{"id":{"repo_id":"laurentian","oai_identifier":"oai:laurentian.scholaris.ca:10219/3600"},"canonical_url":"https://search.dev.ndltd.org/etd/laurentian/oai:laurentian.scholaris.ca:10219/3600","repository":{"repo_id":"laurentian","name":"Laurentian University","base_url":"https://laurentian.scholaris.ca/server/oai/request"},"display":{"title":"The protective role of hydrogen sulfide from obesity-associated metabolic stress in GLP-1 regulation","abstract":"Circulating palmitic acid (PA) and glycated albumin (GA) are increased in obesity and cause metabolic stress leading to diabetes. This includes the impairment of the glucoregulatory hormone glucagon-like peptide-1 (GLP-1) secreted from intestinal L-cells. Recently, the gasotransmitter hydrogen sulfide (H2S) has been implicated in the enhancement of GLP-1 secretion. We hypothesized that H2S can reduce the oxidative stress caused by PA and GA, and play a protective role in L-cell function. In mouse and human L-cell models, PA and GA caused an increase in reactive oxygen species (ROS). The H2S donor GYY4137 partially blocked PA- ROS induction. In mice, PA-enriched Western diet (WD) elevated body weight in both sexes and elevated fasting blood glucose and lipid peroxidation in males. A single GYY4137 injection improved oral glucose tolerance in WD-fed male mice and also enhanced glucose-stimulated GLP-1 release. To conclude, H2S reduces oxidative stress in GLP-1 cells and can improve glucose clearance in mice.","abstract_html":"Circulating palmitic acid (PA) and glycated albumin (GA) are increased in obesity and cause metabolic stress leading to diabetes. This includes the impairment of the glucoregulatory hormone glucagon-like peptide-1 (GLP-1) secreted from intestinal L-cells. Recently, the gasotransmitter hydrogen sulfide (H2S) has been implicated in the enhancement of GLP-1 secretion. We hypothesized that H2S can reduce the oxidative stress caused by PA and GA, and play a protective role in L-cell function. In mouse and human L-cell models, PA and GA caused an increase in reactive oxygen species (ROS). The H2S donor GYY4137 partially blocked PA- ROS induction. In mice, PA-enriched Western diet (WD) elevated body weight in both sexes and elevated fasting blood glucose and lipid peroxidation in males. A single GYY4137 injection improved oral glucose tolerance in WD-fed male mice and also enhanced glucose-stimulated GLP-1 release. To conclude, H2S reduces oxidative stress in GLP-1 cells and can improve glucose clearance in mice.","abstract_has_math":false,"creators":["Mezouari, Ania"],"institution":"Laurentian University of Sudbury","degree_name":"Master of Science (MSc) in Biology","degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2020,"date_issued":"2020-10-19","date_published":"2020-10-19","updated_at":"2026-08-21T16:45:57Z","subjects":["Palmitic acid","glycated albumin","GLP-1,","hydrogen sulfide","oxidative stress"],"languages":["en"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://laurentian.scholaris.ca/handle/10219/3600","outbound_label":"Repository record","outbound_source":"dc:identifier.uri"},"source_record":{"url":"https://laurentian.scholaris.ca/server/oai/request?verb=GetRecord&metadataPrefix=dim&identifier=oai%3Alaurentian.scholaris.ca%3A10219%2F3600","prefix":"dim"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Mezouari, Ania"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2020-11-10T15:11:38Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2020-11-10T15:11:38Z"]},{"key":"dc:date.issued","label":"Date","values":["2020-10-19"]},{"key":"dc:publisher","label":"Institution","values":["Laurentian University of Sudbury"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Master of Science (MSc) in Biology"]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["Laurentian University of Sudbury"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Palmitic acid","glycated albumin","GLP-1,","hydrogen sulfide","oxidative stress"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["https://laurentian.scholaris.ca/handle/10219/3600"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Circulating palmitic acid (PA) and glycated albumin (GA) are increased in obesity and cause metabolic stress leading to diabetes. This includes the impairment of the glucoregulatory hormone glucagon-like peptide-1 (GLP-1) secreted from intestinal L-cells. Recently, the gasotransmitter hydrogen sulfide (H2S) has been implicated in the enhancement of GLP-1 secretion. We hypothesized that H2S can reduce the oxidative stress caused by PA and GA, and play a protective role in L-cell function. In mouse and human L-cell models, PA and GA caused an increase in reactive oxygen species (ROS). The H2S donor GYY4137 partially blocked PA- ROS induction. In mice, PA-enriched Western diet (WD) elevated body weight in both sexes and elevated fasting blood glucose and lipid peroxidation in males. A single GYY4137 injection improved oral glucose tolerance in WD-fed male mice and also enhanced glucose-stimulated GLP-1 release. To conclude, H2S reduces oxidative stress in GLP-1 cells and can improve glucose clearance in mice."]},{"key":"dc:title","label":"Title","values":["The protective role of hydrogen sulfide from obesity-associated metabolic stress in GLP-1 regulation"]}]}],"canonical_facts":{"dc:creator":["Mezouari, Ania"],"dc:date.accessioned":["2020-11-10T15:11:38Z"],"dc:date.available":["2020-11-10T15:11:38Z"],"dc:date.issued":["2020-10-19"],"dc:description.abstract":["Circulating palmitic acid (PA) and glycated albumin (GA) are increased in obesity and cause metabolic stress leading to diabetes. This includes the impairment of the glucoregulatory hormone glucagon-like peptide-1 (GLP-1) secreted from intestinal L-cells. Recently, the gasotransmitter hydrogen sulfide (H2S) has been implicated in the enhancement of GLP-1 secretion. We hypothesized that H2S can reduce the oxidative stress caused by PA and GA, and play a protective role in L-cell function. In mouse and human L-cell models, PA and GA caused an increase in reactive oxygen species (ROS). The H2S donor GYY4137 partially blocked PA- ROS induction. In mice, PA-enriched Western diet (WD) elevated body weight in both sexes and elevated fasting blood glucose and lipid peroxidation in males. A single GYY4137 injection improved oral glucose tolerance in WD-fed male mice and also enhanced glucose-stimulated GLP-1 release. To conclude, H2S reduces oxidative stress in GLP-1 cells and can improve glucose clearance in mice."],"dc:identifier.uri":["https://laurentian.scholaris.ca/handle/10219/3600"],"dc:language.iso":["en"],"dc:publisher":["Laurentian University of Sudbury"],"dc:subject":["Palmitic acid","glycated albumin","GLP-1,","hydrogen sulfide","oxidative stress"],"dc:title":["The protective role of hydrogen sulfide from obesity-associated metabolic stress in GLP-1 regulation"],"dc:type":["Thesis"],"thesis:degree_name":["Master of Science (MSc) in Biology"],"thesis:institution_name":["Laurentian University of Sudbury"]},"updated_at":"2026-08-21T16:45:57Z"}