Abstract
dc:description.abstractThe simple metazoan Hydra does posses two genes for caspases: Caspase 3A and caspase 3B. We generated antibodies against these caspases. By immunofluorescence staining and cell fractionation we demonstrated that both caspases are localized in mitochondria in vivo.Caspase 3A is a constitutively active enzyme independent of PCD. After induction of apoptosis caspase 3B translocates from the mitochondria to the cytoplasm and is activated. Activity of 3B is DEVD-specific.
Degree
thesis:*- Level thesis:degree_level
- thesis.doctoral
- Grantor dc:publisher
- Ludwig-Maximilians-Universität
- Year
- 2003
Author and committee
dc:creator, dc:contributor.*- Author dc:creator
-
- Schmidt, Nikola
Identifiers
dc:identifier.*- Repository record source_url
- https://edoc.ub.uni-muenchen.de/1241/
- OAI identifier oai:identifier
- oai:edoc.ub.uni-muenchen.de:1241