{"id":{"repo_id":"greece","oai_identifier":"oai:10442/1704"},"canonical_url":"https://search.dev.ndltd.org/etd/greece/oai:10442/1704","repository":{"repo_id":"greece","name":"Greek National Archive of PhD Theses","base_url":"https://phdtheses.ekt.gr/eadd_oai/request"},"display":{"title":"Ισοένζυμα γαλακτικής δεϋδρογενάσης και παθολογία του προστάτη","abstract":"Studies have been done on LDH and especially on the isoenzymes on the prostatic tissue, on 85 patients who were hospitalised in the Department of Urology at the University of Ioannina. The study of LDH has been done by the method of electrophoresis. It has been studied the ratio LDH₅/LDH₁ and it was found that 69 patients were suffering from hyperplasia of the prostate, the ratio was <1. In the remaining 16 patients it was found that the ratio LDH₅/LDH₁ <1. Eleven (11) of those, or 12,9% of the tota number had cancer of the prostate after an hystologic examination, while the remaining five (5), or 5,8% of total had different diseases of the prostate but were negative of cancer. We noted that levels of total LDH activity and the activities of LDH II, III, and IV were not consistently altered to a significant degree in malignant compared and to bening prostate glands. The ratio LDH₅/LDH₁ is a “tumor marker” for a early diagnosis of the cancer of the prostate.","abstract_html":"Studies have been done on LDH and especially on the isoenzymes on the prostatic tissue, on 85 patients who were hospitalised in the Department of Urology at the University of Ioannina. The study of LDH has been done by the method of electrophoresis. It has been studied the ratio LDH₅/LDH₁ and it was found that 69 patients were suffering from hyperplasia of the prostate, the ratio was &lt;1. In the remaining 16 patients it was found that the ratio LDH₅/LDH₁ &lt;1. Eleven (11) of those, or 12,9% of the tota number had cancer of the prostate after an hystologic examination, while the remaining five (5), or 5,8% of total had different diseases of the prostate but were negative of cancer. We noted that levels of total LDH activity and the activities of LDH II, III, and IV were not consistently altered to a significant degree in malignant compared and to bening prostate glands. The ratio LDH₅/LDH₁ is a “tumor marker” for a early diagnosis of the cancer of the prostate.","abstract_has_math":false,"creators":["Grammeniatis, Evangelos","Γραμμενιάτης, Ευάγγελος"],"institution":"University of Ioannina","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":1990,"date_issued":"1990","date_published":"1990","updated_at":"2026-07-24T02:25:05Z","subjects":["Η LDH και παθολογία του προστάτη","Ουρολογία","LDH and diseases of prostate","Ιατρική και Επιστήμες Υγείας","Κλινική Ιατρική","Medical and Health Sciences","Clinical Medicine"],"languages":["gre"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["10.12681/eadd/1704"],"render_values":[{"text":"10.12681/eadd/1704","href":"https://doi.org/10.12681/eadd/1704","code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/10442/hedi/1704","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Grammeniatis, Evangelos","Γραμμενιάτης, Ευάγγελος"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["1990"]},{"key":"dc:publisher","label":"Institution","values":["University of Ioannina","Πανεπιστήμιο Ιωαννίνων"]},{"key":"dc:type","label":"Dc Type","values":["PhD Thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Η LDH και παθολογία του προστάτη","Ουρολογία","LDH and diseases of prostate","Ιατρική και Επιστήμες Υγείας","Κλινική Ιατρική","Medical and Health Sciences","Clinical Medicine"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["gre"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["10.12681/eadd/1704","http://hdl.handle.net/10442/hedi/1704"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Studies have been done on LDH and especially on the isoenzymes on the prostatic tissue, on 85 patients who were hospitalised in the Department of Urology at the University of Ioannina. The study of LDH has been done by the method of electrophoresis. It has been studied the ratio LDH₅/LDH₁ and it was found that 69 patients were suffering from hyperplasia of the prostate, the ratio was <1. In the remaining 16 patients it was found that the ratio LDH₅/LDH₁ <1. Eleven (11) of those, or 12,9% of the tota number had cancer of the prostate after an hystologic examination, while the remaining five (5), or 5,8% of total had different diseases of the prostate but were negative of cancer. We noted that levels of total LDH activity and the activities of LDH II, III, and IV were not consistently altered to a significant degree in malignant compared and to bening prostate glands. The ratio LDH₅/LDH₁ is a “tumor marker” for a early diagnosis of the cancer of the prostate.","Μελετήθηκε η γαλακτική δεϋδρογενάση και ειδικά τα ισοένζυμα αυτής στον προστατικό ιστό σε 85 ασθενείς, οι οποίοι νοσηλεύθηκαν στην Ουρολογική Κλινική του Πανεπιστημίου Ιωαννίνων. Η μελέτη της LDH έγινε με την μέθοδο της ηλεκτροφόρησης. Μελετήθηκε ειδικά η σχέση LDH₅/LDH₁ και βρέθηκε ότι σε 69 ασθενείς που έπασχαν από καλοήθη υπερπλασία του προστάτη η σχέση αυτή ήταν <1. Στους υπόλοιπους 16 ασθενείς βρέθηκε ότι LDH₅/LDH₁ >1. Απ' αυτούς οι έντεκα (11) δηλ. ποσοστό 12,9% επί του συνολικού αριθμού ασθενών, είχαν καρκίνο του προστάτη με ιστολογική βεβαίωση, ενώ οι υπόλοιποι 5 δηλ. ποσοστό 5,8% επί του συνολικού αριθμού, είχαν άλλες παθήσεις του προστάτη και ήταν αρνητικοί για κακοήθεια. Διαπιστώθηκε ότι τα επίπεδα της ολικής LDH ενεργότητος και οι ενεργότητες των ισοενζύμων ΙΙ, III, και IV δεν είχαν μεταβληθεί σε σημαντικό βαθμό σε κακοήθεια και σε καλοήθεια. Η σχέση LDH₅/LDH₁ είναι ένας αξιόπιστος \"καρκινικός δείκτης\" για την πρώϊμη διάγνωση του καρκίνου του προστάτη."]},{"key":"dc:title","label":"Title","values":["Ισοένζυμα γαλακτικής δεϋδρογενάσης και παθολογία του προστάτη","LDH isoenzymes and pathology of the prostate"]}]}],"canonical_facts":{"dc:creator":["Grammeniatis, Evangelos","Γραμμενιάτης, Ευάγγελος"],"dc:date":["1990"],"dc:description":["Studies have been done on LDH and especially on the isoenzymes on the prostatic tissue, on 85 patients who were hospitalised in the Department of Urology at the University of Ioannina. The study of LDH has been done by the method of electrophoresis. It has been studied the ratio LDH₅/LDH₁ and it was found that 69 patients were suffering from hyperplasia of the prostate, the ratio was <1. In the remaining 16 patients it was found that the ratio LDH₅/LDH₁ <1. Eleven (11) of those, or 12,9% of the tota number had cancer of the prostate after an hystologic examination, while the remaining five (5), or 5,8% of total had different diseases of the prostate but were negative of cancer. We noted that levels of total LDH activity and the activities of LDH II, III, and IV were not consistently altered to a significant degree in malignant compared and to bening prostate glands. The ratio LDH₅/LDH₁ is a “tumor marker” for a early diagnosis of the cancer of the prostate.","Μελετήθηκε η γαλακτική δεϋδρογενάση και ειδικά τα ισοένζυμα αυτής στον προστατικό ιστό σε 85 ασθενείς, οι οποίοι νοσηλεύθηκαν στην Ουρολογική Κλινική του Πανεπιστημίου Ιωαννίνων. Η μελέτη της LDH έγινε με την μέθοδο της ηλεκτροφόρησης. Μελετήθηκε ειδικά η σχέση LDH₅/LDH₁ και βρέθηκε ότι σε 69 ασθενείς που έπασχαν από καλοήθη υπερπλασία του προστάτη η σχέση αυτή ήταν <1. Στους υπόλοιπους 16 ασθενείς βρέθηκε ότι LDH₅/LDH₁ >1. Απ' αυτούς οι έντεκα (11) δηλ. ποσοστό 12,9% επί του συνολικού αριθμού ασθενών, είχαν καρκίνο του προστάτη με ιστολογική βεβαίωση, ενώ οι υπόλοιποι 5 δηλ. ποσοστό 5,8% επί του συνολικού αριθμού, είχαν άλλες παθήσεις του προστάτη και ήταν αρνητικοί για κακοήθεια. Διαπιστώθηκε ότι τα επίπεδα της ολικής LDH ενεργότητος και οι ενεργότητες των ισοενζύμων ΙΙ, III, και IV δεν είχαν μεταβληθεί σε σημαντικό βαθμό σε κακοήθεια και σε καλοήθεια. Η σχέση LDH₅/LDH₁ είναι ένας αξιόπιστος \"καρκινικός δείκτης\" για την πρώϊμη διάγνωση του καρκίνου του προστάτη."],"dc:identifier":["10.12681/eadd/1704","http://hdl.handle.net/10442/hedi/1704"],"dc:language":["gre"],"dc:publisher":["University of Ioannina","Πανεπιστήμιο Ιωαννίνων"],"dc:subject":["Η LDH και παθολογία του προστάτη","Ουρολογία","LDH and diseases of prostate","Ιατρική και Επιστήμες Υγείας","Κλινική Ιατρική","Medical and Health Sciences","Clinical Medicine"],"dc:title":["Ισοένζυμα γαλακτικής δεϋδρογενάσης και παθολογία του προστάτη","LDH isoenzymes and pathology of the prostate"],"dc:type":["PhD Thesis"]},"updated_at":"2026-07-24T02:25:05Z"}