Facilitating Pharmacogenetic Association Studies Using an Extensible Genotype Information Management System

Large-scale genome data projects employing automated, high-throughput techniques have led to a deluge of genomic data that necessitate robust informatic solutions. COBRA-DB is an integrated web-based genome information management system that provides storage for pharmacogenomic information including genotypic, phenotypic and resequencing data. The system provides an integrated solution for the acquisition, organization, storage, retrieval and analysis of pharmacogenomic data and offers a platform for genome annotation and analysis. The system also includes an export utility to automate submission of data to other bioinformatic resources and public data repositories. A web interface provides flexible data import and export options and allows users to access and download data via simple query forms. The COBRA database is dedicated to the efficient management of pharmacogenomic data with the intent to facilitate genotype-phenotype association studies and catalyze pharmacogenomic research. COBRA-DB is an internal, proprietary application in use by the Division of Clinical Pharmacology at Indiana University School of Medicine.

Author dc:creator

• Fletcher, Rebecca

Advisor dc:contributor.advisor

• Mooney, Sean D.

Language dc:language.iso

en_US

Identifier URI

http://dx.doi.org/10.7912/C2/806

OAI identifier oai:identifier

oai:scholarworks.indianapolis.iu.edu:1805/1998