{"id":{"repo_id":"lethbridge","oai_identifier":"oai:opus.uleth.ca:10133/6670"},"canonical_url":"https://search.dev.ndltd.org/etd/lethbridge/oai:opus.uleth.ca:10133/6670","repository":{"repo_id":"lethbridge","name":"University of Lethbridge","base_url":"https://opus.uleth.ca/server/oai/request"},"display":{"title":"The impacts of a cannabis extract on brain pathology and memory impairments associated with Alzheimer's disease in an APP-NL-G-F transgenic mouse model","abstract":"Alzheimer’s Disease (AD) is a devastating neurodegenerative disorder that is categorized by progressive memory loss and cognitive deterioration. Amyloid-beta (Aꞵ) proteins accumulate within AD brains and trigger harmful chronic inflammation. By targeting both Aꞵ and inflammation, disease progression may be delayed. Cannabis is a plant containing THC and CBD. Previous work in our lab has shown that these compounds are ineffective at reducing AD pathology independently; however, research suggests they are more effective when combined. This project utilizes a THC/CBD combination extract to evaluate AD pathology in APP mice by assessing performance on memory-based behavioural tasks and by using protein markers to determine disease progression and severity. There were no treatment-related effects of the extract found via behavioural testing. However, the extract did decrease PFC 4G8-stained Aꞵ plaques. There were no other significant effects on Aꞵ, inflammation, or HPC cell volume found. Sex differences were found on various behavioural tasks.","abstract_html":"Alzheimer’s Disease (AD) is a devastating neurodegenerative disorder that is categorized by progressive memory loss and cognitive deterioration. Amyloid-beta (Aꞵ) proteins accumulate within AD brains and trigger harmful chronic inflammation. By targeting both Aꞵ and inflammation, disease progression may be delayed. Cannabis is a plant containing THC and CBD. Previous work in our lab has shown that these compounds are ineffective at reducing AD pathology independently; however, research suggests they are more effective when combined. This project utilizes a THC/CBD combination extract to evaluate AD pathology in APP mice by assessing performance on memory-based behavioural tasks and by using protein markers to determine disease progression and severity. There were no treatment-related effects of the extract found via behavioural testing. However, the extract did decrease PFC 4G8-stained Aꞵ plaques. There were no other significant effects on Aꞵ, inflammation, or HPC cell volume found. Sex differences were found on various behavioural tasks.","abstract_has_math":false,"creators":["Robinson, Danika Andrea","University of Lethbridge. Faculty of Arts and Science"],"institution":null,"degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2023,"date_issued":"2023","date_published":"2023","updated_at":"2026-07-27T20:02:38Z","subjects":["Alzheimer's disease","cannabis extract","brain pathology","memory impairments","amyloid-beta proteins","chronic inflammation","THC","CBD"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["hdl:10133/6670"],"render_values":[{"text":"hdl:10133/6670","href":null,"code":true}]}]},"links":{"outbound_url":null,"outbound_label":null,"outbound_source":null},"metadata_groups":[{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.issued","label":"Date","values":["2023"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Alzheimer's disease","cannabis extract","brain pathology","memory impairments","amyloid-beta proteins","chronic inflammation","THC","CBD"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["hdl:10133/6670"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.other","label":"Dc Description Other","values":["Alzheimer’s Disease (AD) is a devastating neurodegenerative disorder that is categorized by progressive memory loss and cognitive deterioration. Amyloid-beta (Aꞵ) proteins accumulate within AD brains and trigger harmful chronic inflammation. By targeting both Aꞵ and inflammation, disease progression may be delayed. Cannabis is a plant containing THC and CBD. Previous work in our lab has shown that these compounds are ineffective at reducing AD pathology independently; however, research suggests they are more effective when combined. This project utilizes a THC/CBD combination extract to evaluate AD pathology in APP mice by assessing performance on memory-based behavioural tasks and by using protein markers to determine disease progression and severity. There were no treatment-related effects of the extract found via behavioural testing. However, the extract did decrease PFC 4G8-stained Aꞵ plaques. There were no other significant effects on Aꞵ, inflammation, or HPC cell volume found. Sex differences were found on various behavioural tasks."]},{"key":"dc:title","label":"Title","values":["The impacts of a cannabis extract on brain pathology and memory impairments associated with Alzheimer's disease in an APP-NL-G-F transgenic mouse model"]}]}],"canonical_facts":{"dc:date.issued":["2023"],"dc:description.other":["Alzheimer’s Disease (AD) is a devastating neurodegenerative disorder that is categorized by progressive memory loss and cognitive deterioration. Amyloid-beta (Aꞵ) proteins accumulate within AD brains and trigger harmful chronic inflammation. By targeting both Aꞵ and inflammation, disease progression may be delayed. Cannabis is a plant containing THC and CBD. Previous work in our lab has shown that these compounds are ineffective at reducing AD pathology independently; however, research suggests they are more effective when combined. This project utilizes a THC/CBD combination extract to evaluate AD pathology in APP mice by assessing performance on memory-based behavioural tasks and by using protein markers to determine disease progression and severity. There were no treatment-related effects of the extract found via behavioural testing. However, the extract did decrease PFC 4G8-stained Aꞵ plaques. There were no other significant effects on Aꞵ, inflammation, or HPC cell volume found. Sex differences were found on various behavioural tasks."],"dc:identifier":["hdl:10133/6670"],"dc:subject":["Alzheimer's disease","cannabis extract","brain pathology","memory impairments","amyloid-beta proteins","chronic inflammation","THC","CBD"],"dc:title":["The impacts of a cannabis extract on brain pathology and memory impairments associated with Alzheimer's disease in an APP-NL-G-F transgenic mouse model"],"dc:type":["Thesis"]},"updated_at":"2026-07-27T20:02:38Z"}