Role of the dorsomedial and ventrolateral medulla in the regulation of pain sensitivity in the endotoxemic organism

This study compared the physiological and morphological effects of vagus nerve transection to the chemical destruction of its central projections. Subdiaphragmatic vagotomy disturbed nociception and body temperature regulation during endotoxemia. Micro-injections of glutamate or vanilloid receptor agonists in toxic concentrations into the nucleus tractus solitarii (NTS) and the caudal ventrolateral medulla (CVLM) lead to the similar effect. Both types of intervention – vagotomy, and central microinjections – were followed by structural alterations in NTS and CVLM, which was visualized by the electron microscopy. The results suggest involvement of NTS and CVLM neurons in the regulation of nociceptive threshold during the acute phase reaction to endotoxins.

Grantor dc:publisher

Institute of Physiology of the National Academy of Sciences of Belarus

Year dc:date

2000

Author dc:creator

• Koulchitsky, Stanislav

Contributors dc:contributor

• Gourine, Valery
• Kulchitsky, Vladimir

• vagus nerve
• nociception
• thermoregulation
• electron microscopy
• brainstem
• Life sciences
• Anatomy (cytology, histology, embryology...) & physiology
• Sciences du vivant
• Anatomie (cytologie, histologie, embryologie...) & physiologie

Statement dc:rights

• restricted access
• info:eu-repo/semantics/restrictedAccess

Licence

• http://purl.org/coar/access_right/c_16ec

Language dc:language

ru

Identifier

info:hdl:2268/213384

OAI identifier oai:identifier

oai:orbi.ulg.ac.be:2268/213384