{"id":{"repo_id":"iupui","oai_identifier":"oai:scholarworks.indianapolis.iu.edu:1805/4377"},"canonical_url":"https://search.dev.ndltd.org/etd/iupui/oai:scholarworks.indianapolis.iu.edu:1805/4377","repository":{"repo_id":"iupui","name":"IUPUI","base_url":"https://scholarworks.indianapolis.iu.edu/server/oai/request"},"display":{"title":"A comparison of IgA antibody levels in caries-resistant and caries-susceptible children","abstract":"Secretory immunity is believed to play a role in natural resistance to dental caries. Although dental caries has dramatically decreased in children in the United States, there remains a population of caries-susceptible children even in fluoridated communities. Previous studies have shown a positive correlation between salivary immunoglobulin A (sIgA) antibody levels to Streptococcus mutans and caries resistance in adults. In the present study, an enzyme-linked immunosorbent assay (ELISA) was used to compare IgA antibody levels to S. mutans in saliva from 20 caries susceptible (DMFS greater than 5) and 20 caries-resistant (DMFS less than or equal to 1) children (ages 7-11). All subjects resided in fluoridated communities. Salivary S. mutans numbers were significantly higher (p ≤ 0.05) in the caries susceptible (31.2 percent of total streptococci) group than in the caries resistant (1.6 percent of total streptococci) group. Whole saliva from caries-resistant children had significantly higher (p = 0.05) levels of IgA antibodies to S. mutans than saliva from caries-susceptible children. However, whole saliva from caries-resistant children had similar levels of IgA1 or IgA2 antibodies against S. mutans to saliva from caries-susceptible children. These results suggest that IgA antibody to S. mutans may play a role in natural protection from dental caries in children and confirm previous reports indicating a role for salivary IgA antibodies to S. mutans in mediation of caries.","abstract_html":"Secretory immunity is believed to play a role in natural resistance to dental caries. Although dental caries has dramatically decreased in children in the United States, there remains a population of caries-susceptible children even in fluoridated communities. Previous studies have shown a positive correlation between salivary immunoglobulin A (sIgA) antibody levels to Streptococcus mutans and caries resistance in adults. In the present study, an enzyme-linked immunosorbent assay (ELISA) was used to compare IgA antibody levels to S. mutans in saliva from 20 caries susceptible (DMFS greater than 5) and 20 caries-resistant (DMFS less than or equal to 1) children (ages 7-11). All subjects resided in fluoridated communities. Salivary S. mutans numbers were significantly higher (p ≤ 0.05) in the caries susceptible (31.2 percent of total streptococci) group than in the caries resistant (1.6 percent of total streptococci) group. Whole saliva from caries-resistant children had significantly higher (p = 0.05) levels of IgA antibodies to S. mutans than saliva from caries-susceptible children. However, whole saliva from caries-resistant children had similar levels of IgA1 or IgA2 antibodies against S. mutans to saliva from caries-susceptible children. These results suggest that IgA antibody to S. mutans may play a role in natural protection from dental caries in children and confirm previous reports indicating a role for salivary IgA antibodies to S. mutans in mediation of caries.","abstract_has_math":false,"creators":["Rose, Paul Todd"],"institution":null,"degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":["Hughes, Christopher V."],"committee_chairs":[],"committee_members":[],"year":1993,"date_issued":"1993","date_published":"1993","updated_at":"2026-07-24T02:41:41Z","subjects":[],"languages":["en_US"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://dx.doi.org/10.7912/C2/1626"],"render_values":[{"text":"http://dx.doi.org/10.7912/C2/1626","href":"http://dx.doi.org/10.7912/C2/1626","code":true}]}]},"links":{"outbound_url":"https://hdl.handle.net/1805/4377","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Hughes, Christopher V."]},{"key":"dc:contributor.other","label":"Dc Contributor Other","values":["Avery, David R.","Sanders, Brian J.","Branca, Ronald A.","Gregory, Richard L."]},{"key":"dc:creator","label":"Author","values":["Rose, Paul Todd"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2014-04-24T19:36:49Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2014-04-24T19:36:49Z"]},{"key":"dc:date.issued","label":"Date","values":["1993"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en_US"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["https://hdl.handle.net/1805/4377","http://dx.doi.org/10.7912/C2/1626"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Indiana University-Purdue University Indianapolis (IUPUI)"]},{"key":"dc:description.abstract","label":"Abstract","values":["Secretory immunity is believed to play a role in natural resistance to dental caries. Although dental caries has dramatically decreased in children in the United States, there remains a population of caries-susceptible children even in fluoridated communities. Previous studies have shown a positive correlation between salivary immunoglobulin A (sIgA) antibody levels to Streptococcus mutans and caries resistance in adults. In the present study, an enzyme-linked immunosorbent assay (ELISA) was used to compare IgA antibody levels to S. mutans in saliva from 20 caries susceptible (DMFS greater than 5) and 20 caries-resistant (DMFS less than or equal to 1) children (ages 7-11). All subjects resided in fluoridated communities. Salivary S. mutans numbers were significantly higher (p ≤ 0.05) in the caries susceptible (31.2 percent of total streptococci) group than in the caries resistant (1.6 percent of total streptococci) group. Whole saliva from caries-resistant children had significantly higher (p = 0.05) levels of IgA antibodies to S. mutans than saliva from caries-susceptible children. However, whole saliva from caries-resistant children had similar levels of IgA1 or IgA2 antibodies against S. mutans to saliva from caries-susceptible children. These results suggest that IgA antibody to S. mutans may play a role in natural protection from dental caries in children and confirm previous reports indicating a role for salivary IgA antibodies to S. mutans in mediation of caries."]},{"key":"dc:title","label":"Title","values":["A comparison of IgA antibody levels in caries-resistant and caries-susceptible children"]}]}],"canonical_facts":{"dc:contributor.advisor":["Hughes, Christopher V."],"dc:contributor.other":["Avery, David R.","Sanders, Brian J.","Branca, Ronald A.","Gregory, Richard L."],"dc:creator":["Rose, Paul Todd"],"dc:date.accessioned":["2014-04-24T19:36:49Z"],"dc:date.available":["2014-04-24T19:36:49Z"],"dc:date.issued":["1993"],"dc:description":["Indiana University-Purdue University Indianapolis (IUPUI)"],"dc:description.abstract":["Secretory immunity is believed to play a role in natural resistance to dental caries. Although dental caries has dramatically decreased in children in the United States, there remains a population of caries-susceptible children even in fluoridated communities. Previous studies have shown a positive correlation between salivary immunoglobulin A (sIgA) antibody levels to Streptococcus mutans and caries resistance in adults. In the present study, an enzyme-linked immunosorbent assay (ELISA) was used to compare IgA antibody levels to S. mutans in saliva from 20 caries susceptible (DMFS greater than 5) and 20 caries-resistant (DMFS less than or equal to 1) children (ages 7-11). All subjects resided in fluoridated communities. Salivary S. mutans numbers were significantly higher (p ≤ 0.05) in the caries susceptible (31.2 percent of total streptococci) group than in the caries resistant (1.6 percent of total streptococci) group. Whole saliva from caries-resistant children had significantly higher (p = 0.05) levels of IgA antibodies to S. mutans than saliva from caries-susceptible children. However, whole saliva from caries-resistant children had similar levels of IgA1 or IgA2 antibodies against S. mutans to saliva from caries-susceptible children. These results suggest that IgA antibody to S. mutans may play a role in natural protection from dental caries in children and confirm previous reports indicating a role for salivary IgA antibodies to S. mutans in mediation of caries."],"dc:identifier.uri":["https://hdl.handle.net/1805/4377","http://dx.doi.org/10.7912/C2/1626"],"dc:language.iso":["en_US"],"dc:title":["A comparison of IgA antibody levels in caries-resistant and caries-susceptible children"],"dc:type":["Thesis"]},"updated_at":"2026-07-24T02:41:41Z"}