The pharmacokinetics of sodium monofluoroacetate (1080) in rabbits

Sodium monofluoroacetate (1080) is a pesticide widely used in New Zealand to control rabbits and possums. Very little is known about the in vivo behaviour of 1080 in target and non target species. This experiment was carried out to investigate the persistence and tissue distribution of 1080 in rabbits and assess the risks associated with secondary poisoning. In this experiment New Zealand Large White rabbits were orally administered 0.1 mg 1080/kg W, a sublethal dose. This study demonstrated that 1080 is rapidly absorbed. The maximum concentration (0.106 µg/ml) of 1080 occurred in plasma 0.6 hours post dosing. The half life (t₁/₂) in plasma was 0.98 hours. The tissue distribution and elimination of 1080 was also rapid. No 1080 could be detected in tissue after 9 hours post dosing. This experiment clearly showed that 1080 does not persist for extended periods in the body. It is concluded that the hazard from consumption of a sublethally poisoned rabbit would be minimal to humans and other vulnerable non target species such as the dog.

Grantor dc:publisher

Lincoln University

Year dc:date

1991

Author dc:creator

• Dickson, Colin

• sodium monofluoroacetate
• 1080
• pharmacokinetics
• persistence
• rabbits
• hazard
• risk
• secondary poisoning
• ANZSRC::0601 Biochemistry and Cell Biology
• ANZSRC::060601 Animal Physiology - Biophysics

Statement dc:rights

• Digital thesis can be viewed by current staff and students of Lincoln University only. If you are the author of this item, please contact us if you wish to discuss making the full text publicly available.

Licence

• https://researcharchive.lincoln.ac.nz/pages/rights

Language dc:language

en

Identifier

Q112851166

OAI identifier oai:identifier

oai:researcharchive.lincoln.ac.nz:10182/3752