DIETARY FACTORS ASSOCIATED WITH THE PROGRESSION OF AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE
type: CreativeWork
description: Introduction: Dietary factors (sodium, protein, acid precursors, and fluid) have been observed to influence cyst growth in human and animal studies of autosomal dominant polycystic kidney disease (ADPKD). However, no studies have been conducted to control such dietary constituents. Body mass index (BMI) and high-density lipoprotein (HDL), factors associated with dietary behaviors, have also been reported to associate with ADPKD progression and warrant further examination. The following series of studies aimed to (1) determine whether patients could adhere to a low sodium, low protein, low acid precursor diet with increased fluid intake; (2) understand participants’ experiences and perspectives as they attempted to follow the diet; (3) reveal potential barriers that may reduce the likelihood of long-term adherence; (4) determine if data obtained from the electronic health record (EHR) can be used to identify risk factors associated with ADPKD progression (BMI and HDL). Methods: A four-week dietary intervention was conducted to determine if a relatively complex dietary prescription targeting salt, protein, acid precursors, and fluid intake would be adopted by adult patients with ADPKD. Consecutive 24-hour urine collections were analyzed for sodium, urea, net acid excretion (NAE), urine volume, and osmolality. Three-day diet records were analyzed for sodium, protein, net endogenous acid production (NEAP), and fluid intake. A basic metabolic panel was obtained from blood samples. Blood pressure, height, and weight were obtained by a nurse at each visit. Outcomes were measured at baseline, two weeks, and four weeks. Following the dietary intervention, interviews and a Nutrition Hassles Questionnaire (NHQ) were conducted with participants to determine how difficult it was for them to follow the diet. Finally, we collected BMI and HDL levels from the EHRs of ADPKD patients seen at the University of Kansas Medical Center and determined their associations with the age of rea…
abstract: Introduction: Dietary factors (sodium, protein, acid precursors, and fluid) have been observed to influence cyst growth in human and animal studies of autosomal dominant polycystic kidney disease (ADPKD). However, no studies have been conducted to control such dietary constituents. Body mass index (BMI) and high-density lipoprotein (HDL), factors associated with dietary behaviors, have also been reported to associate with ADPKD progression and warrant further examination. The following series of studies aimed to (1) determine whether patients could adhere to a low sodium, low protein, low acid precursor diet with increased fluid intake; (2) understand participants’ experiences and perspectives as they attempted to follow the diet; (3) reveal potential barriers that may reduce the likelihood of long-term adherence; (4) determine if data obtained from the electronic health record (EHR) can be used to identify risk factors associated with ADPKD progression (BMI and HDL). Methods: A four-week dietary intervention was conducted to determine if a relatively complex dietary prescription targeting salt, protein, acid precursors, and fluid intake would be adopted by adult patients with ADPKD. Consecutive 24-hour urine collections were analyzed for sodium, urea, net acid excretion (NAE), urine volume, and osmolality. Three-day diet records were analyzed for sodium, protein, net endogenous acid production (NEAP), and fluid intake. A basic metabolic panel was obtained from blood samples. Blood pressure, height, and weight were obtained by a nurse at each visit. Outcomes were measured at baseline, two weeks, and four weeks. Following the dietary intervention, interviews and a Nutrition Hassles Questionnaire (NHQ) were conducted with participants to determine how difficult it was for them to follow the diet. Finally, we collected BMI and HDL levels from the EHRs of ADPKD patients seen at the University of Kansas Medical Center and determined their associations with the age of rea…
author: Taylor, Jacob M.
language: en
keywords: Nutrition, Health sciences, dietary acid load, net acid excretion, net endogenous acid production, polycystic kidney disease, potential renal acid load, renal nutrition
date published: 2015-12-31
date modified: 2026-07-24T02:45:07Z
provider: University of Kansas
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: University of Kansas

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property ID: Handle
value: http://hdl.handle.net/1808/25637