Zinkserumresponse beim Pferd nach oraler Verabreichung von unterschiedlichen Zinkverbindungen
Summary In the here presented study, the zinc serum response was investigated after the application of 4 different zinc compounds with varying dosages. To be able to consider species differences, dogs and cats were also supplemented with the same compounds and the zinc serum values measured. A total of 4 ponies, 12 dogs and 11 cats were alternately fed with zinc oxide, zinc sulfate, zinc lactate and B-Traxim using a single dose of 10 mg zinc/kg KM and the zinc serum levels measured over the next 24 hours. For the ponies, the effect of a single dose of 20 mg zinc/kg KM (except zinc lactate) was also measured. In the third approach, the ponies were supplemented 2,5 mg zinc/kg KM per day for a total of 14 days. The results were as follows: • The zinc serum level increased significantly after the application of zinc sulfate and B-traxim in relation to the dosage (Tab. 1). Zinc lactate also showed signs of a potential increase but due to the reduced tolerance was only tested in the lower dosages. In contrast, zinc oxide did not show a significant zinc serum response regardless of the applied amount. Tab. 1: Mean values of the maxima with standard deviation (SD) and minimum / maximum zinc serum values for the ponies (Mean values, not indicated with the same letter differ significantly) 10 mg Zn / kg KM 20 mg Zn / kg KM Compound Mean Maxima SD Range Mean Maxima SD Range Control 860  200b 660-1102 854  209b 649-1146 Zinc oxide 1100  340ab 776-1564 1136  463b 842-1785 Zinc sulfate 2080  800a 1030-2805 4134  1323a 2880-5888 B-Traxim 2120  670a 1397-2885 4895  1497a 3136-6206 Zinc lactate 1810  630ab 1171-2638 • No significant increase of the zinc serum levels could be found after the daily application of 2,5 mg zinc/kg KM over the 2 weeks. All levels were within the range of the ones presented in current literature. • For the dogs and cats, no significant zinc serum response could be determined after the supplementation of 10 mg zinc/kg KM, regardless of the zinc compound. For the cats, it could be speculated that the zinc serum response showed a certain tendency to higher serum levels after the application of zinc sulfate, B-traxim and zinc lactate. For these investigations, it can be concluded that zinc sulfate and B-traxim are available in the horse and are thus suited for the use in studies on zinc supplementation in regards to hoof quality. But one needs to consider, that from the results presented in this study, it can not be excluded that zinc oxide or zinc lactate are also available in the horse under certain circumstances.
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