{"id":{"repo_id":"lethbridge","oai_identifier":"oai:opus.uleth.ca:10133/5108"},"canonical_url":"https://search.dev.ndltd.org/etd/lethbridge/oai:opus.uleth.ca:10133/5108","repository":{"repo_id":"lethbridge","name":"University of Lethbridge","base_url":"https://opus.uleth.ca/server/oai/request"},"display":{"title":"Low acetylcholine during early sleep is crucial for motor memory consolidation","abstract":"I investigated a potential relationship between motor memory and acetylcholine activity during early sleep characterized by slow-wave electroencephalographic activity and reduced cholinergic tone. I tested the hypothesis that altering acetylcholine levels during early sleep would disrupt motor memory consolidation. I trained 93 wild-type and 17 transgenic adult mice on motor tasks either rotarod or skilled-forelimb reach. Immediately after training, I either increased or decreased acetylcholine levels in the subsequent post-learning early sleep. Upon retesting performance on motor tasks, I discovered that increasing acetylcholine levels impaired motor memory consolidation while decreasing acetylcholine levels did not have an effect. I also found a larger involvement of muscarinic acetylcholine receptors compared to nicotinic ones for motor memory consolidation. With filming and electrophysiology, I determined that increasing acetylcholine altered sleep structure and reduced slow-wave activity in early sleep. These results suggest that motor memories are consolidated during slow-wave sleep when cholinergic levels are low.","abstract_html":"I investigated a potential relationship between motor memory and acetylcholine activity during early sleep characterized by slow-wave electroencephalographic activity and reduced cholinergic tone. I tested the hypothesis that altering acetylcholine levels during early sleep would disrupt motor memory consolidation. I trained 93 wild-type and 17 transgenic adult mice on motor tasks either rotarod or skilled-forelimb reach. Immediately after training, I either increased or decreased acetylcholine levels in the subsequent post-learning early sleep. Upon retesting performance on motor tasks, I discovered that increasing acetylcholine levels impaired motor memory consolidation while decreasing acetylcholine levels did not have an effect. I also found a larger involvement of muscarinic acetylcholine receptors compared to nicotinic ones for motor memory consolidation. With filming and electrophysiology, I determined that increasing acetylcholine altered sleep structure and reduced slow-wave activity in early sleep. These results suggest that motor memories are consolidated during slow-wave sleep when cholinergic levels are low.","abstract_has_math":false,"creators":["Qandeel","University of Lethbridge. Faculty of Arts and Science"],"institution":null,"degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2018,"date_issued":"2018","date_published":"2018","updated_at":"2026-07-27T20:02:20Z","subjects":["motor memory consolidation","sleep","acetylcholine neuromodulation","skilled forelimb reach task","rotarod task","electrophysiology","Acetylcholine","Memory consolidation","Slow wave sleep"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["hdl:10133/5108"],"render_values":[{"text":"hdl:10133/5108","href":null,"code":true}]}]},"links":{"outbound_url":null,"outbound_label":null,"outbound_source":null},"metadata_groups":[{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.issued","label":"Date","values":["2018"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["motor memory consolidation","sleep","acetylcholine neuromodulation","skilled forelimb reach task","rotarod task","electrophysiology","Acetylcholine","Memory consolidation","Slow wave sleep"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["hdl:10133/5108"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.other","label":"Dc Description Other","values":["I investigated a potential relationship between motor memory and acetylcholine activity during early sleep characterized by slow-wave electroencephalographic activity and reduced cholinergic tone. I tested the hypothesis that altering acetylcholine levels during early sleep would disrupt motor memory consolidation. I trained 93 wild-type and 17 transgenic adult mice on motor tasks either rotarod or skilled-forelimb reach. Immediately after training, I either increased or decreased acetylcholine levels in the subsequent post-learning early sleep. Upon retesting performance on motor tasks, I discovered that increasing acetylcholine levels impaired motor memory consolidation while decreasing acetylcholine levels did not have an effect. I also found a larger involvement of muscarinic acetylcholine receptors compared to nicotinic ones for motor memory consolidation. With filming and electrophysiology, I determined that increasing acetylcholine altered sleep structure and reduced slow-wave activity in early sleep. These results suggest that motor memories are consolidated during slow-wave sleep when cholinergic levels are low."]},{"key":"dc:title","label":"Title","values":["Low acetylcholine during early sleep is crucial for motor memory consolidation"]}]}],"canonical_facts":{"dc:date.issued":["2018"],"dc:description.other":["I investigated a potential relationship between motor memory and acetylcholine activity during early sleep characterized by slow-wave electroencephalographic activity and reduced cholinergic tone. I tested the hypothesis that altering acetylcholine levels during early sleep would disrupt motor memory consolidation. I trained 93 wild-type and 17 transgenic adult mice on motor tasks either rotarod or skilled-forelimb reach. Immediately after training, I either increased or decreased acetylcholine levels in the subsequent post-learning early sleep. Upon retesting performance on motor tasks, I discovered that increasing acetylcholine levels impaired motor memory consolidation while decreasing acetylcholine levels did not have an effect. I also found a larger involvement of muscarinic acetylcholine receptors compared to nicotinic ones for motor memory consolidation. With filming and electrophysiology, I determined that increasing acetylcholine altered sleep structure and reduced slow-wave activity in early sleep. These results suggest that motor memories are consolidated during slow-wave sleep when cholinergic levels are low."],"dc:identifier":["hdl:10133/5108"],"dc:subject":["motor memory consolidation","sleep","acetylcholine neuromodulation","skilled forelimb reach task","rotarod task","electrophysiology","Acetylcholine","Memory consolidation","Slow wave sleep"],"dc:title":["Low acetylcholine during early sleep is crucial for motor memory consolidation"],"dc:type":["Thesis"]},"updated_at":"2026-07-27T20:02:20Z"}