Effects of Tea on Peripheral and Cerebral Micro- and Macrovascular Function in Humans
type: CreativeWork
description: Cardiovascular disease (CVD) is the leading cause of global mortality, with the incidence of cardiovascular related pathologies remaining a public health burden. CVD encompasses pathologies of the vascular tree and heart, including, for example, peripheral artery disease, coronary heart disease and ischaemic stroke. Atherosclerosis is the primary pathological process leading to CVD and is characterised by a multifactorial pathophysiology that first manifests in the vascular endothelium. Termed endothelial dysfunction, this early marker of atherosclerosis has become a focus of interest for identifying individuals at risk of a profound cardiovascular insult, particularly arising from lifestyle choices such as physical inactivity and calorie-rich diets. Dietary interventions have received increasing attention in recent years as inexpensive strategies to potentially combat the ever-increasing global burden of CVD. A high dietary flavonoid intake is associated with a reduction in CVD risk and several studies have revealed a strong, inverse relation between the regular intake of tea, a major source of dietary flavonoids, and CVD risk. Tea has demonstrated improved conduit artery endothelial function and glucose handling in both healthy individuals and in those with overt CVD. However, the effects of tea on the microvasculature and cerebrovasculature are not yet understood, particularly in relation to lifestyle factors. The primary aim of this thesis was to explore the impact of tea ingestion on peripheral and cerebral micro- and macrovascular function in humans. In an initial methodological study, the day-to-day reproducibility of thermally stimulated cutaneous microvascular function was assessed. Fifteen, healthy males (28 ± 5 yrs, BMI 25 ± 2 kg/m2) attended two experimental trials 2-7 days apart. During each trial, baseline and maximal thermally stimulated forearm skin responses were examined simultaneously at four sites on the dominant forearm using laser Doppler flowm…
abstract: Cardiovascular disease (CVD) is the leading cause of global mortality, with the incidence of cardiovascular related pathologies remaining a public health burden. CVD encompasses pathologies of the vascular tree and heart, including, for example, peripheral artery disease, coronary heart disease and ischaemic stroke. Atherosclerosis is the primary pathological process leading to CVD and is characterised by a multifactorial pathophysiology that first manifests in the vascular endothelium. Termed endothelial dysfunction, this early marker of atherosclerosis has become a focus of interest for identifying individuals at risk of a profound cardiovascular insult, particularly arising from lifestyle choices such as physical inactivity and calorie-rich diets. Dietary interventions have received increasing attention in recent years as inexpensive strategies to potentially combat the ever-increasing global burden of CVD. A high dietary flavonoid intake is associated with a reduction in CVD risk and several studies have revealed a strong, inverse relation between the regular intake of tea, a major source of dietary flavonoids, and CVD risk. Tea has demonstrated improved conduit artery endothelial function and glucose handling in both healthy individuals and in those with overt CVD. However, the effects of tea on the microvasculature and cerebrovasculature are not yet understood, particularly in relation to lifestyle factors. The primary aim of this thesis was to explore the impact of tea ingestion on peripheral and cerebral micro- and macrovascular function in humans. In an initial methodological study, the day-to-day reproducibility of thermally stimulated cutaneous microvascular function was assessed. Fifteen, healthy males (28 ± 5 yrs, BMI 25 ± 2 kg/m2) attended two experimental trials 2-7 days apart. During each trial, baseline and maximal thermally stimulated forearm skin responses were examined simultaneously at four sites on the dominant forearm using laser Doppler flowm…
author: Roberts, KA
keywords: TX341 Nutrition. Foods and food supply, RC1200 Sports Medicine
date published: 2018-02
date modified: 2026-07-24T06:30:22Z
provider: Liverpool Jon Moores University
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: Liverpool John Moores University

PropertyValue
property ID: DOI
value: 10.24377/LJMU.t.00007953