{"id":{"repo_id":"lethbridge","oai_identifier":"oai:opus.uleth.ca:10133/4599"},"canonical_url":"https://search.dev.ndltd.org/etd/lethbridge/oai:opus.uleth.ca:10133/4599","repository":{"repo_id":"lethbridge","name":"University of Lethbridge","base_url":"https://opus.uleth.ca/server/oai/request"},"display":{"title":"The influence of drugs of abuse on reward-based decision-making","abstract":"Animals are thought to learn from reinforcement by a dopamine-dependent reward prediction error, based on the difference between the expected and actual value of a reward. Here we demonstrate that this learning signal can be manipulated by drugs of abuse (amphetamine and Δ-9-tetrahydrocannabinol), resulting in reduced loss sensitivity on a competitive binary choice task. This effect is distinct from global choice strategy, as the randomness of choice responding is unaffected by drug and animals with on-board Δ-9-tetrahydrocannabinol are still capable of flexibly tracking changing reward contingencies. Furthermore, we demonstrate that lose-shift responding is increased following amphetamine sensitization. We propose this increase is indicative of drug-induced plastic changes facilitating a shift in behavioral control towards dorsolateral striatum. These results highlight the potential for drugs of abuse to alter reward-based decision-making and provide a novel measure of the shift in behavioral control towards dorsolateral striatum that is proposed to occur in addiction.","abstract_html":"Animals are thought to learn from reinforcement by a dopamine-dependent reward prediction error, based on the difference between the expected and actual value of a reward. Here we demonstrate that this learning signal can be manipulated by drugs of abuse (amphetamine and Δ-9-tetrahydrocannabinol), resulting in reduced loss sensitivity on a competitive binary choice task. This effect is distinct from global choice strategy, as the randomness of choice responding is unaffected by drug and animals with on-board Δ-9-tetrahydrocannabinol are still capable of flexibly tracking changing reward contingencies. Furthermore, we demonstrate that lose-shift responding is increased following amphetamine sensitization. We propose this increase is indicative of drug-induced plastic changes facilitating a shift in behavioral control towards dorsolateral striatum. These results highlight the potential for drugs of abuse to alter reward-based decision-making and provide a novel measure of the shift in behavioral control towards dorsolateral striatum that is proposed to occur in addiction.","abstract_has_math":false,"creators":["Wong, Scott","University of Lethbridge. Faculty of Arts and Science"],"institution":null,"degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2016,"date_issued":"2016","date_published":"2016","updated_at":"2026-07-27T20:02:38Z","subjects":["addiction","dopamine","reinforcement learning"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["hdl:10133/4599"],"render_values":[{"text":"hdl:10133/4599","href":null,"code":true}]}]},"links":{"outbound_url":null,"outbound_label":null,"outbound_source":null},"metadata_groups":[{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.issued","label":"Date","values":["2016"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["addiction","dopamine","reinforcement learning"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["hdl:10133/4599"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.other","label":"Dc Description Other","values":["Animals are thought to learn from reinforcement by a dopamine-dependent reward prediction error, based on the difference between the expected and actual value of a reward. Here we demonstrate that this learning signal can be manipulated by drugs of abuse (amphetamine and Δ-9-tetrahydrocannabinol), resulting in reduced loss sensitivity on a competitive binary choice task. This effect is distinct from global choice strategy, as the randomness of choice responding is unaffected by drug and animals with on-board Δ-9-tetrahydrocannabinol are still capable of flexibly tracking changing reward contingencies. Furthermore, we demonstrate that lose-shift responding is increased following amphetamine sensitization. We propose this increase is indicative of drug-induced plastic changes facilitating a shift in behavioral control towards dorsolateral striatum. These results highlight the potential for drugs of abuse to alter reward-based decision-making and provide a novel measure of the shift in behavioral control towards dorsolateral striatum that is proposed to occur in addiction."]},{"key":"dc:title","label":"Title","values":["The influence of drugs of abuse on reward-based decision-making"]}]}],"canonical_facts":{"dc:date.issued":["2016"],"dc:description.other":["Animals are thought to learn from reinforcement by a dopamine-dependent reward prediction error, based on the difference between the expected and actual value of a reward. Here we demonstrate that this learning signal can be manipulated by drugs of abuse (amphetamine and Δ-9-tetrahydrocannabinol), resulting in reduced loss sensitivity on a competitive binary choice task. This effect is distinct from global choice strategy, as the randomness of choice responding is unaffected by drug and animals with on-board Δ-9-tetrahydrocannabinol are still capable of flexibly tracking changing reward contingencies. Furthermore, we demonstrate that lose-shift responding is increased following amphetamine sensitization. We propose this increase is indicative of drug-induced plastic changes facilitating a shift in behavioral control towards dorsolateral striatum. These results highlight the potential for drugs of abuse to alter reward-based decision-making and provide a novel measure of the shift in behavioral control towards dorsolateral striatum that is proposed to occur in addiction."],"dc:identifier":["hdl:10133/4599"],"dc:subject":["addiction","dopamine","reinforcement learning"],"dc:title":["The influence of drugs of abuse on reward-based decision-making"],"dc:type":["Thesis"]},"updated_at":"2026-07-27T20:02:38Z"}