Untersuchungen zur differenzialdiagnostischen Bedeutung des IgG-Index und Albuminquotienten bei neurologisch erkrankten Hunden
type: CreativeWork
description: Investigation of IgG index and albumin quotient for the differential diagnosis of dogs with neurological diseases In the present study the benefit of IgG index and albumin quotient for the differential diagnosis in dogs with neurological diseases was investigated. The question whether the determination of these two parameters is a convenient extension of the conventional cerebrospinal fluid (CSF) examination was explored. The IgG index served as an indicator for intrathecal IgG synthesis, the albumin quotient as an indicator for disturbances in the blood-brain barrier. The concentrations of albumin and IgG in CSF and serum of 122 dogs were determined with the help of nephelometry, followed by the calculation of the albumin quotient and IgG index. The conventional CSF examination included cell count, cell morphology, Pandy’s test, and protein content. All 122 dogs could be categorized into five different groups according to the clinical and pathological findings: inflammatory diseases (n = 33), tumors (n = 11), disc prolaps (n = 37), orthopedic diseases (n = 20), and idiopathic epilepsy (n = 21). In 10% of the examined dogs (12 of 122), pathological findings of the cerebrospinal fluid could only be exposed with the help of IgG index or albumin quotient, with the total protein level being normal. This result was equivalent to 14% of the dogs with normal total protein levels. Among these patients were dogs with white dog shaker disease, distemper, steroid responsive meningitis arteritis, and plexus carcinoma. On the other side, dogs with increased CSF total protein had a 97% chance of increased IgG index or albumin quotient. 67% of the dogs with inflammatory diseases showed an increase in IgG index and 70% an increase in albumin quotient. In 46% of these animals both parameters were elevated. Maximum changes were observed in dogs with central European tick-borne encephalitis. Dogs with white dog shaker disease were the only ones to exhibit an exclusive increase in the …
abstract: Investigation of IgG index and albumin quotient for the differential diagnosis of dogs with neurological diseases In the present study the benefit of IgG index and albumin quotient for the differential diagnosis in dogs with neurological diseases was investigated. The question whether the determination of these two parameters is a convenient extension of the conventional cerebrospinal fluid (CSF) examination was explored. The IgG index served as an indicator for intrathecal IgG synthesis, the albumin quotient as an indicator for disturbances in the blood-brain barrier. The concentrations of albumin and IgG in CSF and serum of 122 dogs were determined with the help of nephelometry, followed by the calculation of the albumin quotient and IgG index. The conventional CSF examination included cell count, cell morphology, Pandy’s test, and protein content. All 122 dogs could be categorized into five different groups according to the clinical and pathological findings: inflammatory diseases (n = 33), tumors (n = 11), disc prolaps (n = 37), orthopedic diseases (n = 20), and idiopathic epilepsy (n = 21). In 10% of the examined dogs (12 of 122), pathological findings of the cerebrospinal fluid could only be exposed with the help of IgG index or albumin quotient, with the total protein level being normal. This result was equivalent to 14% of the dogs with normal total protein levels. Among these patients were dogs with white dog shaker disease, distemper, steroid responsive meningitis arteritis, and plexus carcinoma. On the other side, dogs with increased CSF total protein had a 97% chance of increased IgG index or albumin quotient. 67% of the dogs with inflammatory diseases showed an increase in IgG index and 70% an increase in albumin quotient. In 46% of these animals both parameters were elevated. Maximum changes were observed in dogs with central European tick-borne encephalitis. Dogs with white dog shaker disease were the only ones to exhibit an exclusive increase in the …
author: Schindler, Thomas
date published: 2003-07-18
date modified: 2026-07-24T02:51:47Z
provider: Ludwig Maxmilians Universität München
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: Ludwig-Maximilians-Universität