasians. When vitamins were given, the BFR to vas…
abstract: Blood flow mediated by the vascular endothelium plays an important role in removing heat from the skin. Asians who have thrifty genes have impaired endothelial function (EF) due to the westernized high fat (HF) dietary lifestyle. Hypertriglyceridemia (HTG) can produce free radicals which reduces the bioavailability of the endothelium derived relaxing factor, nitric oxide (NO). EF, as measured by the blood flow response (BFR) to heat, occlusion and the free radical concentration after a single HF meal has not been studied in Korean-Asians compared to Caucasians. The purpose of this study was to evaluate baseline and postprandial EF as related to oxidative stress from a single HF and low fat (LF) meal and the effects of vitamins on scavenging free radicals and improving EF in Korean-Asians compared to Caucasians. This was done by assessing skin BFR to vascular occlusion and local heat and analyzing malondialdehyde (MDA) levels after ingestion of a HF and LF meal before and after vitamin intake. Ten Caucasians and ten Koreans participated in the study (mean age 25.3 Â± 3.6 years). BFR to vascular occlusion and local heat and oxidative stress was assessed after a single HF and LF meal at 2 hours compared to baseline. After administration of vitamins (1000mg vitamin C, 800IU vitamin E, and 300mg Coenzyme Q-10) for 14 days, the same measurements were repeated. The results of this investigation showed that the skin BFR to vascular occlusion and local heat at baseline was significantly lower in Koreans than Caucasians. The skin BFR to vascular occlusion and local heat following a HF meal significantly decreased and free radicals significantly increased at 2 hours compared to baseline in Koreans (p<.001), but not in Caucasians. Also, the skin BFR to vascular occlusion (p=0.001) and local heat (p=0.003) was significantly lower and free radicals (p=0.004) were significantly higher at 2 hours after the HF meal in Koreans than Caucasians. When vitamins were given, the BFR to vas…
author: Yim, JongEun
language: English
keywords: Physical Therapy, Physical Therapy; Diet; Koreans; Caucasians, High-Fat Diets, Circulatory System, Koreans, Caucasians, Endothelial Function, Blood Flow Response, Cardiovascular Disease, Dietary Lifestyle, Local Heat, Vascular Occlusion
date published: 2012-03-01T08:00:00Z
date modified: 2026-07-24T02:52:15Z
provider: Loma Linda University
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: Loma Linda University