Iowa State University
Enantioselective epoxidation catalyzed by manganese-substituted human carbonic anhydrase
Abstract
dc:description.abstract<p>Artificial metalloenzymes are an important class of hybrid catalysts for enantioselective, regioselective and chemoselective organic transformations. Despite several limitations associated with this type of hybrid catalysts system and their limited development relative to small molecule catalysts, significant advances have been achieved over the past few decades. This thesis describes the background, applicability of such hybrid catalysts, anchoring strategies and methods involved in the improvement of catalytic activities of artificial metalloenzymes. The generation of a thermostable human carbonic anhydrase mutant, activity determination, generation of an artificial metalloenzyme (manganese-substituted human carbonic anhydrase) and its use as a catalyst for enantioselective epoxidation of olefins is also described.</p>
Degree
thesis:*- Name thesis:degree_name
- Master of Science
- Level thesis:degree_level
- thesis
- Discipline thesis:degree_discipline
- Organic Chemistry
- Department dc:contributor.department
- Department of Chemistry
- Year dc:date.issued
- 2015
Author and committee
dc:creator, dc:contributor.*- Author dc:creator
-
- Weerasekara, Sagarika
- Advisor dc:contributor.advisor
-
- Levi M. Stanley
Rights
- Language dc:language.iso
- en
Identifiers
dc:identifier.*- Identifier
- archive/lib.dr.iastate.edu/etd/14900/
- OAI identifier oai:identifier
- oai:dr.lib.iastate.edu:20.500.12876/29084