{"id":{"repo_id":"lethbridge","oai_identifier":"oai:opus.uleth.ca:10133/4790"},"canonical_url":"https://search.dev.ndltd.org/etd/lethbridge/oai:opus.uleth.ca:10133/4790","repository":{"repo_id":"lethbridge","name":"University of Lethbridge","base_url":"https://opus.uleth.ca/server/oai/request"},"display":{"title":"The effect of nucleus reuniens inactivation on neocortical K-complex and hippocampal sharp wave-ripple correlations","abstract":"Cortico-hippocampal communication is critical for cognitive processes including behavioural flexibility, and memory formation, consolidation, and retrieval. Nucleus reuniens of the thalamus has been implicated in memory consolidation. Consolidation involves the reactivation of hippocampal ensembles with neocortical memory traces to convert episodic memories to semantic knowledge and is believed to rely on coordinated interactions between sharp wave-ripples (SPWRs) and K-complexes (KCs). The aim of my study was to investigate whether inactivation of reuniens affects SPWR and KC coordination. I found that dialysis of lidocaine into reuniens did not affect the coordination of KCs and SPWRs. While previous studies have demonstrated effective local neural inactivation using lidocaine dialysis, I did not observe any effects that could be used to positively verify a drug effect. The data thus tentatively provide evidence that reuniens does not coordinate KSs and SPWRs. Future studies will be needed using methods for which inactivation can be positively identified.","abstract_html":"Cortico-hippocampal communication is critical for cognitive processes including behavioural flexibility, and memory formation, consolidation, and retrieval. Nucleus reuniens of the thalamus has been implicated in memory consolidation. Consolidation involves the reactivation of hippocampal ensembles with neocortical memory traces to convert episodic memories to semantic knowledge and is believed to rely on coordinated interactions between sharp wave-ripples (SPWRs) and K-complexes (KCs). The aim of my study was to investigate whether inactivation of reuniens affects SPWR and KC coordination. I found that dialysis of lidocaine into reuniens did not affect the coordination of KCs and SPWRs. While previous studies have demonstrated effective local neural inactivation using lidocaine dialysis, I did not observe any effects that could be used to positively verify a drug effect. The data thus tentatively provide evidence that reuniens does not coordinate KSs and SPWRs. Future studies will be needed using methods for which inactivation can be positively identified.","abstract_has_math":false,"creators":["Kesler, Mitchell T.","University of Lethbridge. Faculty of Arts and Science"],"institution":"Lethbridge, Alta : University of Lethbridge, Dept. of Neuroscience","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":["McNaughton, Bruce L."],"committee_chairs":[],"committee_members":[],"year":2016,"date_issued":"2016","date_published":"2016","updated_at":"2026-08-21T16:45:58Z","subjects":["KCs","lidocaine dialysis","medioventral nucleus","memory consolidation","mPFC","SPWRs"],"languages":["en_US"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["hdl:10133/4790"],"render_values":[{"text":"hdl:10133/4790","href":null,"code":true}]}]},"links":{"outbound_url":"https://hdl.handle.net/10133/4790","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"source_record":{"url":"https://opus.uleth.ca/server/oai/request?verb=GetRecord&metadataPrefix=dim&identifier=oai%3Aopus.uleth.ca%3A10133%2F4790","prefix":"dim"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.supervisor","label":"Supervisor","values":["McNaughton, Bruce L."]},{"key":"dc:creator","label":"Author","values":["Kesler, Mitchell T.","University of Lethbridge. Faculty of Arts and Science"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2017-03-06T18:04:00Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2017-03-06T18:04:00Z"]},{"key":"dc:date.issued","label":"Date","values":["2016"]},{"key":"dc:publisher","label":"Institution","values":["Lethbridge, Alta : University of Lethbridge, Dept. of Neuroscience"]},{"key":"dc:publisher.department","label":"Dc Publisher Department","values":["Department of Neuroscience"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["KCs","lidocaine dialysis","medioventral nucleus","memory consolidation","mPFC","SPWRs"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en_US"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["hdl:10133/4790"]},{"key":"dc:identifier.uri","label":"Identifier URI","values":["https://hdl.handle.net/10133/4790"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Cortico-hippocampal communication is critical for cognitive processes including behavioural flexibility, and memory formation, consolidation, and retrieval. Nucleus reuniens of the thalamus has been implicated in memory consolidation. Consolidation involves the reactivation of hippocampal ensembles with neocortical memory traces to convert episodic memories to semantic knowledge and is believed to rely on coordinated interactions between sharp wave-ripples (SPWRs) and K-complexes (KCs). The aim of my study was to investigate whether inactivation of reuniens affects SPWR and KC coordination. I found that dialysis of lidocaine into reuniens did not affect the coordination of KCs and SPWRs. While previous studies have demonstrated effective local neural inactivation using lidocaine dialysis, I did not observe any effects that could be used to positively verify a drug effect. The data thus tentatively provide evidence that reuniens does not coordinate KSs and SPWRs. Future studies will be needed using methods for which inactivation can be positively identified."]},{"key":"dc:description.other","label":"Dc Description Other","values":["Cortico-hippocampal communication is critical for cognitive processes including behavioural flexibility, and memory formation, consolidation, and retrieval. Nucleus reuniens of the thalamus has been implicated in memory consolidation. Consolidation involves the reactivation of hippocampal ensembles with neocortical memory traces to convert episodic memories to semantic knowledge and is believed to rely on coordinated interactions between sharp wave-ripples (SPWRs) and K-complexes (KCs). The aim of my study was to investigate whether inactivation of reuniens affects SPWR and KC coordination. I found that dialysis of lidocaine into reuniens did not affect the coordination of KCs and SPWRs. While previous studies have demonstrated effective local neural inactivation using lidocaine dialysis, I did not observe any effects that could be used to positively verify a drug effect. The data thus tentatively provide evidence that reuniens does not coordinate KSs and SPWRs. Future studies will be needed using methods for which inactivation can be positively identified."]},{"key":"dc:title","label":"Title","values":["The effect of nucleus reuniens inactivation on neocortical K-complex and hippocampal sharp wave-ripple correlations"]}]}],"canonical_facts":{"dc:contributor.supervisor":["McNaughton, Bruce L."],"dc:creator":["Kesler, Mitchell T.","University of Lethbridge. Faculty of Arts and Science"],"dc:date.accessioned":["2017-03-06T18:04:00Z"],"dc:date.available":["2017-03-06T18:04:00Z"],"dc:date.issued":["2016"],"dc:description.abstract":["Cortico-hippocampal communication is critical for cognitive processes including behavioural flexibility, and memory formation, consolidation, and retrieval. Nucleus reuniens of the thalamus has been implicated in memory consolidation. Consolidation involves the reactivation of hippocampal ensembles with neocortical memory traces to convert episodic memories to semantic knowledge and is believed to rely on coordinated interactions between sharp wave-ripples (SPWRs) and K-complexes (KCs). The aim of my study was to investigate whether inactivation of reuniens affects SPWR and KC coordination. I found that dialysis of lidocaine into reuniens did not affect the coordination of KCs and SPWRs. While previous studies have demonstrated effective local neural inactivation using lidocaine dialysis, I did not observe any effects that could be used to positively verify a drug effect. The data thus tentatively provide evidence that reuniens does not coordinate KSs and SPWRs. Future studies will be needed using methods for which inactivation can be positively identified."],"dc:description.other":["Cortico-hippocampal communication is critical for cognitive processes including behavioural flexibility, and memory formation, consolidation, and retrieval. Nucleus reuniens of the thalamus has been implicated in memory consolidation. Consolidation involves the reactivation of hippocampal ensembles with neocortical memory traces to convert episodic memories to semantic knowledge and is believed to rely on coordinated interactions between sharp wave-ripples (SPWRs) and K-complexes (KCs). The aim of my study was to investigate whether inactivation of reuniens affects SPWR and KC coordination. I found that dialysis of lidocaine into reuniens did not affect the coordination of KCs and SPWRs. While previous studies have demonstrated effective local neural inactivation using lidocaine dialysis, I did not observe any effects that could be used to positively verify a drug effect. The data thus tentatively provide evidence that reuniens does not coordinate KSs and SPWRs. Future studies will be needed using methods for which inactivation can be positively identified."],"dc:identifier":["hdl:10133/4790"],"dc:identifier.uri":["https://hdl.handle.net/10133/4790"],"dc:language.iso":["en_US"],"dc:publisher":["Lethbridge, Alta : University of Lethbridge, Dept. of Neuroscience"],"dc:publisher.department":["Department of Neuroscience"],"dc:subject":["KCs","lidocaine dialysis","medioventral nucleus","memory consolidation","mPFC","SPWRs"],"dc:title":["The effect of nucleus reuniens inactivation on neocortical K-complex and hippocampal sharp wave-ripple correlations"],"dc:type":["Thesis"]},"updated_at":"2026-08-21T16:45:58Z"}