CHILDREN’S HIPS: INNOVATION IN THE DIAGNOSIS, MONITORING AND TREATMENT OF CHILDREN’S HIP DISEASES
type: CreativeWork
description: Perthes’ disease is an idiopathic osteonecrosis of a developmental hip that is most frequent in Northern Europe. Currently, the absence of a common set of standardized outcomes makes comparisons between studies of different interventions challenging. The overarching aim of this thesis was to understand and enhance the important clinically relevant outcomes that should be measured in Perthes’ disease. A protocol was devised to define a set of core outcomes (COS) (Study 1), which involved a systematic review of the literature, patient and associated family interviews and a Delphi survey. In Study 2, 18 parents were interviewed and perspectives of 12 children affected by Perthes’ disease (mean 7.1 years, SD±4.1 years) were explored using a survey tool. Thematic analysis of the parents interviews (main themes n=4) identified a marked effect of the disease on many facets of the child’s life, particularly pain and the impact on sleep, play and school attendance. Study 3 followed the guidelines of the COMET-Initiative (Core Outcome Measures in Effectiveness Trials) to define a COS for Perthes’ disease. The outcomes from the systematic review, together with the domains collected in Study 2, formed the basis of a Delphi survey (2 rounds), where 18 patients with Perthes’ disease, 46 parents and 36 orthopaedic surgeons rated each outcome for importance. A final consensus meeting among representatives of surgeons, patients and parents voted 14 outcomes to be included in the final Core Outcomes Set. Following the systematic review of previous studies (n=112), 33 outcomes were identified. After round 1 of the Delphi survey, participants suggested additional 5 outcomes, therefore a total of 38 outcomes were scored in round 2 of the Delphi. Among these, 16 outcomes (divided in 6 main categories: adverse events; life impact; resource use; pathophysiological manifestations; death; technical considerations) were scored over the 70% threshold for importance. After feedback from final c…
abstract: Perthes’ disease is an idiopathic osteonecrosis of a developmental hip that is most frequent in Northern Europe. Currently, the absence of a common set of standardized outcomes makes comparisons between studies of different interventions challenging. The overarching aim of this thesis was to understand and enhance the important clinically relevant outcomes that should be measured in Perthes’ disease. A protocol was devised to define a set of core outcomes (COS) (Study 1), which involved a systematic review of the literature, patient and associated family interviews and a Delphi survey. In Study 2, 18 parents were interviewed and perspectives of 12 children affected by Perthes’ disease (mean 7.1 years, SD±4.1 years) were explored using a survey tool. Thematic analysis of the parents interviews (main themes n=4) identified a marked effect of the disease on many facets of the child’s life, particularly pain and the impact on sleep, play and school attendance. Study 3 followed the guidelines of the COMET-Initiative (Core Outcome Measures in Effectiveness Trials) to define a COS for Perthes’ disease. The outcomes from the systematic review, together with the domains collected in Study 2, formed the basis of a Delphi survey (2 rounds), where 18 patients with Perthes’ disease, 46 parents and 36 orthopaedic surgeons rated each outcome for importance. A final consensus meeting among representatives of surgeons, patients and parents voted 14 outcomes to be included in the final Core Outcomes Set. Following the systematic review of previous studies (n=112), 33 outcomes were identified. After round 1 of the Delphi survey, participants suggested additional 5 outcomes, therefore a total of 38 outcomes were scored in round 2 of the Delphi. Among these, 16 outcomes (divided in 6 main categories: adverse events; life impact; resource use; pathophysiological manifestations; death; technical considerations) were scored over the 70% threshold for importance. After feedback from final c…
author: Leo, DG
keywords: RC1200 Sports Medicine, RJ Pediatrics, RJ101 Child Health. Child health services
date published: 2020-01
date modified: 2026-07-24T06:30:31Z
provider: Liverpool Jon Moores University
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: Liverpool John Moores University

PropertyValue
property ID: DOI
value: 10.24377/LJMU.t.00012099