Aberrant segregation in human populations
type: CreativeWork
description: Three cases of aberrant segregation in humans were considered. The first was a possible case of non-random assortment of chromosomes and meiotic drive. Separating children of fathers of given heterozygous ABO genotypes into sperm classes (classified by the ABO gene received from the father), for children of A1B and A2B fathers a change in association of the sperm type with the sex of the child (which would be determined by the father's sex chromosome received) occurred with advancing father's age. Specifically, the B sperm class was associated with the X chromosome when fathers were old and the Y chromosome when they were young. Mother's age and birth order effects were ruled out by multiple regression. This effect was strikingly non-linear: a fifth order polynomial of father's age was very highly significant (for pooled offspring of A1B and A2B fathers). The sex ratio changed within each sperm class in opposite directions. The segregation frequency of the B sperm class for female offspring increased with father's age (but not mother's age or birth order) and again a fifth order polynomial was very highly significant. The progeny of B0, A2O, and A1O plus A1A2 fathers were not affected. There was a non-linear change in segregation frequency of female offspring of AB mothers as mothers grew older which was not highly significant and may have been due to chance. The second study was on the genetic load of the population in Odate, Japan. Prenatal death was examined with respect to several factors and found to fall into at least three classes: early prenatal death (EPRE), up to four months of gestation; late prenatal death (LPRE), up to nine months; stillbirths, more than nine months. LPRE increased significantly (but non-linearly) with inbreeding but EPRE and stillbirths did not; regressions for LPRE and stillbirths differed significantly. Postnatal death was divided into three classes (which differed in several respects): early postnatal death (less than one month old)…
abstract: Three cases of aberrant segregation in humans were considered. The first was a possible case of non-random assortment of chromosomes and meiotic drive. Separating children of fathers of given heterozygous ABO genotypes into sperm classes (classified by the ABO gene received from the father), for children of A1B and A2B fathers a change in association of the sperm type with the sex of the child (which would be determined by the father's sex chromosome received) occurred with advancing father's age. Specifically, the B sperm class was associated with the X chromosome when fathers were old and the Y chromosome when they were young. Mother's age and birth order effects were ruled out by multiple regression. This effect was strikingly non-linear: a fifth order polynomial of father's age was very highly significant (for pooled offspring of A1B and A2B fathers). The sex ratio changed within each sperm class in opposite directions. The segregation frequency of the B sperm class for female offspring increased with father's age (but not mother's age or birth order) and again a fifth order polynomial was very highly significant. The progeny of B0, A2O, and A1O plus A1A2 fathers were not affected. There was a non-linear change in segregation frequency of female offspring of AB mothers as mothers grew older which was not highly significant and may have been due to chance. The second study was on the genetic load of the population in Odate, Japan. Prenatal death was examined with respect to several factors and found to fall into at least three classes: early prenatal death (EPRE), up to four months of gestation; late prenatal death (LPRE), up to nine months; stillbirths, more than nine months. LPRE increased significantly (but non-linearly) with inbreeding but EPRE and stillbirths did not; regressions for LPRE and stillbirths differed significantly. Postnatal death was divided into three classes (which differed in several respects): early postnatal death (less than one month old)…
author: Grove, John Sinclair
keywords: Human genetics
date published: 2009-09-09
date modified: 2026-07-24T02:28:42Z
provider: University of Hawaii
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: University of Hawaii at Manoa

PropertyValue
property ID: Handle
value: http://hdl.handle.net/10125/11493