Differential neurogenesis in the adult rat dentate gyrus

Adult neurogenesis is a fundamental feature of mammalian nervous systems. Curiously, neurogenesis in the dentate gyrus is typically regarded as homogenous. This thesis challenges that view, and reports the discovery and characterization of a novel region of the dentate gyrus that consistently lacks basal neurogenesis. We demonstrate that this area, referred to as the neurogenically quiescent zone, represents approximately 1.5% of the total volume of the dentate gyrus, and that its location is invariant among animals. This region contains several critical cell types and molecular factors that are known to be critical to the neurogenic niche, including stem cells. We also present data that attempt to conceptualize the existence of this region in the context of early agerelated declines in neurogenesis. Finally, we demonstrate that, under some behavioural conditions, neurogenesis can be induced in this region, suggesting that, under basal conditions, it may simply lack the presence of pro-neurogenic factors.

Grantor dc:publisher

Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2008

Year dc:date.issued

2008

Authors dc:creator

• Melvin, Neal
• University of Lethbridge. Faculty of Arts and Science

Advisor dc:contributor.supervisor

• Sutherland, Robert J.

• Dissertations, Academic
• Developmental neurobiology
• Dentate gyrus
• Brain -- Research
• Rats as laboratory animals
• Hippocampus (Brain)

Language dc:language.iso

en_US

Identifier

hdl:10133/727

OAI record oai:identifier

https://opus.uleth.ca/server/oai/request?verb=GetRecord&metadataPrefix=dim&identifier=oai%3Aopus.uleth.ca%3A10133%2F727