{"id":{"repo_id":"hull","oai_identifier":"oai:hull-repository.worktribe.com:4192858"},"canonical_url":"https://search.dev.ndltd.org/etd/hull/oai:hull-repository.worktribe.com:4192858","repository":{"repo_id":"hull","name":"University of Hull","base_url":"https://hull-repository.worktribe.com/oaiprovider"},"display":{"title":"Association of Differing Qatari Genotypes with Vitamin D Metabolites","abstract":"This work aimed to determine the possible association between Qatari genotypes and vitamin-D deficiency and diabetes complications. Through next-generation exome sequencing three major genetic Qatari genotypes were determined, Q1 - Bedouin, Q2 - Persian-South Asian and Q3 - African. The hypothesis was that Qatari genotypes would affect vitamin D and metabolite levels independent of cultural factors, perhaps exacerbated by diabetes.Materials and Methods. Affymetrix 500k SNP arrays determined 398 Qataris genotype (mean age 49.8 years, 56.8% male; type 2 diabetes (T2DM) 220; control 178). LC-MS/MS analysis measured 1,25-dihydroxyvitamin-D (1,25(OH)2D), 25-hydroxyvitamin-D2 (25(OH)D2), 25-hydroxyvitamin-D3 (25(OH)D3), 24,25-dihydroxyvitamin-D (24,25(OH)2D) and 25-hydroxy-3epi-Vitamin-D (3epi25(OH)D). The same study population was used to investigate the association of diabetes and its complications with various genotypes.Results. There was no difference in 25(OH)D levels between genotype groups; however, 1,25(OH)2D was higher for Q2 and 24,25(OH)2D was higher in Q1 compared to the ‘admixed’ group. Additionally, the genotype-based ancestry and type 2 diabetes (T2DM) prevalence: 164 (41.2%) with Q1, 60.4% with T2DM; 149 (37.4%) with Q2, 49.7% with T2DM; 31 (7.8%) with Q3, 61.3% with T2DM; and 54 (13.6%) with “admixed”, 51.9% with T2DM. In patients with diabetes, hypertension (p<0.035) and retinopathy (p<0.016) were greater in Q3.Conclusion. Overall, the study population was vitamin-D deficient, total 25(OH)D was higher in patients with concomitant T2DM, 1,25(OH)2D, 24,25(OH)2D and 3epi25(OH)D were lower in diabetes. Vitamin D levels were not associated with a specific genotype. Q3 was found to have a higher frequency of diabetic retinopathy and hypertension.","abstract_html":"This work aimed to determine the possible association between Qatari genotypes and vitamin-D deficiency and diabetes complications. Through next-generation exome sequencing three major genetic Qatari genotypes were determined, Q1 - Bedouin, Q2 - Persian-South Asian and Q3 - African. The hypothesis was that Qatari genotypes would affect vitamin D and metabolite levels independent of cultural factors, perhaps exacerbated by diabetes.Materials and Methods. Affymetrix 500k SNP arrays determined 398 Qataris genotype (mean age 49.8 years, 56.8% male; type 2 diabetes (T2DM) 220; control 178). LC-MS/MS analysis measured 1,25-dihydroxyvitamin-D (1,25(OH)2D), 25-hydroxyvitamin-D2 (25(OH)D2), 25-hydroxyvitamin-D3 (25(OH)D3), 24,25-dihydroxyvitamin-D (24,25(OH)2D) and 25-hydroxy-3epi-Vitamin-D (3epi25(OH)D). The same study population was used to investigate the association of diabetes and its complications with various genotypes.Results. There was no difference in 25(OH)D levels between genotype groups; however, 1,25(OH)2D was higher for Q2 and 24,25(OH)2D was higher in Q1 compared to the ‘admixed’ group. Additionally, the genotype-based ancestry and type 2 diabetes (T2DM) prevalence: 164 (41.2%) with Q1, 60.4% with T2DM; 149 (37.4%) with Q2, 49.7% with T2DM; 31 (7.8%) with Q3, 61.3% with T2DM; and 54 (13.6%) with “admixed”, 51.9% with T2DM. In patients with diabetes, hypertension (p&lt;0.035) and retinopathy (p&lt;0.016) were greater in Q3.Conclusion. Overall, the study population was vitamin-D deficient, total 25(OH)D was higher in patients with concomitant T2DM, 1,25(OH)2D, 24,25(OH)2D and 3epi25(OH)D were lower in diabetes. Vitamin D levels were not associated with a specific genotype. Q3 was found to have a higher frequency of diabetic retinopathy and hypertension.","abstract_has_math":false,"creators":["Dakroury, Youssra"],"institution":"Hull York Medical School, The University of Hull and The University of York","degree_name":"MSc","degree_level":"Masters","degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2020,"date_issued":"2020","date_published":"2020","updated_at":"2026-07-24T02:33:08Z","subjects":[],"languages":["en"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["oai:hull-repository.worktribe.com:4192858"],"render_values":[{"text":"oai:hull-repository.worktribe.com:4192858","href":null,"code":true}]}]},"links":{"outbound_url":"https://hull-repository.worktribe.com/4192858/1/Thesis","outbound_label":"Repository record","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.sponsor","label":"Sponsor","values":["University of Hull"]},{"key":"dc:creator","label":"Author","values":["Dakroury, Youssra"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2020-11-01"]},{"key":"dc:date.issued","label":"Date","values":["2020"]},{"key":"dc:publisher.institution","label":"Dc Publisher Institution","values":["Hull York Medical School, The University of Hull and The University of York"]},{"key":"dc:relation.isreferencedby","label":"Dc Relation Isreferencedby","values":["https://hull-repository.worktribe.com/output/4192858"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]},{"key":"dc:type.qualificationlevel","label":"Dc Type Qualificationlevel","values":["Masters"]},{"key":"dc:type.qualificationname","label":"Dc Type Qualificationname","values":["MSc"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["oai:hull-repository.worktribe.com:4192858"]},{"key":"dc:identifier.uri","label":"Identifier URI","values":["https://hull-repository.worktribe.com/4192858/1/Thesis"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["This work aimed to determine the possible association between Qatari genotypes and vitamin-D deficiency and diabetes complications. Through next-generation exome sequencing three major genetic Qatari genotypes were determined, Q1 - Bedouin, Q2 - Persian-South Asian and Q3 - African. The hypothesis was that Qatari genotypes would affect vitamin D and metabolite levels independent of cultural factors, perhaps exacerbated by diabetes.Materials and Methods. Affymetrix 500k SNP arrays determined 398 Qataris genotype (mean age 49.8 years, 56.8% male; type 2 diabetes (T2DM) 220; control 178). LC-MS/MS analysis measured 1,25-dihydroxyvitamin-D (1,25(OH)2D), 25-hydroxyvitamin-D2 (25(OH)D2), 25-hydroxyvitamin-D3 (25(OH)D3), 24,25-dihydroxyvitamin-D (24,25(OH)2D) and 25-hydroxy-3epi-Vitamin-D (3epi25(OH)D). The same study population was used to investigate the association of diabetes and its complications with various genotypes.Results. There was no difference in 25(OH)D levels between genotype groups; however, 1,25(OH)2D was higher for Q2 and 24,25(OH)2D was higher in Q1 compared to the ‘admixed’ group. Additionally, the genotype-based ancestry and type 2 diabetes (T2DM) prevalence: 164 (41.2%) with Q1, 60.4% with T2DM; 149 (37.4%) with Q2, 49.7% with T2DM; 31 (7.8%) with Q3, 61.3% with T2DM; and 54 (13.6%) with “admixed”, 51.9% with T2DM. In patients with diabetes, hypertension (p<0.035) and retinopathy (p<0.016) were greater in Q3.Conclusion. Overall, the study population was vitamin-D deficient, total 25(OH)D was higher in patients with concomitant T2DM, 1,25(OH)2D, 24,25(OH)2D and 3epi25(OH)D were lower in diabetes. Vitamin D levels were not associated with a specific genotype. Q3 was found to have a higher frequency of diabetic retinopathy and hypertension."]},{"key":"dc:title","label":"Title","values":["Association of Differing Qatari Genotypes with Vitamin D Metabolites"]}]}],"canonical_facts":{"dc:contributor.sponsor":["University of Hull"],"dc:creator":["Dakroury, Youssra"],"dc:date":["2020-11-01"],"dc:date.issued":["2020"],"dc:description.abstract":["This work aimed to determine the possible association between Qatari genotypes and vitamin-D deficiency and diabetes complications. Through next-generation exome sequencing three major genetic Qatari genotypes were determined, Q1 - Bedouin, Q2 - Persian-South Asian and Q3 - African. The hypothesis was that Qatari genotypes would affect vitamin D and metabolite levels independent of cultural factors, perhaps exacerbated by diabetes.Materials and Methods. Affymetrix 500k SNP arrays determined 398 Qataris genotype (mean age 49.8 years, 56.8% male; type 2 diabetes (T2DM) 220; control 178). LC-MS/MS analysis measured 1,25-dihydroxyvitamin-D (1,25(OH)2D), 25-hydroxyvitamin-D2 (25(OH)D2), 25-hydroxyvitamin-D3 (25(OH)D3), 24,25-dihydroxyvitamin-D (24,25(OH)2D) and 25-hydroxy-3epi-Vitamin-D (3epi25(OH)D). The same study population was used to investigate the association of diabetes and its complications with various genotypes.Results. There was no difference in 25(OH)D levels between genotype groups; however, 1,25(OH)2D was higher for Q2 and 24,25(OH)2D was higher in Q1 compared to the ‘admixed’ group. Additionally, the genotype-based ancestry and type 2 diabetes (T2DM) prevalence: 164 (41.2%) with Q1, 60.4% with T2DM; 149 (37.4%) with Q2, 49.7% with T2DM; 31 (7.8%) with Q3, 61.3% with T2DM; and 54 (13.6%) with “admixed”, 51.9% with T2DM. In patients with diabetes, hypertension (p<0.035) and retinopathy (p<0.016) were greater in Q3.Conclusion. Overall, the study population was vitamin-D deficient, total 25(OH)D was higher in patients with concomitant T2DM, 1,25(OH)2D, 24,25(OH)2D and 3epi25(OH)D were lower in diabetes. Vitamin D levels were not associated with a specific genotype. Q3 was found to have a higher frequency of diabetic retinopathy and hypertension."],"dc:identifier":["oai:hull-repository.worktribe.com:4192858"],"dc:identifier.uri":["https://hull-repository.worktribe.com/4192858/1/Thesis"],"dc:language":["en"],"dc:publisher.institution":["Hull York Medical School, The University of Hull and The University of York"],"dc:relation.isreferencedby":["https://hull-repository.worktribe.com/output/4192858"],"dc:title":["Association of Differing Qatari Genotypes with Vitamin D Metabolites"],"dc:type":["Thesis"],"dc:type.qualificationlevel":["Masters"],"dc:type.qualificationname":["MSc"]},"updated_at":"2026-07-24T02:33:08Z"}