Blinded, randomized, placebo-controlled study of the efficacy of bupivacaine liposomal suspension using static body weight distribution and subjective pain scoring in dogs after tibial plateau leveling osteotomy (TPLO) surgery

Objective: To compare the analgesic effect of surgical wound infiltration with liposomal bupivacaine (LB) to saline placebo in dogs after tibial plateau leveling osteotomy (TPLO). Study Design: Blinded, randomized, placebo-controlled clinical prospective study Animals: 15 client-owned dogs receiving liposomal bupivacaine and 17 dogs receiving an equivalent volume of saline placebo, all with confirmed unilateral cranial cruciate ligament insufficiency. Methods: Preoperatively and up to 48 hours after surgery, Glasgow Composite Measure Short Form (CMPS-SF) pain scores were assigned and using a weight distribution platform, static body weight distribution (%BW[subsctipt dist]) to the operated limb was measured. Postoperatively, dogs also received carprofen 2.2 mg/kg subcutaneously every 12 hours. Rescue analgesia was provided. Treatment success was defined as not requiring rescue analgesia over the 48 hour postoperative period. Results: There was no difference between treatment success, postoperative opioid consumption, CMPS-SF pain scores, or %BW[subscript dist] in dogs that received surgical wound infiltration with LB compared with those receiving saline placebo, following TPLO. There was no linear correlation between CMPS-SF pain scores and %BW[subscript dist]. Conclusion: For the population of dogs that underwent TPLO and received postoperative carprofen at our institution, LB did not provide an analgesic effect discernable by success/failure analysis, CMPS-SF pain scores, or %BW[subscript dist] measurement using a weight distribution platform, compared with saline placebo. Clinical Significance (or Impact): LB may not provide detectable analgesia for dogs recovering from TPLO and receiving postoperative carprofen.

Grantor dc:publisher

Kansas State University

Year dc:date.issued

2021

Author dc:creator

• Aldrich, Lauren A.

• Liposomal bupivacaine
• Canine

Statement dc:rights

• © the author. This Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s).

Licence dc:rights.uri

• http://rightsstatements.org/vocab/InC/1.0/

Language dc:language.iso

en_US

Handle dc:identifier.uri

https://hdl.handle.net/2097/41687

OAI identifier oai:identifier

oai:krex.k-state.edu:2097/41687