Labordiagnostische Referenzbereiche bei unterschiedlichen Schweinerassen sowie histopathologische und immunhistochemische Untersuchung von Gehirnen älterer Sauen und Eber auf transmissible spongiforme Enzephalopathie im Rahmen der TSE-Studie

The aim of the present study was to make a statement about selected blood ingredients for twelve pig breeds regarding the influence of the genotype. A possible race-dependence was proved for haematological parameters especially for erythrocytes, thrombocytes and leucocytes. Differences between the breeds were also found for electrolytes and the trace elements although a statement concerning breed-specifity was more difficult because some other environmental factors can have strong influence on these parameters as well. In part clear differences, which are caused by different physical characteristics and attributes of the animals such as muscle mass and susceptibility to stress, were established for substrates and enzymes. We were able to show that the pietrain pigs possess a remarkably higher concentration of some blood ingredients, in comparison with “German Landrace and Edelschwein“. To conclude, the results show, that there are marked differences in characteristics. We detected a varying influence of the genotype on the hematological and chemical blood parameters. The varying concentration of the blood parameters in the examined breeds seems to result from breed-specific metabolism and resistance to infections and environmental influence. The immune-histochemical search for accumulation of pathological prion protein with the antibody L42 in 48 brain tissue sections of both sows and boars was negativ. Nonetheless, it is possible to experimentally infect pigs with the infectious prion protein from cattle. This means that, in spite of the species-barrier, even though the infection was transmitted parenterally, pigs, along with many other animals, are susceptible to an infection with the bse-agent. There is a definite need for acquiring further knowledge on the exact onset of and events during infection and on the degree of contagiousness of transmissible spongiform encephalopathy not only in swine.

Level thesis:degree_level

thesis.doctoral

Grantor dc:publisher

Ludwig-Maximilians-Universität

Year

2004

Author dc:creator

• Kixmöller, Marion

Repository record source_url

https://edoc.ub.uni-muenchen.de/2198/

OAI identifier oai:identifier

oai:edoc.ub.uni-muenchen.de:2198