{"id":{"repo_id":"laurentian","oai_identifier":"oai:laurentian.scholaris.ca:10219/2486"},"canonical_url":"https://search.dev.ndltd.org/etd/laurentian/oai:laurentian.scholaris.ca:10219/2486","repository":{"repo_id":"laurentian","name":"Laurentian University","base_url":"https://laurentian.scholaris.ca/server/oai/request"},"display":{"title":"The role of FGF growth factors in the development of chemotherapy drug resistance in ovarian cancer cells.","abstract":"Ovarian cancer is the most gynecological cancer, it has a 5-year mortality rate greater than 70%. When ovarian cancer patients undergo chemotherapy their gene expression changes. This project is studying a particular group of genes called Fibroblast Growth Factors (FGFs), which have been found to be very important in cancer. The hypothesis predicted that significant changes in the expression of FGF proteins are associated with the development of drug resistance in ovarian cancer. Previous work developed three resistant cell lines from the A2780 ovarian cancer cell line (A2780CBN, A2780DXL, A2780CBNDXL), In the previous studies, microarray analysis was performed to find changes in gene expression in the three cell lines. We have been able to confirm some of the changes that indicated a possible role for FGF gene expression changes in drug resistance. However, we could only confirm a change in protein expression for one of the FGF factors, FGF23, which was altered in A2780CBN and A2780CBNDXL resistant cell lines.","abstract_html":"Ovarian cancer is the most gynecological cancer, it has a 5-year mortality rate greater than 70%. When ovarian cancer patients undergo chemotherapy their gene expression changes. This project is studying a particular group of genes called Fibroblast Growth Factors (FGFs), which have been found to be very important in cancer. The hypothesis predicted that significant changes in the expression of FGF proteins are associated with the development of drug resistance in ovarian cancer. Previous work developed three resistant cell lines from the A2780 ovarian cancer cell line (A2780CBN, A2780DXL, A2780CBNDXL), In the previous studies, microarray analysis was performed to find changes in gene expression in the three cell lines. We have been able to confirm some of the changes that indicated a possible role for FGF gene expression changes in drug resistance. However, we could only confirm a change in protein expression for one of the FGF factors, FGF23, which was altered in A2780CBN and A2780CBNDXL resistant cell lines.","abstract_has_math":false,"creators":["Alharbi, Albatul Awadh"],"institution":"Laurentian University of Sudbury","degree_name":"Master of Science (M.Sc.) in Biology","degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2015,"date_issued":"2015-08-31","date_published":"2015-08-31","updated_at":"2026-08-21T16:45:55Z","subjects":["Ovarian cancer","Chemotherapy","Fibroblast Growth Factors (FGFs)","Gene expression","Expression of FGF proteins","Drug resistance","Three cell lines"],"languages":["en"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://laurentian.scholaris.ca/handle/10219/2486","outbound_label":"Repository record","outbound_source":"dc:identifier.uri"},"source_record":{"url":"https://laurentian.scholaris.ca/server/oai/request?verb=GetRecord&metadataPrefix=dim&identifier=oai%3Alaurentian.scholaris.ca%3A10219%2F2486","prefix":"dim"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Alharbi, Albatul Awadh"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2015-10-13T15:18:42Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2015-10-13T15:18:42Z"]},{"key":"dc:date.issued","label":"Date","values":["2015-08-31"]},{"key":"dc:publisher","label":"Institution","values":["Laurentian University of Sudbury"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Master of Science (M.Sc.) in Biology"]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["Laurentian University of Sudbury"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Ovarian cancer","Chemotherapy","Fibroblast Growth Factors (FGFs)","Gene expression","Expression of FGF proteins","Drug resistance","Three cell lines"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["https://laurentian.scholaris.ca/handle/10219/2486"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Ovarian cancer is the most gynecological cancer, it has a 5-year mortality rate greater than 70%. When ovarian cancer patients undergo chemotherapy their gene expression changes. This project is studying a particular group of genes called Fibroblast Growth Factors (FGFs), which have been found to be very important in cancer. The hypothesis predicted that significant changes in the expression of FGF proteins are associated with the development of drug resistance in ovarian cancer. Previous work developed three resistant cell lines from the A2780 ovarian cancer cell line (A2780CBN, A2780DXL, A2780CBNDXL), In the previous studies, microarray analysis was performed to find changes in gene expression in the three cell lines. We have been able to confirm some of the changes that indicated a possible role for FGF gene expression changes in drug resistance. However, we could only confirm a change in protein expression for one of the FGF factors, FGF23, which was altered in A2780CBN and A2780CBNDXL resistant cell lines."]},{"key":"dc:title","label":"Title","values":["The role of FGF growth factors in the development of chemotherapy drug resistance in ovarian cancer cells."]}]}],"canonical_facts":{"dc:creator":["Alharbi, Albatul Awadh"],"dc:date.accessioned":["2015-10-13T15:18:42Z"],"dc:date.available":["2015-10-13T15:18:42Z"],"dc:date.issued":["2015-08-31"],"dc:description.abstract":["Ovarian cancer is the most gynecological cancer, it has a 5-year mortality rate greater than 70%. When ovarian cancer patients undergo chemotherapy their gene expression changes. This project is studying a particular group of genes called Fibroblast Growth Factors (FGFs), which have been found to be very important in cancer. The hypothesis predicted that significant changes in the expression of FGF proteins are associated with the development of drug resistance in ovarian cancer. Previous work developed three resistant cell lines from the A2780 ovarian cancer cell line (A2780CBN, A2780DXL, A2780CBNDXL), In the previous studies, microarray analysis was performed to find changes in gene expression in the three cell lines. We have been able to confirm some of the changes that indicated a possible role for FGF gene expression changes in drug resistance. However, we could only confirm a change in protein expression for one of the FGF factors, FGF23, which was altered in A2780CBN and A2780CBNDXL resistant cell lines."],"dc:identifier.uri":["https://laurentian.scholaris.ca/handle/10219/2486"],"dc:language.iso":["en"],"dc:publisher":["Laurentian University of Sudbury"],"dc:subject":["Ovarian cancer","Chemotherapy","Fibroblast Growth Factors (FGFs)","Gene expression","Expression of FGF proteins","Drug resistance","Three cell lines"],"dc:title":["The role of FGF growth factors in the development of chemotherapy drug resistance in ovarian cancer cells."],"dc:type":["Thesis"],"thesis:degree_name":["Master of Science (M.Sc.) in Biology"],"thesis:institution_name":["Laurentian University of Sudbury"]},"updated_at":"2026-08-21T16:45:55Z"}