{"id":{"repo_id":"greece","oai_identifier":"oai:10442/1731"},"canonical_url":"https://search.dev.ndltd.org/etd/greece/oai:10442/1731","repository":{"repo_id":"greece","name":"Greek National Archive of PhD Theses","base_url":"https://phdtheses.ekt.gr/eadd_oai/request"},"display":{"title":"Η νυχθημερήσια διακύμανση της TSH σε νεογνά και βρέφη","abstract":"Normal children and adults show a similar pattern of diurnal variation of TSH secretion with lower values at 11.00 h and higher around 23.00 h. The purpose of this study was to investigate the age of appearance of TSH circadian rhythm. In 57 full-term infants 0-6 months old and in 37- premature infants 1-4 weeks old TSH was measured at 10.30, 11.00, 11.30 h and 22.30, 23.00 and 23.30 h. No diurnal rhythm was detected in both premature and full-term infants less than 4 weeks of life. After the first month of life a significant difference between AM and PM values was observed in full-term infants. In infants 1-2 months old mean±SEM AM and PM values were 2.8±0.2 and 3.5±0.4 mU/L respectively (p<.025), in infants 3-4 months old 3.0±0.6 and 4.1±0.8 (p<.01) and in infants 5-6 months old 1:8±0.2 and 2.6±0.3 (p<0.0005). These data clearly indicate that the development of TSH circadian rhythm starts after the first month of life.","abstract_html":"Normal children and adults show a similar pattern of diurnal variation of TSH secretion with lower values at 11.00 h and higher around 23.00 h. The purpose of this study was to investigate the age of appearance of TSH circadian rhythm. In 57 full-term infants 0-6 months old and in 37- premature infants 1-4 weeks old TSH was measured at 10.30, 11.00, 11.30 h and 22.30, 23.00 and 23.30 h. No diurnal rhythm was detected in both premature and full-term infants less than 4 weeks of life. After the first month of life a significant difference between AM and PM values was observed in full-term infants. In infants 1-2 months old mean±SEM AM and PM values were 2.8±0.2 and 3.5±0.4 mU/L respectively (p&lt;.025), in infants 3-4 months old 3.0±0.6 and 4.1±0.8 (p&lt;.01) and in infants 5-6 months old 1:8±0.2 and 2.6±0.3 (p&lt;0.0005). These data clearly indicate that the development of TSH circadian rhythm starts after the first month of life.","abstract_has_math":false,"creators":["Koulouris, Aris","Κουλούρης, Αριστείδης"],"institution":"University of Patras","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":1991,"date_issued":"1991","date_published":"1991","updated_at":"2026-07-24T02:25:05Z","subjects":["Θυρεοειδοτρόπος ορμόνη","Νυχθημερήσια διακύμανση","Circadian rhythm","Thyrotropin","Ιατρική και Επιστήμες Υγείας","Κλινική Ιατρική","Medical and Health Sciences","Clinical Medicine"],"languages":["gre"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["10.12681/eadd/1731"],"render_values":[{"text":"10.12681/eadd/1731","href":"https://doi.org/10.12681/eadd/1731","code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/10442/hedi/1731","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Koulouris, Aris","Κουλούρης, Αριστείδης"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["1991"]},{"key":"dc:publisher","label":"Institution","values":["University of Patras","Πανεπιστήμιο Πατρών"]},{"key":"dc:type","label":"Dc Type","values":["PhD Thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Θυρεοειδοτρόπος ορμόνη","Νυχθημερήσια διακύμανση","Circadian rhythm","Thyrotropin","Ιατρική και Επιστήμες Υγείας","Κλινική Ιατρική","Medical and Health Sciences","Clinical Medicine"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["gre"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["10.12681/eadd/1731","http://hdl.handle.net/10442/hedi/1731"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Normal children and adults show a similar pattern of diurnal variation of TSH secretion with lower values at 11.00 h and higher around 23.00 h. The purpose of this study was to investigate the age of appearance of TSH circadian rhythm. In 57 full-term infants 0-6 months old and in 37- premature infants 1-4 weeks old TSH was measured at 10.30, 11.00, 11.30 h and 22.30, 23.00 and 23.30 h. No diurnal rhythm was detected in both premature and full-term infants less than 4 weeks of life. After the first month of life a significant difference between AM and PM values was observed in full-term infants. In infants 1-2 months old mean±SEM AM and PM values were 2.8±0.2 and 3.5±0.4 mU/L respectively (p<.025), in infants 3-4 months old 3.0±0.6 and 4.1±0.8 (p<.01) and in infants 5-6 months old 1:8±0.2 and 2.6±0.3 (p<0.0005). These data clearly indicate that the development of TSH circadian rhythm starts after the first month of life.","Φυσιολογικά παιδιά και ενήλικες παρουσιάζουν νυχθημερήσια διακύμανση της έκκρισης TSH με χαμηλότερες τιμές στις 11.00 και υψηλότερες γύρω στις 23.00. Σκοπός αυτής της εργασίας ήταν να διερευνήσει την ηλικία εμφάνισης του νυχθημερήσιου ρυθμού της TSH. Σε 57 τελειόμηνα βρέφη ηλικίας 0-6 μηνών και σε 37 πρόωρα 1-4 εβδομάδων μετρήθηκε η TSH στις 10.30, 11.00, 11.30 το πρωί και 22.30, 23.00 και 23.30 το βράδυ. Τόσο στα πρόωρα όσο και στα τελειόμηνα ηλικίας μικρότερης των 4 εβδομάδων ζωής δεν ευρέθη καμία νυχθημερήσια διακύμανση της TSH. Μετά τον πρώτο μήνα ζωής παρατηρήθηκε στα τελειόμηνα βρέφη μια σημαντική διαφορά μεταξύ πρωινών και βραδινών τιμών. Συγκεκριμένα η μέση τιμή της TSH ± SEM σε βρέφη ηλικίας 1-2 μηνών ήταν 2,8±0,2 το πρωί και 3,5±0,4 mU/L το βράδυ (p<0,025), σε βρέφη 3-4 μηνών 3,0±0,6 και 4,1±0,8 (p<0,01) και σε βρέφη - 5-6 μηνών 1,8±0,2 και 2,6±0,3 (p<0,0005). Αυτές οι μετρήσεις δείχνουν καθαρά όπ η ανάπτυξη του νυχθημερήσιου ρυθμού της TSH αναπτύσσεται μετά τον πρώτο μήνα ζωής."]},{"key":"dc:title","label":"Title","values":["Η νυχθημερήσια διακύμανση της TSH σε νεογνά και βρέφη","Development of TSH circadian rhythm in infancy"]}]}],"canonical_facts":{"dc:creator":["Koulouris, Aris","Κουλούρης, Αριστείδης"],"dc:date":["1991"],"dc:description":["Normal children and adults show a similar pattern of diurnal variation of TSH secretion with lower values at 11.00 h and higher around 23.00 h. The purpose of this study was to investigate the age of appearance of TSH circadian rhythm. In 57 full-term infants 0-6 months old and in 37- premature infants 1-4 weeks old TSH was measured at 10.30, 11.00, 11.30 h and 22.30, 23.00 and 23.30 h. No diurnal rhythm was detected in both premature and full-term infants less than 4 weeks of life. After the first month of life a significant difference between AM and PM values was observed in full-term infants. In infants 1-2 months old mean±SEM AM and PM values were 2.8±0.2 and 3.5±0.4 mU/L respectively (p<.025), in infants 3-4 months old 3.0±0.6 and 4.1±0.8 (p<.01) and in infants 5-6 months old 1:8±0.2 and 2.6±0.3 (p<0.0005). These data clearly indicate that the development of TSH circadian rhythm starts after the first month of life.","Φυσιολογικά παιδιά και ενήλικες παρουσιάζουν νυχθημερήσια διακύμανση της έκκρισης TSH με χαμηλότερες τιμές στις 11.00 και υψηλότερες γύρω στις 23.00. Σκοπός αυτής της εργασίας ήταν να διερευνήσει την ηλικία εμφάνισης του νυχθημερήσιου ρυθμού της TSH. Σε 57 τελειόμηνα βρέφη ηλικίας 0-6 μηνών και σε 37 πρόωρα 1-4 εβδομάδων μετρήθηκε η TSH στις 10.30, 11.00, 11.30 το πρωί και 22.30, 23.00 και 23.30 το βράδυ. Τόσο στα πρόωρα όσο και στα τελειόμηνα ηλικίας μικρότερης των 4 εβδομάδων ζωής δεν ευρέθη καμία νυχθημερήσια διακύμανση της TSH. Μετά τον πρώτο μήνα ζωής παρατηρήθηκε στα τελειόμηνα βρέφη μια σημαντική διαφορά μεταξύ πρωινών και βραδινών τιμών. Συγκεκριμένα η μέση τιμή της TSH ± SEM σε βρέφη ηλικίας 1-2 μηνών ήταν 2,8±0,2 το πρωί και 3,5±0,4 mU/L το βράδυ (p<0,025), σε βρέφη 3-4 μηνών 3,0±0,6 και 4,1±0,8 (p<0,01) και σε βρέφη - 5-6 μηνών 1,8±0,2 και 2,6±0,3 (p<0,0005). Αυτές οι μετρήσεις δείχνουν καθαρά όπ η ανάπτυξη του νυχθημερήσιου ρυθμού της TSH αναπτύσσεται μετά τον πρώτο μήνα ζωής."],"dc:identifier":["10.12681/eadd/1731","http://hdl.handle.net/10442/hedi/1731"],"dc:language":["gre"],"dc:publisher":["University of Patras","Πανεπιστήμιο Πατρών"],"dc:subject":["Θυρεοειδοτρόπος ορμόνη","Νυχθημερήσια διακύμανση","Circadian rhythm","Thyrotropin","Ιατρική και Επιστήμες Υγείας","Κλινική Ιατρική","Medical and Health Sciences","Clinical Medicine"],"dc:title":["Η νυχθημερήσια διακύμανση της TSH σε νεογνά και βρέφη","Development of TSH circadian rhythm in infancy"],"dc:type":["PhD Thesis"]},"updated_at":"2026-07-24T02:25:05Z"}