{"id":{"repo_id":"greece","oai_identifier":"oai:10442/1753"},"canonical_url":"https://search.dev.ndltd.org/etd/greece/oai:10442/1753","repository":{"repo_id":"greece","name":"Greek National Archive of PhD Theses","base_url":"https://phdtheses.ekt.gr/eadd_oai/request"},"display":{"title":"ΟΙ ΣΥΝΕΠΕΙΕΣ ΤΗΣ ΕΚΦΡΑΣΗΣ ΤΗΣ ΠΡΩΤΕΙΝΗΣ Ρ21 ΓΟΝΙΔΙΑΚΟΥ ΠΡΟΙΟΝΤΟΣ ΤΟΥ ΟΓΚΟΓΟΝΙΔΙΟΥ Η-RAS1 ΚΑΤΑ ΤΗΝ ΚΑΡΚΙΝΟΓΕΝΕΣΗ","abstract":"IN THE PRESENT STUDY WAS ESTABLISHED A MODEL SYSTEM TO DETECT THE PRESENCE OF RAS P21 IN THE SERA OF BALB/C MICE CARRYING TUMOURS INDUCED BY MOUSE CELL-LINE TRANSFORMED BY THE HA-MUSV AND THE PRESENCE OF F-MLUV BY ELISA TEST. THE ELAVATED LEVELS OF RAS P21 WAS EXAMINED IN THE SERA OF CANCER PATIENTS ALSO. ONLY IN 3OUT OF 13 CASES REPRESENTING PATIENTS WITH STOMACH ADENOCARCINOMAS WAS RAS P21WAS DETECTED. ALSO WERE INVESTIGATED MIXED CULTURES OF NORMAL EARLY PASSAGE BALB/C EMBRYO CELLS AND BALB/C 3T3 CELLS TRANSFORMED BY THE HUMAN T24 H-RAS ONCOGENE. THE PRESENCE OF AN EXCESS OF NORMAL CELLS COULD SUPPRESS THE PHENOTYPE OF TRANSFORMED CELLS IN VITRO. A SIMILAR TYPE OF SUPPRESSION BY NORMAL CELLS COULDBE SHOWN IN VIVO IN TUMOURS INDUCED BY BALB/C 3T3 RAS TRANSFORMED CELLS.","abstract_html":"IN THE PRESENT STUDY WAS ESTABLISHED A MODEL SYSTEM TO DETECT THE PRESENCE OF RAS P21 IN THE SERA OF BALB/C MICE CARRYING TUMOURS INDUCED BY MOUSE CELL-LINE TRANSFORMED BY THE HA-MUSV AND THE PRESENCE OF F-MLUV BY ELISA TEST. THE ELAVATED LEVELS OF RAS P21 WAS EXAMINED IN THE SERA OF CANCER PATIENTS ALSO. ONLY IN 3OUT OF 13 CASES REPRESENTING PATIENTS WITH STOMACH ADENOCARCINOMAS WAS RAS P21WAS DETECTED. ALSO WERE INVESTIGATED MIXED CULTURES OF NORMAL EARLY PASSAGE BALB/C EMBRYO CELLS AND BALB/C 3T3 CELLS TRANSFORMED BY THE HUMAN T24 H-RAS ONCOGENE. THE PRESENCE OF AN EXCESS OF NORMAL CELLS COULD SUPPRESS THE PHENOTYPE OF TRANSFORMED CELLS IN VITRO. A SIMILAR TYPE OF SUPPRESSION BY NORMAL CELLS COULDBE SHOWN IN VIVO IN TUMOURS INDUCED BY BALB/C 3T3 RAS TRANSFORMED CELLS.","abstract_has_math":false,"creators":["Kakkanas, Athanasios","Κακκανάς, Αθανάσιος"],"institution":"National and Kapodistrian University of Athens","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":1990,"date_issued":"1990","date_published":"1990","updated_at":"2026-07-24T02:25:05Z","subjects":["Cancer patients","ELISA TEST","FRIEND-MURINE LEUKEMIA VIRUS (F-MLV)","HARREY-MURINE SARCOMA VIRUS (HA-MSV)","MICE BALB/C","MODULATION OF MULTIPLICATION OF CANCER CELLS","ONCOGENE H-RAS1#","PRIMARY EMBRYO BALB/C MICE CELLS CARCINOGENESIS","ΙΟΣ ΤΩΝ ΤΡΩΚΤΙΚΩΝ FRIEND-MLV","ΙΟΣ ΤΩΝ ΤΡΩΚΤΙΚΩΝ HA-MUSV","Καρκινογένεση","Καρκινοπαθείς","ΚΑΤΑΣΤΟΛΗ ΠΟΛΛΑΠΛΑΣΙΑΣΜΟΥ ΚΑΡΚΙΝΙΚΩΝ ΚΥΤΤΑΡΩΝ","ΟΓΚΟΝΙΔΙΟ Η-RAS1","ΠΟΝΤΙΚΙΑ BALB/C","ΠΡΩΤΟΓΕΝΗ ΚΥΤΤΑΡΑ ΕΜΒΡΥΟΥ ΠΟΝΤΙΚΟΥ BALB/C","Φυσικές Επιστήμες","Βιολογία","Natural Sciences","Biological Sciences"],"languages":["gre"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["10.12681/eadd/1753"],"render_values":[{"text":"10.12681/eadd/1753","href":"https://doi.org/10.12681/eadd/1753","code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/10442/hedi/1753","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Kakkanas, Athanasios","Κακκανάς, Αθανάσιος"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["1990"]},{"key":"dc:publisher","label":"Institution","values":["National and Kapodistrian University of Athens","Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ)"]},{"key":"dc:type","label":"Dc Type","values":["PhD Thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Cancer patients","ELISA TEST","FRIEND-MURINE LEUKEMIA VIRUS (F-MLV)","HARREY-MURINE SARCOMA VIRUS (HA-MSV)","MICE BALB/C","MODULATION OF MULTIPLICATION OF CANCER CELLS","ONCOGENE H-RAS1#","PRIMARY EMBRYO BALB/C MICE CELLS CARCINOGENESIS","ΙΟΣ ΤΩΝ ΤΡΩΚΤΙΚΩΝ FRIEND-MLV","ΙΟΣ ΤΩΝ ΤΡΩΚΤΙΚΩΝ HA-MUSV","Καρκινογένεση","Καρκινοπαθείς","ΚΑΤΑΣΤΟΛΗ ΠΟΛΛΑΠΛΑΣΙΑΣΜΟΥ ΚΑΡΚΙΝΙΚΩΝ ΚΥΤΤΑΡΩΝ","ΟΓΚΟΝΙΔΙΟ Η-RAS1","ΠΟΝΤΙΚΙΑ BALB/C","ΠΡΩΤΟΓΕΝΗ ΚΥΤΤΑΡΑ ΕΜΒΡΥΟΥ ΠΟΝΤΙΚΟΥ BALB/C","Φυσικές Επιστήμες","Βιολογία","Natural Sciences","Biological Sciences"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["gre"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["10.12681/eadd/1753","http://hdl.handle.net/10442/hedi/1753"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["IN THE PRESENT STUDY WAS ESTABLISHED A MODEL SYSTEM TO DETECT THE PRESENCE OF RAS P21 IN THE SERA OF BALB/C MICE CARRYING TUMOURS INDUCED BY MOUSE CELL-LINE TRANSFORMED BY THE HA-MUSV AND THE PRESENCE OF F-MLUV BY ELISA TEST. THE ELAVATED LEVELS OF RAS P21 WAS EXAMINED IN THE SERA OF CANCER PATIENTS ALSO. ONLY IN 3OUT OF 13 CASES REPRESENTING PATIENTS WITH STOMACH ADENOCARCINOMAS WAS RAS P21WAS DETECTED. ALSO WERE INVESTIGATED MIXED CULTURES OF NORMAL EARLY PASSAGE BALB/C EMBRYO CELLS AND BALB/C 3T3 CELLS TRANSFORMED BY THE HUMAN T24 H-RAS ONCOGENE. THE PRESENCE OF AN EXCESS OF NORMAL CELLS COULD SUPPRESS THE PHENOTYPE OF TRANSFORMED CELLS IN VITRO. A SIMILAR TYPE OF SUPPRESSION BY NORMAL CELLS COULDBE SHOWN IN VIVO IN TUMOURS INDUCED BY BALB/C 3T3 RAS TRANSFORMED CELLS.","ΣΤΗΝ ΠΑΡΟΥΣΑ ΔΙΔΑΚΤΟΡΙΚΗ ΔΙΑΤΡΙΒΗ ΚΑΘΙΕΡΩΘΗΚΕ ΕΝΑ ΠΕΙΡΑΜΑΤΙΚΟ ΜΟΝΤΕΛΟ-ΣΥΣΤΗΜΑ ΓΙΑ ΝΑ ΑΝΙΧΝΕΥΘΕΙ Η ΠΑΡΟΥΣΙΑ ΤΗΣ ΠΡΩΤΕΙΝΗΣ RASP21 ΣΤΟΝ ΟΡΟ ΤΩΝ ΠΟΝΤΙΚΩΝ BALB/C ΠΟΥ ΑΝΑΠΤΥΣΣΟΥΝ ΟΓΚΟΥΣ ΥΣΤΕΡΑ ΑΠΟ ΤΟΝ ΕΜΒΟΛΙΑΣΜΟ ΤΟΥΣ ΜΕ ΜΕΤΑΣΧΗΜΑΤΙΣΜΕΝΗ ΚΥΤΤΑΡΙΚΗ ΣΕΙΡΑ ΑΠΟ ΤΟΝ ΙΟ HA-MUSV ΚΑΙ ΤΗΝ ΠΑΡΟΥΣΙΑ F-MLUV ΜΕ ΕΝΑ ELISA TEST. ΑΥΞΗΜΕΝΑ ΕΠΙΣΗΣ ΕΠΙΠΕΔΑ ΤΗΣ ΠΡΩΤΕΙΝΗΣ RASP21 ΑΝΑΚΑΛΥΦΘΗΚΑΝ ΣΤΟΝ ΟΡΟ ΤΩΝ ΚΑΡΚΙΝΟΠΑΘΩΝ. ΜΟΝΟ ΣΕ 3 ΤΩΝ 13 ΕΞΕΤΑΖΟΜΕΝΩΝ ΠΕΡΙΠΤΩΣΕΩΝ ΟΡΩΝ ΚΑΡΚΙΝΟΠΑΘΩΝ ΜΕ ΑΔΕΝΟΚΑΡΚΙΝΩΜΑΤΑΣΤΟΜΑΧΟΥ ΑΝΙΧΝΕΥΘΗΚΑΝ ΕΠΙΠΕΔΑ RAS ΠΡΩΤΕΙΝΗΣ Ρ21. ΑΚΟΜΑ ΜΕΛΕΤΗΘΗΚΑΝ ΜΙΚΤΕΣ ΚΑΛΛΙΕΡΓΕΙΕΣ ΦΥΣΙΟΛΟΓΙΚΩΝ ΠΡΩΤΟΓΕΝΩΝ ΕΜΒΡΥΙΚΩΝ ΚΥΤΤΑΡΩΝ BALB/C ΚΑΙ ΚΥΤΤΑΡΩΝ BALB/C ΜΕΤΑΣΧΗΜΑΤΙΣΜΕΝΩΝ ΑΠΟ ΤΟ ΟΓΚΟΝΙΔΙΟ H-RAS1. Η ΠΑΡΟΥΣΙΑ ΜΕΓΑΛΩΝ ΠΛΗΘΥΣΜΩΝ ΤΩΝ ΦΥΣΙΟΛΟΓΙΚΩΝ ΚΥΤΤΑΡΩΝ ΜΠΟΡΟΥΣΕ ΝΑ ΚΑΤΑΣΤΕΙΛΕΙ ΤΟΝ ΚΑΚΟΗΘΗ ΦΑΙΝΟΤΥΠΟ ΤΩΝ ΜΕΤΑΣΧΗΜΑΤΙΣΜΕΝΩΝ ΚΥΤΤΑΡΩΝ IN VITRO. ΠΑΡΟΜΟΙΑ ΚΑΤΑΣΤΟΛΗ ΑΠΟ ΦΥΣΙΟΛΟΓΙΚΑ ΚΥΤΤΑΡΑ ΔΕΙΧΤΗΚΕ IN VIVO ΣΕ ΟΓΚΟΥΣ ΠΟΥ ΠΡΟΚΛΗΘΗΚΑΝ ΣΕ ΠΟΝΤΙΚΙΑ BALB/C ΑΠΟ ΤΑ RAS ΜΕΤΑΣΧΗΜΑΤΙΣΜΕΝΑ ΚΥΤΤΑΡΑ."]},{"key":"dc:title","label":"Title","values":["ΟΙ ΣΥΝΕΠΕΙΕΣ ΤΗΣ ΕΚΦΡΑΣΗΣ ΤΗΣ ΠΡΩΤΕΙΝΗΣ Ρ21 ΓΟΝΙΔΙΑΚΟΥ ΠΡΟΙΟΝΤΟΣ ΤΟΥ ΟΓΚΟΓΟΝΙΔΙΟΥ Η-RAS1 ΚΑΤΑ ΤΗΝ ΚΑΡΚΙΝΟΓΕΝΕΣΗ","THE CONSEQUENCES OF THE EXPRESSION OF P21 PROTEIN GENE PRODUCT OF H-RAS1 ONCOGENE DURING CARCINOGENESIS"]}]}],"canonical_facts":{"dc:creator":["Kakkanas, Athanasios","Κακκανάς, Αθανάσιος"],"dc:date":["1990"],"dc:description":["IN THE PRESENT STUDY WAS ESTABLISHED A MODEL SYSTEM TO DETECT THE PRESENCE OF RAS P21 IN THE SERA OF BALB/C MICE CARRYING TUMOURS INDUCED BY MOUSE CELL-LINE TRANSFORMED BY THE HA-MUSV AND THE PRESENCE OF F-MLUV BY ELISA TEST. THE ELAVATED LEVELS OF RAS P21 WAS EXAMINED IN THE SERA OF CANCER PATIENTS ALSO. ONLY IN 3OUT OF 13 CASES REPRESENTING PATIENTS WITH STOMACH ADENOCARCINOMAS WAS RAS P21WAS DETECTED. ALSO WERE INVESTIGATED MIXED CULTURES OF NORMAL EARLY PASSAGE BALB/C EMBRYO CELLS AND BALB/C 3T3 CELLS TRANSFORMED BY THE HUMAN T24 H-RAS ONCOGENE. THE PRESENCE OF AN EXCESS OF NORMAL CELLS COULD SUPPRESS THE PHENOTYPE OF TRANSFORMED CELLS IN VITRO. A SIMILAR TYPE OF SUPPRESSION BY NORMAL CELLS COULDBE SHOWN IN VIVO IN TUMOURS INDUCED BY BALB/C 3T3 RAS TRANSFORMED CELLS.","ΣΤΗΝ ΠΑΡΟΥΣΑ ΔΙΔΑΚΤΟΡΙΚΗ ΔΙΑΤΡΙΒΗ ΚΑΘΙΕΡΩΘΗΚΕ ΕΝΑ ΠΕΙΡΑΜΑΤΙΚΟ ΜΟΝΤΕΛΟ-ΣΥΣΤΗΜΑ ΓΙΑ ΝΑ ΑΝΙΧΝΕΥΘΕΙ Η ΠΑΡΟΥΣΙΑ ΤΗΣ ΠΡΩΤΕΙΝΗΣ RASP21 ΣΤΟΝ ΟΡΟ ΤΩΝ ΠΟΝΤΙΚΩΝ BALB/C ΠΟΥ ΑΝΑΠΤΥΣΣΟΥΝ ΟΓΚΟΥΣ ΥΣΤΕΡΑ ΑΠΟ ΤΟΝ ΕΜΒΟΛΙΑΣΜΟ ΤΟΥΣ ΜΕ ΜΕΤΑΣΧΗΜΑΤΙΣΜΕΝΗ ΚΥΤΤΑΡΙΚΗ ΣΕΙΡΑ ΑΠΟ ΤΟΝ ΙΟ HA-MUSV ΚΑΙ ΤΗΝ ΠΑΡΟΥΣΙΑ F-MLUV ΜΕ ΕΝΑ ELISA TEST. ΑΥΞΗΜΕΝΑ ΕΠΙΣΗΣ ΕΠΙΠΕΔΑ ΤΗΣ ΠΡΩΤΕΙΝΗΣ RASP21 ΑΝΑΚΑΛΥΦΘΗΚΑΝ ΣΤΟΝ ΟΡΟ ΤΩΝ ΚΑΡΚΙΝΟΠΑΘΩΝ. ΜΟΝΟ ΣΕ 3 ΤΩΝ 13 ΕΞΕΤΑΖΟΜΕΝΩΝ ΠΕΡΙΠΤΩΣΕΩΝ ΟΡΩΝ ΚΑΡΚΙΝΟΠΑΘΩΝ ΜΕ ΑΔΕΝΟΚΑΡΚΙΝΩΜΑΤΑΣΤΟΜΑΧΟΥ ΑΝΙΧΝΕΥΘΗΚΑΝ ΕΠΙΠΕΔΑ RAS ΠΡΩΤΕΙΝΗΣ Ρ21. ΑΚΟΜΑ ΜΕΛΕΤΗΘΗΚΑΝ ΜΙΚΤΕΣ ΚΑΛΛΙΕΡΓΕΙΕΣ ΦΥΣΙΟΛΟΓΙΚΩΝ ΠΡΩΤΟΓΕΝΩΝ ΕΜΒΡΥΙΚΩΝ ΚΥΤΤΑΡΩΝ BALB/C ΚΑΙ ΚΥΤΤΑΡΩΝ BALB/C ΜΕΤΑΣΧΗΜΑΤΙΣΜΕΝΩΝ ΑΠΟ ΤΟ ΟΓΚΟΝΙΔΙΟ H-RAS1. Η ΠΑΡΟΥΣΙΑ ΜΕΓΑΛΩΝ ΠΛΗΘΥΣΜΩΝ ΤΩΝ ΦΥΣΙΟΛΟΓΙΚΩΝ ΚΥΤΤΑΡΩΝ ΜΠΟΡΟΥΣΕ ΝΑ ΚΑΤΑΣΤΕΙΛΕΙ ΤΟΝ ΚΑΚΟΗΘΗ ΦΑΙΝΟΤΥΠΟ ΤΩΝ ΜΕΤΑΣΧΗΜΑΤΙΣΜΕΝΩΝ ΚΥΤΤΑΡΩΝ IN VITRO. ΠΑΡΟΜΟΙΑ ΚΑΤΑΣΤΟΛΗ ΑΠΟ ΦΥΣΙΟΛΟΓΙΚΑ ΚΥΤΤΑΡΑ ΔΕΙΧΤΗΚΕ IN VIVO ΣΕ ΟΓΚΟΥΣ ΠΟΥ ΠΡΟΚΛΗΘΗΚΑΝ ΣΕ ΠΟΝΤΙΚΙΑ BALB/C ΑΠΟ ΤΑ RAS ΜΕΤΑΣΧΗΜΑΤΙΣΜΕΝΑ ΚΥΤΤΑΡΑ."],"dc:identifier":["10.12681/eadd/1753","http://hdl.handle.net/10442/hedi/1753"],"dc:language":["gre"],"dc:publisher":["National and Kapodistrian University of Athens","Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ)"],"dc:subject":["Cancer patients","ELISA TEST","FRIEND-MURINE LEUKEMIA VIRUS (F-MLV)","HARREY-MURINE SARCOMA VIRUS (HA-MSV)","MICE BALB/C","MODULATION OF MULTIPLICATION OF CANCER CELLS","ONCOGENE H-RAS1#","PRIMARY EMBRYO BALB/C MICE CELLS CARCINOGENESIS","ΙΟΣ ΤΩΝ ΤΡΩΚΤΙΚΩΝ FRIEND-MLV","ΙΟΣ ΤΩΝ ΤΡΩΚΤΙΚΩΝ HA-MUSV","Καρκινογένεση","Καρκινοπαθείς","ΚΑΤΑΣΤΟΛΗ ΠΟΛΛΑΠΛΑΣΙΑΣΜΟΥ ΚΑΡΚΙΝΙΚΩΝ ΚΥΤΤΑΡΩΝ","ΟΓΚΟΝΙΔΙΟ Η-RAS1","ΠΟΝΤΙΚΙΑ BALB/C","ΠΡΩΤΟΓΕΝΗ ΚΥΤΤΑΡΑ ΕΜΒΡΥΟΥ ΠΟΝΤΙΚΟΥ BALB/C","Φυσικές Επιστήμες","Βιολογία","Natural Sciences","Biological Sciences"],"dc:title":["ΟΙ ΣΥΝΕΠΕΙΕΣ ΤΗΣ ΕΚΦΡΑΣΗΣ ΤΗΣ ΠΡΩΤΕΙΝΗΣ Ρ21 ΓΟΝΙΔΙΑΚΟΥ ΠΡΟΙΟΝΤΟΣ ΤΟΥ ΟΓΚΟΓΟΝΙΔΙΟΥ Η-RAS1 ΚΑΤΑ ΤΗΝ ΚΑΡΚΙΝΟΓΕΝΕΣΗ","THE CONSEQUENCES OF THE EXPRESSION OF P21 PROTEIN GENE PRODUCT OF H-RAS1 ONCOGENE DURING CARCINOGENESIS"],"dc:type":["PhD Thesis"]},"updated_at":"2026-07-24T02:25:05Z"}