oai:edoc.ub.uni-muenchen.de:1768
type: CreativeWork
name: Die Bedeutung einer Dilatation der Vena femoralis communis für die Pathophysiologie der chronischen Veneninsuffizienz und der Stellenwert einer Diameterbestimmung der Vena femoralis communis als diagnostisches und prognostisches Kriterium der CVI im Rahmen der degenerativen Venenerkrankungen
description: Background: Chronic Venous Disease (CVD) is one of the most frequent illnesses in the industrialised countries. Its prevalence within adult population exceeds in some European countries 50%. This accounts for 1.5 till 2.0 % of health care expenditures. Varicose veins (vv) and CVD decrease the quality of life of patients and their families. Venous wall degeneration is common primary cause of CVD. However, the pathophysiologic role of degenerative venodilation has not yet been finally established. In contrast to venous obstruction and venous reflux, venodilation has not been acknowledged by experts as a substrate of CVD. The aim of this study was to examine the role of dilation of Common Femoral Vein (CFV) as possible risk factor for CVD. Methods: In this cross-sectional study a total of 249 right legs (including 181 women and 68 men) were analysed. According to the CEAP classification study population was limited to primary aetiology (EP). DVT (PO) and other secondary and congenital causes of CVD (ECS) were excluded. Subjects with clinical stage 0, 1 or 2 (C0-2) were considered as non-diseased, otherwise (C3-6) as diseased. Right (n=249) and left (n=242) legs were analysed separately. Multiple logistic regression analysis was performed with the aid of SAS System. Results: The risk of CVD was around 10-fold higher in women with CFV diameter exceeding 14.0 mm as compared with those having diameter of 14.0 mm or less (adjusted for age, vv, and CFV-reflux). Based on Receiver-Operating-Characteristics curves, the ability to discriminate between diseased and non-diseased legs was higher for CFV dilation then for CFV-reflux. The curve of association between the CFV diameter and risk of CVD rose monotonically and revealed exposure-effect pattern. In women two threshold values were found for CFV diameter: at 14.0 and 17.5 mm; in men only one: at 17.5 mm. Final logistic model (women) included four covariates: age, vv, CFV-diameter and CFV-reflux duration. A probability of CVD …
abstract: Background: Chronic Venous Disease (CVD) is one of the most frequent illnesses in the industrialised countries. Its prevalence within adult population exceeds in some European countries 50%. This accounts for 1.5 till 2.0 % of health care expenditures. Varicose veins (vv) and CVD decrease the quality of life of patients and their families. Venous wall degeneration is common primary cause of CVD. However, the pathophysiologic role of degenerative venodilation has not yet been finally established. In contrast to venous obstruction and venous reflux, venodilation has not been acknowledged by experts as a substrate of CVD. The aim of this study was to examine the role of dilation of Common Femoral Vein (CFV) as possible risk factor for CVD. Methods: In this cross-sectional study a total of 249 right legs (including 181 women and 68 men) were analysed. According to the CEAP classification study population was limited to primary aetiology (EP). DVT (PO) and other secondary and congenital causes of CVD (ECS) were excluded. Subjects with clinical stage 0, 1 or 2 (C0-2) were considered as non-diseased, otherwise (C3-6) as diseased. Right (n=249) and left (n=242) legs were analysed separately. Multiple logistic regression analysis was performed with the aid of SAS System. Results: The risk of CVD was around 10-fold higher in women with CFV diameter exceeding 14.0 mm as compared with those having diameter of 14.0 mm or less (adjusted for age, vv, and CFV-reflux). Based on Receiver-Operating-Characteristics curves, the ability to discriminate between diseased and non-diseased legs was higher for CFV dilation then for CFV-reflux. The curve of association between the CFV diameter and risk of CVD rose monotonically and revealed exposure-effect pattern. In women two threshold values were found for CFV diameter: at 14.0 and 17.5 mm; in men only one: at 17.5 mm. Final logistic model (women) included four covariates: age, vv, CFV-diameter and CFV-reflux duration. A probability of CVD …
author: Dyszynski, Tomasz
date published: 2004-01-29
date modified: 2026-07-24T02:51:50Z
provider: Ludwig Maxmilians Universität München
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: Ludwig-Maximilians-Universität