{"id":{"repo_id":"greece","oai_identifier":"oai:10442/1502"},"canonical_url":"https://search.dev.ndltd.org/etd/greece/oai:10442/1502","repository":{"repo_id":"greece","name":"Greek National Archive of PhD Theses","base_url":"https://phdtheses.ekt.gr/eadd_oai/request"},"display":{"title":"ΜΕΛΕΤΗ ΤΗΣ ΔΙΑΜΟΡΦΩΣΗΣ ΚΑΙ ΤΗΣ ΜΟΡΙΑΚΗΣ ΔΥΝΑΜΙΚΗΣ ΤΩΝ ΕΓΚΕΦΑΛΙΝΩΝ ΜΕ ΦΑΣΜΑΤΟΣΚΟΠΙΑ ΠΥΡΗΝΙΚΟΥ ΜΑΓΝΗΤΙΚΟΥ ΣΥΝΤΟΝΙΣΜΟΥ (17Ο-NMR) ΚΑΙ ΥΠΕΡΥΘΡΟΥ...","abstract":"IN THIS STUDY THE RESULTS OF 17O-NMR STUDIES OF LEU-ENKEPHALIN SELECTIVELY ENRICHED IN 17O IN POSITIONS GLY-2, GLY-3 AND THE TERMINAL CARBOXYL GROUP ARE REPORTED. FROM STUDIES IN AQUEOUS SOLUTIONS AND IN CH3CH/DMSO (4:1) MIXTURES, IN SEVERAL PH AND TEMPERATURE VALUES IT IS CONCLUDED THAT BOTH PEPTIDE OXYGENS ARE NOT INTRAMOLECULARLY HYDROGEN BONDED AND IN WATER EXIST MAINLY IN MONOHYDRATED FORM. THUS A B-TURN STRUCTURE SHOULD BE EXCLUDED. IT WAS ALSO DEMONSTRATED THAT IN CH3CN/DMSO MIXTURE, LEU-ENKEPHALIN EXISTS AT PH 5,6 NOT IN THE ZWITTERIONIC FORM BUT IN THE NEUTRAL. THIS WAS CONFIRMED BY IR-FT STUDIES. IN ORDER TO STUDY SIDE- CHAIN CONFORMATION OF TYROSINE CONTAINING PEPTIDES, SEVERAL 17O SELECTIVELY ENRICHED MODEL COMPOUNDS WERE PREPARED. 17O-NMR SPECTROSCOPY WAS PROVED TO BE A VALUABLE TOOL FOR THE INVESTIGATION OF THE IONIZATION STATE OF THE PHENOL GROUP. IR-FT STUDIES REVEALED THAT THE IN PLANE C-O-H BENDING FREQUENCIES ARE VERY SENSITIVE IN HYDROGEN BONDING INTERACTIONS AND DISCRETE HYDROGEN BONDING SPECIES COULD BE IDENTIFIED. IR-FT STUDIES OF LEU-ENKEPHALIN IN H2O HAVE SHOWN THAT TYROSINE PHENOL GROUP IS DIHYDRATED AND NOT INTRAMOLECULARLY HYDROGEN BONDED.","abstract_html":"IN THIS STUDY THE RESULTS OF 17O-NMR STUDIES OF LEU-ENKEPHALIN SELECTIVELY ENRICHED IN 17O IN POSITIONS GLY-2, GLY-3 AND THE TERMINAL CARBOXYL GROUP ARE REPORTED. FROM STUDIES IN AQUEOUS SOLUTIONS AND IN CH3CH/DMSO (4:1) MIXTURES, IN SEVERAL PH AND TEMPERATURE VALUES IT IS CONCLUDED THAT BOTH PEPTIDE OXYGENS ARE NOT INTRAMOLECULARLY HYDROGEN BONDED AND IN WATER EXIST MAINLY IN MONOHYDRATED FORM. THUS A B-TURN STRUCTURE SHOULD BE EXCLUDED. IT WAS ALSO DEMONSTRATED THAT IN CH3CN/DMSO MIXTURE, LEU-ENKEPHALIN EXISTS AT PH 5,6 NOT IN THE ZWITTERIONIC FORM BUT IN THE NEUTRAL. THIS WAS CONFIRMED BY IR-FT STUDIES. IN ORDER TO STUDY SIDE- CHAIN CONFORMATION OF TYROSINE CONTAINING PEPTIDES, SEVERAL 17O SELECTIVELY ENRICHED MODEL COMPOUNDS WERE PREPARED. 17O-NMR SPECTROSCOPY WAS PROVED TO BE A VALUABLE TOOL FOR THE INVESTIGATION OF THE IONIZATION STATE OF THE PHENOL GROUP. IR-FT STUDIES REVEALED THAT THE IN PLANE C-O-H BENDING FREQUENCIES ARE VERY SENSITIVE IN HYDROGEN BONDING INTERACTIONS AND DISCRETE HYDROGEN BONDING SPECIES COULD BE IDENTIFIED. IR-FT STUDIES OF LEU-ENKEPHALIN IN H2O HAVE SHOWN THAT TYROSINE PHENOL GROUP IS DIHYDRATED AND NOT INTRAMOLECULARLY HYDROGEN BONDED.","abstract_has_math":false,"creators":["Μπιρλιράκης, Νικόλαος"],"institution":"Πανεπιστήμιο Ιωαννίνων","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":1990,"date_issued":"1990","date_published":"1990","updated_at":"2026-07-24T02:24:59Z","subjects":["CONFORMATION OF PEPTIDES","ENKEPHALINS","HYDRATION OF PEPTIDES","Hydrogen bonding","Infrared spectroscopy","Nuclear magnetic resonance spectroscopy","Peptides synthesis","SELECTIVE ISOTOPIC ENRICHEMENT","Δεσμοί υδρογόνου","ΔΙΑΜΟΡΦΩΣΗ ΤΩΝ ΠΕΠΤΙΔΙΩΝ","ΕΓΚΕΦΑΛΙΝΕΣ","ΕΚΛΕΚΤΙΚΟΣ ΙΣΟΤΟΠΙΚΟΣ ΕΜΠΛΟΥΤΙΣΜΟΣ","ΕΝΥΔΑΤΩΣΗ ΤΩΝ ΠΕΠΤΙΔΙΩΝ","Πεπτιδική σύνθεση","Φασματοσκοπία πυρηνικού μαγνητικού συντονισμού","Φασματοσκοπία υπερύθρου","Φυσικές Επιστήμες","Natural Sciences","Χημεία","Chemical Sciences"],"languages":["gre"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["10.12681/eadd/1502"],"render_values":[{"text":"10.12681/eadd/1502","href":"https://doi.org/10.12681/eadd/1502","code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/10442/hedi/1502","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Μπιρλιράκης, Νικόλαος"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["1990"]},{"key":"dc:publisher","label":"Institution","values":["Πανεπιστήμιο Ιωαννίνων","University of Ioannina"]},{"key":"dc:type","label":"Dc Type","values":["PhD Thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["CONFORMATION OF PEPTIDES","ENKEPHALINS","HYDRATION OF PEPTIDES","Hydrogen bonding","Infrared spectroscopy","Nuclear magnetic resonance spectroscopy","Peptides synthesis","SELECTIVE ISOTOPIC ENRICHEMENT","Δεσμοί υδρογόνου","ΔΙΑΜΟΡΦΩΣΗ ΤΩΝ ΠΕΠΤΙΔΙΩΝ","ΕΓΚΕΦΑΛΙΝΕΣ","ΕΚΛΕΚΤΙΚΟΣ ΙΣΟΤΟΠΙΚΟΣ ΕΜΠΛΟΥΤΙΣΜΟΣ","ΕΝΥΔΑΤΩΣΗ ΤΩΝ ΠΕΠΤΙΔΙΩΝ","Πεπτιδική σύνθεση","Φασματοσκοπία πυρηνικού μαγνητικού συντονισμού","Φασματοσκοπία υπερύθρου","Φυσικές Επιστήμες","Natural Sciences","Χημεία","Chemical Sciences"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["gre"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["10.12681/eadd/1502","http://hdl.handle.net/10442/hedi/1502"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["IN THIS STUDY THE RESULTS OF 17O-NMR STUDIES OF LEU-ENKEPHALIN SELECTIVELY ENRICHED IN 17O IN POSITIONS GLY-2, GLY-3 AND THE TERMINAL CARBOXYL GROUP ARE REPORTED. FROM STUDIES IN AQUEOUS SOLUTIONS AND IN CH3CH/DMSO (4:1) MIXTURES, IN SEVERAL PH AND TEMPERATURE VALUES IT IS CONCLUDED THAT BOTH PEPTIDE OXYGENS ARE NOT INTRAMOLECULARLY HYDROGEN BONDED AND IN WATER EXIST MAINLY IN MONOHYDRATED FORM. THUS A B-TURN STRUCTURE SHOULD BE EXCLUDED. IT WAS ALSO DEMONSTRATED THAT IN CH3CN/DMSO MIXTURE, LEU-ENKEPHALIN EXISTS AT PH 5,6 NOT IN THE ZWITTERIONIC FORM BUT IN THE NEUTRAL. THIS WAS CONFIRMED BY IR-FT STUDIES. IN ORDER TO STUDY SIDE- CHAIN CONFORMATION OF TYROSINE CONTAINING PEPTIDES, SEVERAL 17O SELECTIVELY ENRICHED MODEL COMPOUNDS WERE PREPARED. 17O-NMR SPECTROSCOPY WAS PROVED TO BE A VALUABLE TOOL FOR THE INVESTIGATION OF THE IONIZATION STATE OF THE PHENOL GROUP. IR-FT STUDIES REVEALED THAT THE IN PLANE C-O-H BENDING FREQUENCIES ARE VERY SENSITIVE IN HYDROGEN BONDING INTERACTIONS AND DISCRETE HYDROGEN BONDING SPECIES COULD BE IDENTIFIED. IR-FT STUDIES OF LEU-ENKEPHALIN IN H2O HAVE SHOWN THAT TYROSINE PHENOL GROUP IS DIHYDRATED AND NOT INTRAMOLECULARLY HYDROGEN BONDED.","ΣΤΗΝ ΠΑΡΟΥΣΑ ΕΡΓΑΣΙΑ ΠΑΡΑΤΙΘΕΝΤΑΙ ΤΑ ΑΠΟΤΕΛΕΣΜΑΤΑ ΤΩΝ ΜΕΛΕΤΩΝ ΜΕ ΦΑΣΜΑΤΟΣΚΟΠΙΑ 17Ο-NMR, ΤΩΝ ΕΚΛΕΚΤΙΚΑ ΕΜΠΛΟΥΤΙΣΜΕΝΩΝ ΜΕ 17Ο ΕΓΚΕΦΑΛΙΝΩΝ ΣΤΙΣ ΘΕΣΕΙΣ GLY-2, GLY-3 ΚΑΙ ΣΤΟ ΚΑΡΒΟΞΥΛΙΟ. ΜΕΛΕΤΕΣ ΣΕ ΥΔΑΤΙΚΟ ΔΙΑΛΥΜΑ ΚΑΙ ΣΕ ΜΙΓΜΑ CH3CN/DMSO (4:1), ΣΕ ΔΙΑΦΟΡΕΣ ΘΕΡΜΟΚΡΑΣΙΕΣ ΚΑΙ ΡΗ, ΕΔΕΙΞΑΝ ΟΤΙ ΚΑΙ ΤΑ ΔΥΟ ΠΕΠΤΙΔΙΑ ΟΞΥΓΟΝΑ ΔΕΝ ΣΥΜΜΕΤΕΧΟΥΝ ΣΕ ΕΝΔΟΜΟΡΙΑΚΟ ΔΕΣΜΟ ΥΔΡΟΓΟΝΟΥ ΚΑΙ ΣΤΟ ΝΕΡΟ ΥΦΙΣΤΑΝΤΑΙ ΚΥΡΙΩΣ ΣΤΗΝ ΜΟΝΟΕΝΥΔΑΤΩΜΕΝΗ ΤΟΥΣ ΜΟΡΦΗ. ΕΠΟΜΕΝΩΣ ΘΑ ΠΡΕΠΕΙ ΝΑ ΑΠΟΚΛΕΙΣΘΕΙ ΤΟ ΕΝΔΕΧΟΜΕΝΟ ΝΑ ΣΧΗΜΑΤΙΖΕΙ ΤΟ ΜΟΡΙΟ ΜΙΑ Β- ΣΤΡΟΦΗ. ΕΠΙΣΗΣ ΑΠΟΔΕΙΧΘΗΚΕ ΟΤΙ ΣΕ ΜΙΓΜΑ CH3CN/DMSO ΚΑΙ ΣΕ ΡΗ 5,6 Η LEU-ΕΓΚΕΦΑΛΙΝΗ ΥΦΙΣΤΑΤΑΙ ΣΤΗΝ ΟΥΔΕΤΕΡΗ ΜΟΡΦΗ ΚΑΙ ΟΧΙ ΣΤΗ ΔΙΠΟΛΙΚΗ. ΤΟ ΣΥΜΠΕΡΑΣΜΑ ΑΥΤΟ ΕΠΙΒΕΒΑΙΩΘΗΚΕ ΚΑΙ ΜΕ ΜΕΛΕΤΕΣ ΜΕ ΦΑΣΜΑΤΟΣΚΟΠΙΑ ΥΠΕΡΥΘΡΟΥ.ΓΙΑ ΤΗΝ ΠΡΑΓΜΑΤΟΠΟΙΗΣΗ ΜΕΛΕΤΩΝ ΕΠΙ ΤΗΣ ΠΑΡΑΠΛΕΥΡΗΣ ΑΛΥΣΙΔΑΣ ΠΕΠΤΙΔΙΩΝ ΠΟΥ ΠΕΡΙΕΧΟΥΝ ΤΥΡΟΣΙΝΗ: ΕΓΙΝΕ Η ΣΥΝΘΕΣΗ ΠΡΟΤΥΠΩΝ ΕΝΩΣΕΩΝ, ΕΚΛΕΚΤΙΚΑ ΕΜΠΛΟΥΤΙΣΜΕΝΩΝ ΜΕ 17Ο. Η ΦΑΣΜΑΤΟΣΚΟΠΙΑ 17Ο-NMR ΑΠΟΔΕΙΧΘΗΚΕ ΟΤΙ ΕΙΝΑΙ ΜΙΑ ΜΕΘΟΔΟΣ ΕΥΑΙΣΘΗΤΗ ΚΑΙ ΑΚΡΙΒΗΣ ΓΙΑ ΤΗΝ ΔΙΕΡΕΥΝΗΣΗ ΤΗΣ ΚΑΤΑΣΤΑΣΗΣ ΙΟΝΙΣΜΟΥ ΦΑΙΝΟΛΙΚΟΥ ΥΔΡΟΞΥΛΙΟΥ. ΜΕΛΕΤΕΣ IR-FT ΕΔΕΙΞΑΝ ΟΤΙ ΟΙ ΕΝΤΟΣ ΕΠΙΠΕΔΟΥ ΑΠΟΡΡΟΦΗΣΕΙΣ C-O-H ΕΙΝΑΙ ΕΥΑΙΣΘΗΤΕΣ ΣΕ ΑΛΛΗΛΕΠΙΔΡΑΣΕΙΣ ΔΕΣΜΩΝ ΥΔΡΟΓΟΝΟΥ. ΜΕΛΕΤΕΣ IR-FT ΤΗΣ LEU-ΕΓΚΕΦΑΛΙΝΕΣ ΣΕ Η2Ο ΕΔΕΙΞΑΝ ΟΤΙ ΤΟ ΦΑΙΝΟΛΙΚΟ ΥΔΡΟΞΥΛΙΟ ΤΗΣ TYR ΕΙΝΑΙ ΔΙΣΕΝΥΔΑΤΩΜΕΝΟ ΚΑΙ ΔΕΝ ΣΥΜΜΕΤΕΧΕΙ ΣΕ ΕΝΔΟΜΟΡΙΑΚΟ ΔΕΣΜΟ ΥΔΡΟΓΟΝΟΥ."]},{"key":"dc:title","label":"Title","values":["ΜΕΛΕΤΗ ΤΗΣ ΔΙΑΜΟΡΦΩΣΗΣ ΚΑΙ ΤΗΣ ΜΟΡΙΑΚΗΣ ΔΥΝΑΜΙΚΗΣ ΤΩΝ ΕΓΚΕΦΑΛΙΝΩΝ ΜΕ ΦΑΣΜΑΤΟΣΚΟΠΙΑ ΠΥΡΗΝΙΚΟΥ ΜΑΓΝΗΤΙΚΟΥ ΣΥΝΤΟΝΙΣΜΟΥ (17Ο-NMR) ΚΑΙ ΥΠΕΡΥΘΡΟΥ...","STUDY OF THE CONFORMATION AND DYNAMIC PROPERTIES OF ENKEPHALINS WITH 17O-NMR AND IR-FT SPECTROSCOPIES CONTRIBUTION TO THE SYNTHESIS OF ISOTOPICALLY LABELLED ANALOGS"]}]}],"canonical_facts":{"dc:creator":["Μπιρλιράκης, Νικόλαος"],"dc:date":["1990"],"dc:description":["IN THIS STUDY THE RESULTS OF 17O-NMR STUDIES OF LEU-ENKEPHALIN SELECTIVELY ENRICHED IN 17O IN POSITIONS GLY-2, GLY-3 AND THE TERMINAL CARBOXYL GROUP ARE REPORTED. FROM STUDIES IN AQUEOUS SOLUTIONS AND IN CH3CH/DMSO (4:1) MIXTURES, IN SEVERAL PH AND TEMPERATURE VALUES IT IS CONCLUDED THAT BOTH PEPTIDE OXYGENS ARE NOT INTRAMOLECULARLY HYDROGEN BONDED AND IN WATER EXIST MAINLY IN MONOHYDRATED FORM. THUS A B-TURN STRUCTURE SHOULD BE EXCLUDED. IT WAS ALSO DEMONSTRATED THAT IN CH3CN/DMSO MIXTURE, LEU-ENKEPHALIN EXISTS AT PH 5,6 NOT IN THE ZWITTERIONIC FORM BUT IN THE NEUTRAL. THIS WAS CONFIRMED BY IR-FT STUDIES. IN ORDER TO STUDY SIDE- CHAIN CONFORMATION OF TYROSINE CONTAINING PEPTIDES, SEVERAL 17O SELECTIVELY ENRICHED MODEL COMPOUNDS WERE PREPARED. 17O-NMR SPECTROSCOPY WAS PROVED TO BE A VALUABLE TOOL FOR THE INVESTIGATION OF THE IONIZATION STATE OF THE PHENOL GROUP. IR-FT STUDIES REVEALED THAT THE IN PLANE C-O-H BENDING FREQUENCIES ARE VERY SENSITIVE IN HYDROGEN BONDING INTERACTIONS AND DISCRETE HYDROGEN BONDING SPECIES COULD BE IDENTIFIED. IR-FT STUDIES OF LEU-ENKEPHALIN IN H2O HAVE SHOWN THAT TYROSINE PHENOL GROUP IS DIHYDRATED AND NOT INTRAMOLECULARLY HYDROGEN BONDED.","ΣΤΗΝ ΠΑΡΟΥΣΑ ΕΡΓΑΣΙΑ ΠΑΡΑΤΙΘΕΝΤΑΙ ΤΑ ΑΠΟΤΕΛΕΣΜΑΤΑ ΤΩΝ ΜΕΛΕΤΩΝ ΜΕ ΦΑΣΜΑΤΟΣΚΟΠΙΑ 17Ο-NMR, ΤΩΝ ΕΚΛΕΚΤΙΚΑ ΕΜΠΛΟΥΤΙΣΜΕΝΩΝ ΜΕ 17Ο ΕΓΚΕΦΑΛΙΝΩΝ ΣΤΙΣ ΘΕΣΕΙΣ GLY-2, GLY-3 ΚΑΙ ΣΤΟ ΚΑΡΒΟΞΥΛΙΟ. ΜΕΛΕΤΕΣ ΣΕ ΥΔΑΤΙΚΟ ΔΙΑΛΥΜΑ ΚΑΙ ΣΕ ΜΙΓΜΑ CH3CN/DMSO (4:1), ΣΕ ΔΙΑΦΟΡΕΣ ΘΕΡΜΟΚΡΑΣΙΕΣ ΚΑΙ ΡΗ, ΕΔΕΙΞΑΝ ΟΤΙ ΚΑΙ ΤΑ ΔΥΟ ΠΕΠΤΙΔΙΑ ΟΞΥΓΟΝΑ ΔΕΝ ΣΥΜΜΕΤΕΧΟΥΝ ΣΕ ΕΝΔΟΜΟΡΙΑΚΟ ΔΕΣΜΟ ΥΔΡΟΓΟΝΟΥ ΚΑΙ ΣΤΟ ΝΕΡΟ ΥΦΙΣΤΑΝΤΑΙ ΚΥΡΙΩΣ ΣΤΗΝ ΜΟΝΟΕΝΥΔΑΤΩΜΕΝΗ ΤΟΥΣ ΜΟΡΦΗ. ΕΠΟΜΕΝΩΣ ΘΑ ΠΡΕΠΕΙ ΝΑ ΑΠΟΚΛΕΙΣΘΕΙ ΤΟ ΕΝΔΕΧΟΜΕΝΟ ΝΑ ΣΧΗΜΑΤΙΖΕΙ ΤΟ ΜΟΡΙΟ ΜΙΑ Β- ΣΤΡΟΦΗ. ΕΠΙΣΗΣ ΑΠΟΔΕΙΧΘΗΚΕ ΟΤΙ ΣΕ ΜΙΓΜΑ CH3CN/DMSO ΚΑΙ ΣΕ ΡΗ 5,6 Η LEU-ΕΓΚΕΦΑΛΙΝΗ ΥΦΙΣΤΑΤΑΙ ΣΤΗΝ ΟΥΔΕΤΕΡΗ ΜΟΡΦΗ ΚΑΙ ΟΧΙ ΣΤΗ ΔΙΠΟΛΙΚΗ. ΤΟ ΣΥΜΠΕΡΑΣΜΑ ΑΥΤΟ ΕΠΙΒΕΒΑΙΩΘΗΚΕ ΚΑΙ ΜΕ ΜΕΛΕΤΕΣ ΜΕ ΦΑΣΜΑΤΟΣΚΟΠΙΑ ΥΠΕΡΥΘΡΟΥ.ΓΙΑ ΤΗΝ ΠΡΑΓΜΑΤΟΠΟΙΗΣΗ ΜΕΛΕΤΩΝ ΕΠΙ ΤΗΣ ΠΑΡΑΠΛΕΥΡΗΣ ΑΛΥΣΙΔΑΣ ΠΕΠΤΙΔΙΩΝ ΠΟΥ ΠΕΡΙΕΧΟΥΝ ΤΥΡΟΣΙΝΗ: ΕΓΙΝΕ Η ΣΥΝΘΕΣΗ ΠΡΟΤΥΠΩΝ ΕΝΩΣΕΩΝ, ΕΚΛΕΚΤΙΚΑ ΕΜΠΛΟΥΤΙΣΜΕΝΩΝ ΜΕ 17Ο. Η ΦΑΣΜΑΤΟΣΚΟΠΙΑ 17Ο-NMR ΑΠΟΔΕΙΧΘΗΚΕ ΟΤΙ ΕΙΝΑΙ ΜΙΑ ΜΕΘΟΔΟΣ ΕΥΑΙΣΘΗΤΗ ΚΑΙ ΑΚΡΙΒΗΣ ΓΙΑ ΤΗΝ ΔΙΕΡΕΥΝΗΣΗ ΤΗΣ ΚΑΤΑΣΤΑΣΗΣ ΙΟΝΙΣΜΟΥ ΦΑΙΝΟΛΙΚΟΥ ΥΔΡΟΞΥΛΙΟΥ. ΜΕΛΕΤΕΣ IR-FT ΕΔΕΙΞΑΝ ΟΤΙ ΟΙ ΕΝΤΟΣ ΕΠΙΠΕΔΟΥ ΑΠΟΡΡΟΦΗΣΕΙΣ C-O-H ΕΙΝΑΙ ΕΥΑΙΣΘΗΤΕΣ ΣΕ ΑΛΛΗΛΕΠΙΔΡΑΣΕΙΣ ΔΕΣΜΩΝ ΥΔΡΟΓΟΝΟΥ. ΜΕΛΕΤΕΣ IR-FT ΤΗΣ LEU-ΕΓΚΕΦΑΛΙΝΕΣ ΣΕ Η2Ο ΕΔΕΙΞΑΝ ΟΤΙ ΤΟ ΦΑΙΝΟΛΙΚΟ ΥΔΡΟΞΥΛΙΟ ΤΗΣ TYR ΕΙΝΑΙ ΔΙΣΕΝΥΔΑΤΩΜΕΝΟ ΚΑΙ ΔΕΝ ΣΥΜΜΕΤΕΧΕΙ ΣΕ ΕΝΔΟΜΟΡΙΑΚΟ ΔΕΣΜΟ ΥΔΡΟΓΟΝΟΥ."],"dc:identifier":["10.12681/eadd/1502","http://hdl.handle.net/10442/hedi/1502"],"dc:language":["gre"],"dc:publisher":["Πανεπιστήμιο Ιωαννίνων","University of Ioannina"],"dc:subject":["CONFORMATION OF PEPTIDES","ENKEPHALINS","HYDRATION OF PEPTIDES","Hydrogen bonding","Infrared spectroscopy","Nuclear magnetic resonance spectroscopy","Peptides synthesis","SELECTIVE ISOTOPIC ENRICHEMENT","Δεσμοί υδρογόνου","ΔΙΑΜΟΡΦΩΣΗ ΤΩΝ ΠΕΠΤΙΔΙΩΝ","ΕΓΚΕΦΑΛΙΝΕΣ","ΕΚΛΕΚΤΙΚΟΣ ΙΣΟΤΟΠΙΚΟΣ ΕΜΠΛΟΥΤΙΣΜΟΣ","ΕΝΥΔΑΤΩΣΗ ΤΩΝ ΠΕΠΤΙΔΙΩΝ","Πεπτιδική σύνθεση","Φασματοσκοπία πυρηνικού μαγνητικού συντονισμού","Φασματοσκοπία υπερύθρου","Φυσικές Επιστήμες","Natural Sciences","Χημεία","Chemical Sciences"],"dc:title":["ΜΕΛΕΤΗ ΤΗΣ ΔΙΑΜΟΡΦΩΣΗΣ ΚΑΙ ΤΗΣ ΜΟΡΙΑΚΗΣ ΔΥΝΑΜΙΚΗΣ ΤΩΝ ΕΓΚΕΦΑΛΙΝΩΝ ΜΕ ΦΑΣΜΑΤΟΣΚΟΠΙΑ ΠΥΡΗΝΙΚΟΥ ΜΑΓΝΗΤΙΚΟΥ ΣΥΝΤΟΝΙΣΜΟΥ (17Ο-NMR) ΚΑΙ ΥΠΕΡΥΘΡΟΥ...","STUDY OF THE CONFORMATION AND DYNAMIC PROPERTIES OF ENKEPHALINS WITH 17O-NMR AND IR-FT SPECTROSCOPIES CONTRIBUTION TO THE SYNTHESIS OF ISOTOPICALLY LABELLED ANALOGS"],"dc:type":["PhD Thesis"]},"updated_at":"2026-07-24T02:24:59Z"}