{"id":{"repo_id":"greece","oai_identifier":"oai:10442/1652"},"canonical_url":"https://search.dev.ndltd.org/etd/greece/oai:10442/1652","repository":{"repo_id":"greece","name":"Greek National Archive of PhD Theses","base_url":"https://phdtheses.ekt.gr/eadd_oai/request"},"display":{"title":"Πειραματικές μελέτες της θερμορύθμισης: Ορμονικές μεταβολές και διακύμανση βασικών μετάλλων κατά την προσαρμογή επίμυων στο θερμό και ψυχρό περιβάλλον","abstract":"285 wistar rats were used for the present cold (4°C) and hot (35-36°C) adaptation study. 76 rats kept in room temperature, 114 were exposed to cold (4°C) and 95 to hot (35-36°C). Animals of all groups were sacrificed in order to estimate thyroid hormone (T₃, T₄, free T₃, free T₄) TSH, ANP levels, as well as concentrations of essential metals (Zn²⁺, Cu²⁺, Ca²⁺, Mg²⁺) in serum, heart and liver tissue. During cold adaptation thyroid hormone levels were significantly increased, but during hot adaptation thyroid hormone levels were significantly decreased. ANP plasma levels were found significantly increased (up to two or three fold or the controls) during exposure to cold. In hot adaptation transient, though significant increase of ANP levels was observed during the first 24 hours of exposure, and a decrease to significantly low concentrations. Plasma ANP levels changes observed during cold and hot adaptation are probably depended on thyroid hormone actions, and cardiac rate acceleration. From the estimation of essential metals were found that Zn²⁺ and Ca²⁺. In both states, heart tissue concentrations were also positively related to ANP plasma levels. From the determination of Cu²⁺ and Mg²⁺ were found that increased concentrations in heart tissue followed by decreased ANP plasma.","abstract_html":"285 wistar rats were used for the present cold (4°C) and hot (35-36°C) adaptation study. 76 rats kept in room temperature, 114 were exposed to cold (4°C) and 95 to hot (35-36°C). Animals of all groups were sacrificed in order to estimate thyroid hormone (T₃, T₄, free T₃, free T₄) TSH, ANP levels, as well as concentrations of essential metals (Zn²⁺, Cu²⁺, Ca²⁺, Mg²⁺) in serum, heart and liver tissue. During cold adaptation thyroid hormone levels were significantly increased, but during hot adaptation thyroid hormone levels were significantly decreased. ANP plasma levels were found significantly increased (up to two or three fold or the controls) during exposure to cold. In hot adaptation transient, though significant increase of ANP levels was observed during the first 24 hours of exposure, and a decrease to significantly low concentrations. Plasma ANP levels changes observed during cold and hot adaptation are probably depended on thyroid hormone actions, and cardiac rate acceleration. From the estimation of essential metals were found that Zn²⁺ and Ca²⁺. In both states, heart tissue concentrations were also positively related to ANP plasma levels. From the determination of Cu²⁺ and Mg²⁺ were found that increased concentrations in heart tissue followed by decreased ANP plasma.","abstract_has_math":false,"creators":["Vezyraki, Patrona","Βεζυράκη-Αγγελίδη, Πατρώνα"],"institution":"University of Ioannina","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":1991,"date_issued":"1991","date_published":"1991","updated_at":"2026-07-24T02:25:02Z","subjects":["ΑΝΡ (ΑΤΡΙΟ-ΝΑΤΡΙΟΥΡΗΤΙΚΟ ΠΕΠΤΙΔΙΟ)","Ασβέστιο","Θερμο-προσαρμογή","Θερμορύθμιση","Θυρεοειδικές ορμόνες","Μαγνήσιο","Χαλκός ( Cu )","Ψευδάργυρος (Zn)","Ψυχρο-προσαρμογή","ANP (Atria-Natriuretic-Peptide)","Calcium","Cold-adaptation","Copper ( Cu )","Hot-adaptation","Magnesium","Thermoregulation","Thyroid hormones","Zink","Ιατρική και Επιστήμες Υγείας","Βασική Ιατρική","Κλινική Ιατρική","Medical and Health Sciences","Basic Medicine","Clinical Medicine"],"languages":["gre"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["10.12681/eadd/1652"],"render_values":[{"text":"10.12681/eadd/1652","href":"https://doi.org/10.12681/eadd/1652","code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/10442/hedi/1652","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Vezyraki, Patrona","Βεζυράκη-Αγγελίδη, Πατρώνα"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["1991"]},{"key":"dc:publisher","label":"Institution","values":["University of Ioannina","Πανεπιστήμιο Ιωαννίνων"]},{"key":"dc:type","label":"Dc Type","values":["PhD Thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["ΑΝΡ (ΑΤΡΙΟ-ΝΑΤΡΙΟΥΡΗΤΙΚΟ ΠΕΠΤΙΔΙΟ)","Ασβέστιο","Θερμο-προσαρμογή","Θερμορύθμιση","Θυρεοειδικές ορμόνες","Μαγνήσιο","Χαλκός ( Cu )","Ψευδάργυρος (Zn)","Ψυχρο-προσαρμογή","ANP (Atria-Natriuretic-Peptide)","Calcium","Cold-adaptation","Copper ( Cu )","Hot-adaptation","Magnesium","Thermoregulation","Thyroid hormones","Zink","Ιατρική και Επιστήμες Υγείας","Βασική Ιατρική","Κλινική Ιατρική","Medical and Health Sciences","Basic Medicine","Clinical Medicine"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["gre"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["10.12681/eadd/1652","http://hdl.handle.net/10442/hedi/1652"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["285 wistar rats were used for the present cold (4°C) and hot (35-36°C) adaptation study. 76 rats kept in room temperature, 114 were exposed to cold (4°C) and 95 to hot (35-36°C). Animals of all groups were sacrificed in order to estimate thyroid hormone (T₃, T₄, free T₃, free T₄) TSH, ANP levels, as well as concentrations of essential metals (Zn²⁺, Cu²⁺, Ca²⁺, Mg²⁺) in serum, heart and liver tissue. During cold adaptation thyroid hormone levels were significantly increased, but during hot adaptation thyroid hormone levels were significantly decreased. ANP plasma levels were found significantly increased (up to two or three fold or the controls) during exposure to cold. In hot adaptation transient, though significant increase of ANP levels was observed during the first 24 hours of exposure, and a decrease to significantly low concentrations. Plasma ANP levels changes observed during cold and hot adaptation are probably depended on thyroid hormone actions, and cardiac rate acceleration. From the estimation of essential metals were found that Zn²⁺ and Ca²⁺. In both states, heart tissue concentrations were also positively related to ANP plasma levels. From the determination of Cu²⁺ and Mg²⁺ were found that increased concentrations in heart tissue followed by decreased ANP plasma.","Για την πολυπαραγοντική αυτή μελέτη κατά την προσαρμογή στο ψυχρό και θερμό χρησιμοποιήθηκαν 285 επίμυες, 76 επίμυες παρέμειναν σε φυσιολογικές συνθήκες, 114 εκτέθηκαν στο ψυχρό και 95 εκτέθηκαν στο θερμό. Προσδιοριστήκαν οι θυρεοειδής ορμόνες (T₃, T₄, free T₃, free T₄) TSH, ANP και τα βασικά μέταλλα (Zn²⁺, Cu²⁺, Ca²⁺, Mg²⁺) στον ορό, καρδιά, και ήπαρ. Κατά την έκθεση στο ψυχρό παρατηρήθηκε επίταση της θυρεοειδικής λειτουργίας ενώ κατά την προσαρμογή στο θερμό παρατηρήθηκε μείωση της θυρεοειδικής λειτουργίας. Από τον προσδιορισμό του ANP (Ατριο-Νατριουρητικό Πεπτίδιο) παρατηρήθηκε ότι κατά την προσαρμογή στο ψυχρό τα επίπεδα του ANP αυξάνονται σε συγκεντρώσεις διπλάσιες-τριπλάσιες σε όλη την διάρκεια της έκθεσης. Κατά την προσαρμογή στο θερμό εκτός της αρχικής αύξησης, ακολούθησε καθοδική πορεία της συγκέντρωσης του ANP. Οι μεταβολές αυτές μπορεί να οφείλονται τόσο στην επίδραση των θυρεοειδικών ορμονών όσο και της αύξησης του καρδιακού ρυθμού. Από τον προσδιορισμό των βασικών μετάλλων παρατηρήθηκε ότι όσον αφορά τον Zn²⁺ και το Ca²⁺ πιθανώς η μετακίνηση του μυοκαρδίου των κόλπων. Όσον αφορά τον Cu²⁺ και Mg²⁺ πιθανώς η αύξηση τους στην καρδιά να ασκεί κατασταλτική επιδράσει στην απελευθέρωση του ANP στο πλάσμα."]},{"key":"dc:title","label":"Title","values":["Πειραματικές μελέτες της θερμορύθμισης: Ορμονικές μεταβολές και διακύμανση βασικών μετάλλων κατά την προσαρμογή επίμυων στο θερμό και ψυχρό περιβάλλον","Experimental studies in thermoregulation: Hormone alterations and the fluctuations of essential metals during codid and not adaptation of the wistar rats"]}]}],"canonical_facts":{"dc:creator":["Vezyraki, Patrona","Βεζυράκη-Αγγελίδη, Πατρώνα"],"dc:date":["1991"],"dc:description":["285 wistar rats were used for the present cold (4°C) and hot (35-36°C) adaptation study. 76 rats kept in room temperature, 114 were exposed to cold (4°C) and 95 to hot (35-36°C). Animals of all groups were sacrificed in order to estimate thyroid hormone (T₃, T₄, free T₃, free T₄) TSH, ANP levels, as well as concentrations of essential metals (Zn²⁺, Cu²⁺, Ca²⁺, Mg²⁺) in serum, heart and liver tissue. During cold adaptation thyroid hormone levels were significantly increased, but during hot adaptation thyroid hormone levels were significantly decreased. ANP plasma levels were found significantly increased (up to two or three fold or the controls) during exposure to cold. In hot adaptation transient, though significant increase of ANP levels was observed during the first 24 hours of exposure, and a decrease to significantly low concentrations. Plasma ANP levels changes observed during cold and hot adaptation are probably depended on thyroid hormone actions, and cardiac rate acceleration. From the estimation of essential metals were found that Zn²⁺ and Ca²⁺. In both states, heart tissue concentrations were also positively related to ANP plasma levels. From the determination of Cu²⁺ and Mg²⁺ were found that increased concentrations in heart tissue followed by decreased ANP plasma.","Για την πολυπαραγοντική αυτή μελέτη κατά την προσαρμογή στο ψυχρό και θερμό χρησιμοποιήθηκαν 285 επίμυες, 76 επίμυες παρέμειναν σε φυσιολογικές συνθήκες, 114 εκτέθηκαν στο ψυχρό και 95 εκτέθηκαν στο θερμό. Προσδιοριστήκαν οι θυρεοειδής ορμόνες (T₃, T₄, free T₃, free T₄) TSH, ANP και τα βασικά μέταλλα (Zn²⁺, Cu²⁺, Ca²⁺, Mg²⁺) στον ορό, καρδιά, και ήπαρ. Κατά την έκθεση στο ψυχρό παρατηρήθηκε επίταση της θυρεοειδικής λειτουργίας ενώ κατά την προσαρμογή στο θερμό παρατηρήθηκε μείωση της θυρεοειδικής λειτουργίας. Από τον προσδιορισμό του ANP (Ατριο-Νατριουρητικό Πεπτίδιο) παρατηρήθηκε ότι κατά την προσαρμογή στο ψυχρό τα επίπεδα του ANP αυξάνονται σε συγκεντρώσεις διπλάσιες-τριπλάσιες σε όλη την διάρκεια της έκθεσης. Κατά την προσαρμογή στο θερμό εκτός της αρχικής αύξησης, ακολούθησε καθοδική πορεία της συγκέντρωσης του ANP. Οι μεταβολές αυτές μπορεί να οφείλονται τόσο στην επίδραση των θυρεοειδικών ορμονών όσο και της αύξησης του καρδιακού ρυθμού. Από τον προσδιορισμό των βασικών μετάλλων παρατηρήθηκε ότι όσον αφορά τον Zn²⁺ και το Ca²⁺ πιθανώς η μετακίνηση του μυοκαρδίου των κόλπων. Όσον αφορά τον Cu²⁺ και Mg²⁺ πιθανώς η αύξηση τους στην καρδιά να ασκεί κατασταλτική επιδράσει στην απελευθέρωση του ANP στο πλάσμα."],"dc:identifier":["10.12681/eadd/1652","http://hdl.handle.net/10442/hedi/1652"],"dc:language":["gre"],"dc:publisher":["University of Ioannina","Πανεπιστήμιο Ιωαννίνων"],"dc:subject":["ΑΝΡ (ΑΤΡΙΟ-ΝΑΤΡΙΟΥΡΗΤΙΚΟ ΠΕΠΤΙΔΙΟ)","Ασβέστιο","Θερμο-προσαρμογή","Θερμορύθμιση","Θυρεοειδικές ορμόνες","Μαγνήσιο","Χαλκός ( Cu )","Ψευδάργυρος (Zn)","Ψυχρο-προσαρμογή","ANP (Atria-Natriuretic-Peptide)","Calcium","Cold-adaptation","Copper ( Cu )","Hot-adaptation","Magnesium","Thermoregulation","Thyroid hormones","Zink","Ιατρική και Επιστήμες Υγείας","Βασική Ιατρική","Κλινική Ιατρική","Medical and Health Sciences","Basic Medicine","Clinical Medicine"],"dc:title":["Πειραματικές μελέτες της θερμορύθμισης: Ορμονικές μεταβολές και διακύμανση βασικών μετάλλων κατά την προσαρμογή επίμυων στο θερμό και ψυχρό περιβάλλον","Experimental studies in thermoregulation: Hormone alterations and the fluctuations of essential metals during codid and not adaptation of the wistar rats"],"dc:type":["PhD Thesis"]},"updated_at":"2026-07-24T02:25:02Z"}