{"id":{"repo_id":"greece","oai_identifier":"oai:10442/1475"},"canonical_url":"https://search.dev.ndltd.org/etd/greece/oai:10442/1475","repository":{"repo_id":"greece","name":"Greek National Archive of PhD Theses","base_url":"https://phdtheses.ekt.gr/eadd_oai/request"},"display":{"title":"Αυτοάνοσες εκδηλώσεις και μονοκλωνική εξεργασία στη Β λεμφοκυτταρική νεοπλασία","abstract":"The aim of this study was to investigate the monoclonal or oligoclonal process and autoimmune features of Non-Hodgkin Lymphomas (NHL). The study included 38 patients suffering from NHL and CLL of different disease stages and grades of malignancy. In 72% of the cases of NHL and 31% of the cases of CLL studied, monoclonal or oligoclonal immunoglobulins were detected in the sera. The presence of monoclonal immunoglobulins did not correlate with disease stage or grade of malignancy. It did although correlate with disease remissions or exacerbations indicating that such immunoglobulins could be useful tumor markers. Autoimmune parameters in NHL were not found to be significantly different from these of patients with solid tumors or the normal controls. For this study, a polyclonal antiidiotype was prepared against a monoclonal IgMk rheumatoid factor which was isolated from the type II cryoglobulin of the patient with Sjogren's syndrome. The presence of this idiotype was investigated in the sera of patients with NHL, Waldenstrom's macroglobulinemia and a number of autoimmune diseases. Two out of six patients with Waldenstroms macroglobulinemia were found positive for the presence of the idiotype, whilst all patients with NHL were negative. The idiotype was also found in 62.5% of Sjogren's syndrome and 27% of rheumatoid arthritis patients. No patient with systemic lupus erythematosus neither any normal control were found positive. The presence of the idiotype in Sjogren's syndrome correlated with the monoclonal process and the systemic manifestations of the disease. In conclusion, B-lymphocytes which bear cross-reactive idiotypes could possibly play a role in B-cell neoplasia.","abstract_html":"The aim of this study was to investigate the monoclonal or oligoclonal process and autoimmune features of Non-Hodgkin Lymphomas (NHL). The study included 38 patients suffering from NHL and CLL of different disease stages and grades of malignancy. In 72% of the cases of NHL and 31% of the cases of CLL studied, monoclonal or oligoclonal immunoglobulins were detected in the sera. The presence of monoclonal immunoglobulins did not correlate with disease stage or grade of malignancy. It did although correlate with disease remissions or exacerbations indicating that such immunoglobulins could be useful tumor markers. Autoimmune parameters in NHL were not found to be significantly different from these of patients with solid tumors or the normal controls. For this study, a polyclonal antiidiotype was prepared against a monoclonal IgMk rheumatoid factor which was isolated from the type II cryoglobulin of the patient with Sjogren's syndrome. The presence of this idiotype was investigated in the sera of patients with NHL, Waldenstrom's macroglobulinemia and a number of autoimmune diseases. Two out of six patients with Waldenstroms macroglobulinemia were found positive for the presence of the idiotype, whilst all patients with NHL were negative. The idiotype was also found in 62.5% of Sjogren's syndrome and 27% of rheumatoid arthritis patients. No patient with systemic lupus erythematosus neither any normal control were found positive. The presence of the idiotype in Sjogren's syndrome correlated with the monoclonal process and the systemic manifestations of the disease. In conclusion, B-lymphocytes which bear cross-reactive idiotypes could possibly play a role in B-cell neoplasia.","abstract_has_math":false,"creators":["Katsikis, Panagiotis","Κατσίκης, Παναγιώτης"],"institution":"University of Ioannina","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":1990,"date_issued":"1990","date_published":"1990","updated_at":"2026-07-24T02:24:56Z","subjects":["Αυτοανοσία","Β-Λεμφοκυτταρική νεοπλασία","Ιδιότυποι","Μη Hodgin λέμφωμα","Μονοκλωνικές ανοσοσφαιρίνες","Σύνδρομο Sjogren","Χρόνια λεμφογενής λευχαιμία","Autoimmunity","B-Lymphocytic neoplasia","Idiotypes","Monoclonal immunoglobulins","Sjogren's syndrome","Ιατρική και Επιστήμες Υγείας","Βασική Ιατρική","Κλινική Ιατρική","Medical and Health Sciences","Basic Medicine","Clinical Medicine"],"languages":["gre"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["10.12681/eadd/1475"],"render_values":[{"text":"10.12681/eadd/1475","href":"https://doi.org/10.12681/eadd/1475","code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/10442/hedi/1475","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Katsikis, Panagiotis","Κατσίκης, Παναγιώτης"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["1990"]},{"key":"dc:publisher","label":"Institution","values":["University of Ioannina","Πανεπιστήμιο Ιωαννίνων"]},{"key":"dc:type","label":"Dc Type","values":["PhD Thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Αυτοανοσία","Β-Λεμφοκυτταρική νεοπλασία","Ιδιότυποι","Μη Hodgin λέμφωμα","Μονοκλωνικές ανοσοσφαιρίνες","Σύνδρομο Sjogren","Χρόνια λεμφογενής λευχαιμία","Autoimmunity","B-Lymphocytic neoplasia","Idiotypes","Monoclonal immunoglobulins","Sjogren's syndrome","Ιατρική και Επιστήμες Υγείας","Βασική Ιατρική","Κλινική Ιατρική","Medical and Health Sciences","Basic Medicine","Clinical Medicine"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["gre"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["10.12681/eadd/1475","http://hdl.handle.net/10442/hedi/1475"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["The aim of this study was to investigate the monoclonal or oligoclonal process and autoimmune features of Non-Hodgkin Lymphomas (NHL). The study included 38 patients suffering from NHL and CLL of different disease stages and grades of malignancy. In 72% of the cases of NHL and 31% of the cases of CLL studied, monoclonal or oligoclonal immunoglobulins were detected in the sera. The presence of monoclonal immunoglobulins did not correlate with disease stage or grade of malignancy. It did although correlate with disease remissions or exacerbations indicating that such immunoglobulins could be useful tumor markers. Autoimmune parameters in NHL were not found to be significantly different from these of patients with solid tumors or the normal controls. For this study, a polyclonal antiidiotype was prepared against a monoclonal IgMk rheumatoid factor which was isolated from the type II cryoglobulin of the patient with Sjogren's syndrome. The presence of this idiotype was investigated in the sera of patients with NHL, Waldenstrom's macroglobulinemia and a number of autoimmune diseases. Two out of six patients with Waldenstroms macroglobulinemia were found positive for the presence of the idiotype, whilst all patients with NHL were negative. The idiotype was also found in 62.5% of Sjogren's syndrome and 27% of rheumatoid arthritis patients. No patient with systemic lupus erythematosus neither any normal control were found positive. The presence of the idiotype in Sjogren's syndrome correlated with the monoclonal process and the systemic manifestations of the disease. In conclusion, B-lymphocytes which bear cross-reactive idiotypes could possibly play a role in B-cell neoplasia.","Η μελέτη αυτή έγινε με σκοπό τη διερεύνηση της μονοκλωνικής ή ολιγοκλωνικής εξεργασίας και των αυτοάνοσων φαινομένων στα μη Hodgkin, λεμφώματα (ΜΗΛ). Μελετήθηκαν 25 ασθενείς με ΜΗΛ και ΧΛΛ διαφόρων σταδίων και βαθμών κακοήθειας. Στο 72% των ασθενών με ΜΗΛ και στο 31% των ασθενών με ΧΛΛ βρέθηκαν μονοκλωνικές ανοσοσφαιρίνες στον ορό τους. Η παρουσία της μονοκλωνικότητας στον ορό δεν συσχετίζεται με τα στάδιο της νόσου ή το βαθμό κακοήθειας. Οι μονοκλωνικές ανοσοσφαιρίνες δείχτηκε ότι συσχετίζονται με την κλινική πορεία της νόσου και πιθανά να αποτελούν χρήσιμο κλινικό δείκτη. Στα ΜΗΛ δεν βρέθηκε επίσης αυξημένο ποσοστό αυτοαντισωμάτων σε σύγκριση με ασθενείς με συμπαγείς όγκους και τους φυσιολογικούς μάρτυρες. Επίσης, στη μελέτη αυτή παρασκευάσθηκε πολυκλωνικός αντι-ιδιότυπος κατά μονοκλωνικαύ IgMK ρευματοειδούς παράγοντος που απομονώθηκε από του τύπου II κρυοσφαιρίνη ασθενούς με σύνδρομο Sjogren. Εξετάσθηκαν για την παρουσία του ιδιότυπου στον ορό, ασθενείς με ΜΗΛ, μακροσφαιριναιμία του Waldenstrom και διάφορα αυτοάνοσα νοσήματα. Δύο ασθενείς από τους έξη με μακροσφαιριναιμία ταυ Waldenstrom βρέθηκαν θετικοί για την παρουσία του ιδιοτύπου, ενώ οι ασθενείς με ΜΗΛ ήταν όλοι αρνητικοί. Από τους ασθενείς με σύνδρομο Sjogren 62.5% και ρευματοειδή αρθρίτιδα 27% βρέθηκαν θετικοί για τον ιδιότυπο, ενώ όλοι οι ασθενείς με συστηματικό ερυθηματώδη λύκο και οι φυσιολογικοί μάρτυρες ήταν αρνητικοί. Στο σύνδρομο Sjogren η παρουσία του ιδιότυπου συσχετιζόταν με την παρουσία και τη συστηματική μορφή της νόσου. Συμπερασματικά., Β-λεμφοκύτταρα που φέρουν ιδιότυπους διασταυρούμενης αντίδρασης πιθανά συμμετέχουν στη Β-λεμφοκυτταρική νεοπλασία."]},{"key":"dc:title","label":"Title","values":["Αυτοάνοσες εκδηλώσεις και μονοκλωνική εξεργασία στη Β λεμφοκυτταρική νεοπλασία","Autoimmune features and monoclonal process in B lymphocytic neoplasma"]}]}],"canonical_facts":{"dc:creator":["Katsikis, Panagiotis","Κατσίκης, Παναγιώτης"],"dc:date":["1990"],"dc:description":["The aim of this study was to investigate the monoclonal or oligoclonal process and autoimmune features of Non-Hodgkin Lymphomas (NHL). The study included 38 patients suffering from NHL and CLL of different disease stages and grades of malignancy. In 72% of the cases of NHL and 31% of the cases of CLL studied, monoclonal or oligoclonal immunoglobulins were detected in the sera. The presence of monoclonal immunoglobulins did not correlate with disease stage or grade of malignancy. It did although correlate with disease remissions or exacerbations indicating that such immunoglobulins could be useful tumor markers. Autoimmune parameters in NHL were not found to be significantly different from these of patients with solid tumors or the normal controls. For this study, a polyclonal antiidiotype was prepared against a monoclonal IgMk rheumatoid factor which was isolated from the type II cryoglobulin of the patient with Sjogren's syndrome. The presence of this idiotype was investigated in the sera of patients with NHL, Waldenstrom's macroglobulinemia and a number of autoimmune diseases. Two out of six patients with Waldenstroms macroglobulinemia were found positive for the presence of the idiotype, whilst all patients with NHL were negative. The idiotype was also found in 62.5% of Sjogren's syndrome and 27% of rheumatoid arthritis patients. No patient with systemic lupus erythematosus neither any normal control were found positive. The presence of the idiotype in Sjogren's syndrome correlated with the monoclonal process and the systemic manifestations of the disease. In conclusion, B-lymphocytes which bear cross-reactive idiotypes could possibly play a role in B-cell neoplasia.","Η μελέτη αυτή έγινε με σκοπό τη διερεύνηση της μονοκλωνικής ή ολιγοκλωνικής εξεργασίας και των αυτοάνοσων φαινομένων στα μη Hodgkin, λεμφώματα (ΜΗΛ). Μελετήθηκαν 25 ασθενείς με ΜΗΛ και ΧΛΛ διαφόρων σταδίων και βαθμών κακοήθειας. Στο 72% των ασθενών με ΜΗΛ και στο 31% των ασθενών με ΧΛΛ βρέθηκαν μονοκλωνικές ανοσοσφαιρίνες στον ορό τους. Η παρουσία της μονοκλωνικότητας στον ορό δεν συσχετίζεται με τα στάδιο της νόσου ή το βαθμό κακοήθειας. Οι μονοκλωνικές ανοσοσφαιρίνες δείχτηκε ότι συσχετίζονται με την κλινική πορεία της νόσου και πιθανά να αποτελούν χρήσιμο κλινικό δείκτη. Στα ΜΗΛ δεν βρέθηκε επίσης αυξημένο ποσοστό αυτοαντισωμάτων σε σύγκριση με ασθενείς με συμπαγείς όγκους και τους φυσιολογικούς μάρτυρες. Επίσης, στη μελέτη αυτή παρασκευάσθηκε πολυκλωνικός αντι-ιδιότυπος κατά μονοκλωνικαύ IgMK ρευματοειδούς παράγοντος που απομονώθηκε από του τύπου II κρυοσφαιρίνη ασθενούς με σύνδρομο Sjogren. Εξετάσθηκαν για την παρουσία του ιδιότυπου στον ορό, ασθενείς με ΜΗΛ, μακροσφαιριναιμία του Waldenstrom και διάφορα αυτοάνοσα νοσήματα. Δύο ασθενείς από τους έξη με μακροσφαιριναιμία ταυ Waldenstrom βρέθηκαν θετικοί για την παρουσία του ιδιοτύπου, ενώ οι ασθενείς με ΜΗΛ ήταν όλοι αρνητικοί. Από τους ασθενείς με σύνδρομο Sjogren 62.5% και ρευματοειδή αρθρίτιδα 27% βρέθηκαν θετικοί για τον ιδιότυπο, ενώ όλοι οι ασθενείς με συστηματικό ερυθηματώδη λύκο και οι φυσιολογικοί μάρτυρες ήταν αρνητικοί. Στο σύνδρομο Sjogren η παρουσία του ιδιότυπου συσχετιζόταν με την παρουσία και τη συστηματική μορφή της νόσου. Συμπερασματικά., Β-λεμφοκύτταρα που φέρουν ιδιότυπους διασταυρούμενης αντίδρασης πιθανά συμμετέχουν στη Β-λεμφοκυτταρική νεοπλασία."],"dc:identifier":["10.12681/eadd/1475","http://hdl.handle.net/10442/hedi/1475"],"dc:language":["gre"],"dc:publisher":["University of Ioannina","Πανεπιστήμιο Ιωαννίνων"],"dc:subject":["Αυτοανοσία","Β-Λεμφοκυτταρική νεοπλασία","Ιδιότυποι","Μη Hodgin λέμφωμα","Μονοκλωνικές ανοσοσφαιρίνες","Σύνδρομο Sjogren","Χρόνια λεμφογενής λευχαιμία","Autoimmunity","B-Lymphocytic neoplasia","Idiotypes","Monoclonal immunoglobulins","Sjogren's syndrome","Ιατρική και Επιστήμες Υγείας","Βασική Ιατρική","Κλινική Ιατρική","Medical and Health Sciences","Basic Medicine","Clinical Medicine"],"dc:title":["Αυτοάνοσες εκδηλώσεις και μονοκλωνική εξεργασία στη Β λεμφοκυτταρική νεοπλασία","Autoimmune features and monoclonal process in B lymphocytic neoplasma"],"dc:type":["PhD Thesis"]},"updated_at":"2026-07-24T02:24:56Z"}