The influence of baseline hardness and chemical composition on enamel demineralization and subsequent remineralization
type: CreativeWork
description: BACKGROUND Several studies have reported that harder enamel with higher contents of calcium (Ca), phosphorus (P) and fluorine (F) coupled with lower contents of carbonate (C), magnesium (Mg) and nitrate (N) was found to be more resistant to demineralization. Additionally, the hardness of dental enamel was found to have a strong correlation with its chemical content. However, yet to be established is the relation between the physical and chemical structure of enamel and its response to de- and remineralizing conditions. OBJECTIVES The aims of this laboratory study were: 1) To investigate the hardness and chemical content of sound enamel and their influence on demineralization; 2) To investigate these properties in demineralized enamel and their influence on remineralization; and 3) To investigate these properties in sound enamel and their influence on remineralization. MATERIALS AND METHODS Incipient subsurface caries lesions were created in 94 bovine enamel specimens using Carbopol C907 using three demineralization times. The specimens were then pH-cycled and treated using either 367 ppm F sodium fluoride or a placebo. Knoop surface microhardness (SMH), Energy dispersive X-ray spectroscopy (EDS) and Transverse microradiography (TMR) were performed on the specimens at all stages and compared between them. TMR variables included integrated mineral loss (ΔZ), Lesion depth (L) and maximum mineral density of the surface zone (SZmax). Data were analyzed using three- and four-way ANOVA and Pearson correlation coefficients were calculated. RESULTS SMH, ΔZ, L and SZmax were significantly different among stages, demineralization times and treatment. The weight% of F at the surface was significantly affected by treatment, irrespective of demineralization time. A statistically significant moderate correlation was found between SZmax and ΔZ and SZmax and L after pH cycling. SMH also correlated weakly to moderately with TMR data. CONCLUSIONS SMH and SZmax decreased while ΔZ and L…
abstract: BACKGROUND Several studies have reported that harder enamel with higher contents of calcium (Ca), phosphorus (P) and fluorine (F) coupled with lower contents of carbonate (C), magnesium (Mg) and nitrate (N) was found to be more resistant to demineralization. Additionally, the hardness of dental enamel was found to have a strong correlation with its chemical content. However, yet to be established is the relation between the physical and chemical structure of enamel and its response to de- and remineralizing conditions. OBJECTIVES The aims of this laboratory study were: 1) To investigate the hardness and chemical content of sound enamel and their influence on demineralization; 2) To investigate these properties in demineralized enamel and their influence on remineralization; and 3) To investigate these properties in sound enamel and their influence on remineralization. MATERIALS AND METHODS Incipient subsurface caries lesions were created in 94 bovine enamel specimens using Carbopol C907 using three demineralization times. The specimens were then pH-cycled and treated using either 367 ppm F sodium fluoride or a placebo. Knoop surface microhardness (SMH), Energy dispersive X-ray spectroscopy (EDS) and Transverse microradiography (TMR) were performed on the specimens at all stages and compared between them. TMR variables included integrated mineral loss (ΔZ), Lesion depth (L) and maximum mineral density of the surface zone (SZmax). Data were analyzed using three- and four-way ANOVA and Pearson correlation coefficients were calculated. RESULTS SMH, ΔZ, L and SZmax were significantly different among stages, demineralization times and treatment. The weight% of F at the surface was significantly affected by treatment, irrespective of demineralization time. A statistically significant moderate correlation was found between SZmax and ΔZ and SZmax and L after pH cycling. SMH also correlated weakly to moderately with TMR data. CONCLUSIONS SMH and SZmax decreased while ΔZ and L…
author: Alkattan, Rana
language: en_US
keywords: Demineralization, Remineralization, Hardness, Chemical, Composition, Content, Enamel
date published: 2017-05-09
date modified: 2026-07-24T02:42:13Z
provider: IUPUI
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: IUPUI

PropertyValue
property ID: Handle
value: https://hdl.handle.net/1805/12512

PropertyValue
property ID: DOI
value: 10.7912/C2/1639

PropertyValue
property ID: DOI
value: 10.7912/C2DM1R