Klinische Studien über die Immobilisation von Mantelpavianen (Papio hamadryas) unter Verwendung der "Hellabrunner Mischung" und über den postnarkotischen Einfluss von Atipamezol und Yohimbin im Vergleich zu Etilefrin als Aufwachbeschleuniger

The objective of the present study was to examine the effectiveness of the anesthetic combination "Hellabrunne mixture" ("HM" = approximately 125mg xylazine/ml and 100mg ketamine/ml) on hamadryas baboons, as well as the influence of various drugs over the time it took the baboons to wake up (their "waking up phase") under practical conditions. In order to remobilize the baboons, comparative studies were conducted using: alpha2-specific antagonists atipamezole and yohimbine as well as the circulation stimulating drug etilefrine. The "HM" proved to be a very safe and effective anesthetic, even when given in doses that were too low or when overdosed. None of the examined animals had any life threatening incidents. All of the measured physiological parameters were normal and remained stabile during anesthesia. The three assayed accelerators used to remobilize the baboons (atipamezole, yohimbine, etilefrine) showed substantial differences in their effects. Atipamezole caused the baboons to regain consciousness significantly faster than the other drugs. However, some of the animals that were administered atipamezole had catalepsis cramps during their waking up phase. These side effects can be explained most likely, by the fact that atipamezole only antagonizes the xylazine component of the "HM" which causes a relative overdose of ketamine. Examining the effects of yohimbine administered i.m. (in contrast to the usual i.v. administration) yielded no substantial acceleration of remobilization. The same side effects were observed after administering atipamezole. Similar to atipamezole, etilefrine also shortened the waking up phase significantly, but to a lesser extent than atipamezole. In contrast to atipamezole and yohimbine, no side effects were observed after administering etilefrine. In summary, the i.m. administration of atipamezole and etilefrine proved to be suitable to shorten the waking up phase of hamadryas baboons after using "HM". In contrast, yohimbine cannot be recommended, as noticeable side effects were evident and no significant acceleration of remobilization was observed.

Level thesis:degree_level

thesis.doctoral

Grantor dc:publisher

Ludwig-Maximilians-Universität

Year

2004

Author dc:creator

• Hingerle, Antonia

Repository record source_url

https://edoc.ub.uni-muenchen.de/1919/

OAI identifier oai:identifier

oai:edoc.ub.uni-muenchen.de:1919