The synthesis of WAY-derivatives to find linker location and a new linker to attach a fluorescence tag for homo- or hetero-dimer of 5-HT receptor ligands

Serotonin action or inaction is known to correlate with depression, obesity and drug addiction. The serotonin receptor has been studied as a possible target for cocaine addiction therapy. Previously, 5-HT 2A receptor antagonist, M100907 and 5-HT 2C receptor agonist, WAY 163909 have been studied as molecules to control behaviors related to addiction. Additionally, serotonin receptor families such as 5-HT 2A and 5-H T2C receptors have been found to exist as dimers and oligomers. The focus of this thesis has been on the synthesis and bioactivity of multivalent ligands of M100907 and WAY 163909 for homo- and hetero dimeric ligands. As an extension of previous research, this study includes development of WAY derivatives, which can be developed for homo- or hetero dimeric ligands. In addition, a new linker for homodimers of M100907 derivatives has been developed. Through this new linker, a fluorescence tag can be attached to the dimeric ligands. This will be used to both probe the activity of receptor dimers as well as visualize them.

Name thesis:degree_name

Master of Science

Level thesis:degree_level

Masters

Discipline thesis:degree_discipline

Chemistry

Grantor

University of Houston

Year dc:date.issued

2014

Author dc:creator

• Kim, Soo Jeong 1984-

Advisor dc:contributor.advisor

• Gilbertson, Scott R.

Committee members dc:contributor.committeemember

• Miljanić, Ognjen Š.
• Coltart, Don M.
• Yang, Ding-Shyue
• Briggs, James M.

• Multivalent ligands
• 5-HT receptor

Statement dc:rights

• The author of this work is the copyright owner. UH Libraries and the Texas Digital Library have their permission to store and provide access to this work. Further transmission, reproduction, or presentation of this work is prohibited except with permission of the author(s).

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/10657/1394

OAI identifier oai:identifier

oai:uh-ir.tdl.org:10657/1394