Möglichkeiten der Frühdiagnostik der Osteomyelitis durch Magnetresonanz-Tomographie - Experimentelle Untersuchungen am Kaninchen

Possibilities of early diagnosis of osteomyelitis by magnetic resonance tomography - experimental studies in rabbits Correlation of MR-images and macroscopic sections demonstrates, that anatomical structures of rabbits can be excellently visualized by MRT. Clinically used MR-systems are able to provide satisfactory resolution. Following experimentally induced osteomyelitis infected bone marrow can be detected by decreased signal on native T1-weighted and increased signal on T2-weighted images. After administration of gadolinium-DTPA marked enhancement can be observed. Detection of soft-tissue infection is superior on T2-wheigted scans showing high signal intensity. After administration of gadolinium DTPA rim enhacement provides good differentiation of abscessmembrane. Especially in earlier stages of disease (3 to 5, 8 to 12 and 12 to 19 days post infection) the sensitivity of native MRT (80%, 100%, about 67%) is superior compared to other diagnostic modalities, e.g. radiography (about 29%, about 46%, 50%), CT-scan (about 29%, about 13%, about 17%) and scintigraphy (60%, about 78%, 100%). Gadolinium-DTPA increases sensitivity (100%, 100%, 100%). At the end of the observation period bone scintigraphy provides the same sensitivity. MRT, however, is superior in detecting involvement of bone marrow and soft-tissue infection. Compared to scintigraphy and MRT radiography and CT-scan shows lower sensitivity during the whole observation period. Regional differences in detecting osteomyelitis can be recognized unsing MRT, less using other modalities. In early stages of the disease most infectious lesions are detected in the proximal femur. Explanation can be a different involvement of the femur, but also a different diagnostic potential of MRT concerning different anatomical regions. All in all MRT is an excellent tool in the diagnosis of osteomyelitis and is superior to other imaging modalities. Application of contrast material provides further improvement in sensitivity. In the clinical use fat suppression and STIR-sequence have provided further improvement. The role of MRT as a diagnostic instrument in osteomyelitis is established in clinical medicine and seems promising in veterinary medicine.

Level thesis:degree_level

thesis.doctoral

Grantor dc:publisher

Ludwig-Maximilians-Universität

Year

2003

Author dc:creator

• Binder, Hans-Artur

Repository record source_url

https://edoc.ub.uni-muenchen.de/1536/

OAI identifier oai:identifier

oai:edoc.ub.uni-muenchen.de:1536