{"id":{"repo_id":"greece","oai_identifier":"oai:10442/1435"},"canonical_url":"https://search.dev.ndltd.org/etd/greece/oai:10442/1435","repository":{"repo_id":"greece","name":"Greek National Archive of PhD Theses","base_url":"https://phdtheses.ekt.gr/eadd_oai/request"},"display":{"title":"Συσχέτιση των αντιγόνων ιστοσυμβατότητας (HLA) με την πέμφιγα","abstract":"THIS STUDY IS BASED ON 50 GREEK PEMPHIGUS PATIENTS. OUT OF THEM 48 SUFFERED FROM PEMPHIGUS VULGARIS AND THE REMAINING 2 FROM PEMPHIGUS FOLIACEUS. A TOTAL OF 61 ANTIGENS HLA-A,B,C,DR WAS DETERMINED AND THEIR RELATIONSHIP TO THE DISEASE WAS INVESTIGATED . 550 HEALTHY CONTROL GREEK PERSONS WERE USED 450 FOR THE LOCUS HLA-A AND HLA-B AND 100 FOR THE LOCUS HLA-DR. THE ANTIGEN DETERMINATION WAS PERFORMED BY MEANS OF THE TERASAKI LYMPHOCYTOTOXICITY TEST AND 180 ANTI-HLA SERA WERE EMPLOYED FOR EVERY INDIVIDUAL INCLUDED IN THIS STUDY. THE GENETICALLY PREDETERMINED SUSCEPTIBILITY TO THE DISEASE WAS CONFIRMED BY THE PRESENCE OF HLA-DR4GENE CHARACTERIZING THE DISEASE. THOSE RELATION WITH THE DISEASE OBSERVED WITHTHE GENES HLA-DR3, HLA- DR6 AND HLA-DR7. THE ANTIGEN HLA-A11 PRESENTS A STATISTICALLY SIGNIFICANT INCREASE. THE ANTIGEN HLA-B27 PRESENTS A DECREASE VS CONTROL GROUP AND IT PROBABLY PLAYS A PROTECTIVE ROLE AGAINST THE DISEASE HLA-BW38 PRESENTS AN INCREASE WHICH IS STATISTICALLY NON SIGNIFICANT.","abstract_html":"THIS STUDY IS BASED ON 50 GREEK PEMPHIGUS PATIENTS. OUT OF THEM 48 SUFFERED FROM PEMPHIGUS VULGARIS AND THE REMAINING 2 FROM PEMPHIGUS FOLIACEUS. A TOTAL OF 61 ANTIGENS HLA-A,B,C,DR WAS DETERMINED AND THEIR RELATIONSHIP TO THE DISEASE WAS INVESTIGATED . 550 HEALTHY CONTROL GREEK PERSONS WERE USED 450 FOR THE LOCUS HLA-A AND HLA-B AND 100 FOR THE LOCUS HLA-DR. THE ANTIGEN DETERMINATION WAS PERFORMED BY MEANS OF THE TERASAKI LYMPHOCYTOTOXICITY TEST AND 180 ANTI-HLA SERA WERE EMPLOYED FOR EVERY INDIVIDUAL INCLUDED IN THIS STUDY. THE GENETICALLY PREDETERMINED SUSCEPTIBILITY TO THE DISEASE WAS CONFIRMED BY THE PRESENCE OF HLA-DR4GENE CHARACTERIZING THE DISEASE. THOSE RELATION WITH THE DISEASE OBSERVED WITHTHE GENES HLA-DR3, HLA- DR6 AND HLA-DR7. THE ANTIGEN HLA-A11 PRESENTS A STATISTICALLY SIGNIFICANT INCREASE. THE ANTIGEN HLA-B27 PRESENTS A DECREASE VS CONTROL GROUP AND IT PROBABLY PLAYS A PROTECTIVE ROLE AGAINST THE DISEASE HLA-BW38 PRESENTS AN INCREASE WHICH IS STATISTICALLY NON SIGNIFICANT.","abstract_has_math":false,"creators":["Σταύρου, Βίκτωρ-Άρης"],"institution":"National and Kapodistrian University of Athens","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":1988,"date_issued":"1988","date_published":"1988","updated_at":"2026-07-24T02:24:56Z","subjects":["Αντιγόνα ιστοσυμβατότητας","Πέμφιγα","HLA","Major histocompatibility complex (MHC)","Pemphigus","Ιατρική και Επιστήμες Υγείας","Κλινική Ιατρική","Medical and Health Sciences","Clinical Medicine"],"languages":["gre"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["10.12681/eadd/1435"],"render_values":[{"text":"10.12681/eadd/1435","href":"https://doi.org/10.12681/eadd/1435","code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/10442/hedi/1435","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Σταύρου, Βίκτωρ-Άρης"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["1988"]},{"key":"dc:publisher","label":"Institution","values":["National and Kapodistrian University of Athens","Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ)"]},{"key":"dc:type","label":"Dc Type","values":["PhD Thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Αντιγόνα ιστοσυμβατότητας","Πέμφιγα","HLA","Major histocompatibility complex (MHC)","Pemphigus","Ιατρική και Επιστήμες Υγείας","Κλινική Ιατρική","Medical and Health Sciences","Clinical Medicine"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["gre"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["10.12681/eadd/1435","http://hdl.handle.net/10442/hedi/1435"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["THIS STUDY IS BASED ON 50 GREEK PEMPHIGUS PATIENTS. OUT OF THEM 48 SUFFERED FROM PEMPHIGUS VULGARIS AND THE REMAINING 2 FROM PEMPHIGUS FOLIACEUS. A TOTAL OF 61 ANTIGENS HLA-A,B,C,DR WAS DETERMINED AND THEIR RELATIONSHIP TO THE DISEASE WAS INVESTIGATED . 550 HEALTHY CONTROL GREEK PERSONS WERE USED 450 FOR THE LOCUS HLA-A AND HLA-B AND 100 FOR THE LOCUS HLA-DR. THE ANTIGEN DETERMINATION WAS PERFORMED BY MEANS OF THE TERASAKI LYMPHOCYTOTOXICITY TEST AND 180 ANTI-HLA SERA WERE EMPLOYED FOR EVERY INDIVIDUAL INCLUDED IN THIS STUDY. THE GENETICALLY PREDETERMINED SUSCEPTIBILITY TO THE DISEASE WAS CONFIRMED BY THE PRESENCE OF HLA-DR4GENE CHARACTERIZING THE DISEASE. THOSE RELATION WITH THE DISEASE OBSERVED WITHTHE GENES HLA-DR3, HLA- DR6 AND HLA-DR7. THE ANTIGEN HLA-A11 PRESENTS A STATISTICALLY SIGNIFICANT INCREASE. THE ANTIGEN HLA-B27 PRESENTS A DECREASE VS CONTROL GROUP AND IT PROBABLY PLAYS A PROTECTIVE ROLE AGAINST THE DISEASE HLA-BW38 PRESENTS AN INCREASE WHICH IS STATISTICALLY NON SIGNIFICANT.","ΤΟ ΥΛΙΚΟ ΤΗΣ ΜΕΛΕΤΗΣ ΑΠΟΤΕΛΕΣΑΝ 50 ΑΣΘΕΝΕΙΣ ΜΕ ΠΕΜΦΙΓΑ ΑΠΟ ΤΟΥΣ ΟΠΟΙΟΥΣ ΟΙ 48 ΕΙΧΑΝ ΚΟΙΝΗ ΠΕΜΦΙΓΑ ΚΑΙ ΟΙ 2 ΦΥΛΛΩΔΗ ΠΕΜΦΙΓΑ. ΠΡΟΣΔΙΟΡΙΣΤΗΚΑΝ 64 ΣΥΝΟΛΙΚΑ ΑΝΤΙΓΟΝΑ ΤΟΥ ΣΥΣΤΗΜΑΤΟΣ HLA,A,B,C, DR ΚΑΙ ΜΕΛΕΤΗΘΗΚΕ Η ΣΧΕΣΗ ΤΟΥΣ ΜΕ ΤΗ ΝΟΣΟ. ΧΡΗΣΙΜΟΠΟΙΗΘΗΚΑΝ ΣΥΝΟΛΙΚΑ 550 ΥΓΙΕΙΣ ΜΑΡΤΥΡΕΣ (450 ΓΙΑ ΤΟΥΣ ΤΥΠΟΥΣ HLA-A ΚΑΙ HLA-B ΚΑΙ100 ΓΙΑ ΤΟΝ ΤΥΠΟ HLA-DR. Ο ΠΡΟΣΔΙΟΡΙΣΜΟΣ ΤΩΝ ΑΝΤΙΓΟΝΩΝ ΕΓΙΝΕ ΜΕ ΤΗ ΜΙΚΡΟΛΕΜΦΟΚΥΤΤΑΡΟΤΟΞΙΚΗ ΔΟΚΙΜΑΣΙΑ TERASAKI ΚΑΙ ΧΡΗΣΙΜΟΠΟΙΗΘΗΚΑΝ ΣΥΝΟΛΙΚΑ 120 ΟΡΟΙ ΓΙΑ ΚΑΘΕΑΤΟΜΟ ΓΙΑ ΤΟΝ ΠΡΟΣΔΙΟΡΙΣΜΟ ΤΩΝ HLA-A ΚΑΙ HLA-B ΑΝΤΙΓΟΝΩΝ ΚΑΙ 60 ΟΡΟΙ ΓΙΑ ΚΑΘΕ ΑΤΟΜΟ ΓΙΑ ΤΟΝ ΠΡΟΣΔΙΟΡΙΣΜΟ ΤΩΝ HLA-DR. ΕΠΙΒΕΒΑΙΩΘΗΚΕ Η ΓΕΝΕΤΙΚΗ ΕΥΠΑΘΕΙΑ ΣΤΗ ΝΟΣΟ ΠΟΥ ΧΑΡΑΚΤΗΡΙΖΕΤΑΙ ΑΠΟ ΤΗΝ ΥΠΑΡΞΗ ΣΤΟΥΣ ΑΣΘΕΝΕΙΣ ΤΟΥ ΓΟΝΟΥ HLA-DR4. ΑΣΘΕΝΗ ΣΧΕΣΗ ΜΕ ΤΗ ΝΟΣΟ ΠΑΡΟΥΣΙΑΖΟΥΝ ΚΑΙ ΤΑ ΑΝΤΙΓΟΝΑ HLA -DR3, HLA-DR6 ΚΑΙ HLA-DR7. ΣΗΜΑΝΤΙΚΗ ΑΥΞΗΣΗ ΠΑΡΟΥΣΙΑΣΕ ΤΟ ΑΝΤΙΓΟΝΟ HLA-A11 ΕΝΩ ΤΟ HLA-B27 ΕΜΦΑΝΙΣΕ ΜΕΙΩΣΗ ΣΕ ΣΧΕΣΗ ΜΕ ΤΟΥΣ ΜΑΡΤΥΡΕΣ ΠΡΑΓΜΑ ΠΟΥ ΔΕΙΧΝΕΙ ΟΤΙ ΕΝΔΕΧΟΜΕΝΑ ΠΑΙΖΕΙ ΚΑΠΟΙΟ ΠΡΟΣΤΑΤΕΥΤΙΚΟ ΡΟΛΟ ΑΠΕΝΑΝΤΙ ΣΤΗΝ ΝΟΣΟ."]},{"key":"dc:title","label":"Title","values":["Συσχέτιση των αντιγόνων ιστοσυμβατότητας (HLA) με την πέμφιγα","Major histocompatibility complex and pemphigus"]}]}],"canonical_facts":{"dc:creator":["Σταύρου, Βίκτωρ-Άρης"],"dc:date":["1988"],"dc:description":["THIS STUDY IS BASED ON 50 GREEK PEMPHIGUS PATIENTS. OUT OF THEM 48 SUFFERED FROM PEMPHIGUS VULGARIS AND THE REMAINING 2 FROM PEMPHIGUS FOLIACEUS. A TOTAL OF 61 ANTIGENS HLA-A,B,C,DR WAS DETERMINED AND THEIR RELATIONSHIP TO THE DISEASE WAS INVESTIGATED . 550 HEALTHY CONTROL GREEK PERSONS WERE USED 450 FOR THE LOCUS HLA-A AND HLA-B AND 100 FOR THE LOCUS HLA-DR. THE ANTIGEN DETERMINATION WAS PERFORMED BY MEANS OF THE TERASAKI LYMPHOCYTOTOXICITY TEST AND 180 ANTI-HLA SERA WERE EMPLOYED FOR EVERY INDIVIDUAL INCLUDED IN THIS STUDY. THE GENETICALLY PREDETERMINED SUSCEPTIBILITY TO THE DISEASE WAS CONFIRMED BY THE PRESENCE OF HLA-DR4GENE CHARACTERIZING THE DISEASE. THOSE RELATION WITH THE DISEASE OBSERVED WITHTHE GENES HLA-DR3, HLA- DR6 AND HLA-DR7. THE ANTIGEN HLA-A11 PRESENTS A STATISTICALLY SIGNIFICANT INCREASE. THE ANTIGEN HLA-B27 PRESENTS A DECREASE VS CONTROL GROUP AND IT PROBABLY PLAYS A PROTECTIVE ROLE AGAINST THE DISEASE HLA-BW38 PRESENTS AN INCREASE WHICH IS STATISTICALLY NON SIGNIFICANT.","ΤΟ ΥΛΙΚΟ ΤΗΣ ΜΕΛΕΤΗΣ ΑΠΟΤΕΛΕΣΑΝ 50 ΑΣΘΕΝΕΙΣ ΜΕ ΠΕΜΦΙΓΑ ΑΠΟ ΤΟΥΣ ΟΠΟΙΟΥΣ ΟΙ 48 ΕΙΧΑΝ ΚΟΙΝΗ ΠΕΜΦΙΓΑ ΚΑΙ ΟΙ 2 ΦΥΛΛΩΔΗ ΠΕΜΦΙΓΑ. ΠΡΟΣΔΙΟΡΙΣΤΗΚΑΝ 64 ΣΥΝΟΛΙΚΑ ΑΝΤΙΓΟΝΑ ΤΟΥ ΣΥΣΤΗΜΑΤΟΣ HLA,A,B,C, DR ΚΑΙ ΜΕΛΕΤΗΘΗΚΕ Η ΣΧΕΣΗ ΤΟΥΣ ΜΕ ΤΗ ΝΟΣΟ. ΧΡΗΣΙΜΟΠΟΙΗΘΗΚΑΝ ΣΥΝΟΛΙΚΑ 550 ΥΓΙΕΙΣ ΜΑΡΤΥΡΕΣ (450 ΓΙΑ ΤΟΥΣ ΤΥΠΟΥΣ HLA-A ΚΑΙ HLA-B ΚΑΙ100 ΓΙΑ ΤΟΝ ΤΥΠΟ HLA-DR. Ο ΠΡΟΣΔΙΟΡΙΣΜΟΣ ΤΩΝ ΑΝΤΙΓΟΝΩΝ ΕΓΙΝΕ ΜΕ ΤΗ ΜΙΚΡΟΛΕΜΦΟΚΥΤΤΑΡΟΤΟΞΙΚΗ ΔΟΚΙΜΑΣΙΑ TERASAKI ΚΑΙ ΧΡΗΣΙΜΟΠΟΙΗΘΗΚΑΝ ΣΥΝΟΛΙΚΑ 120 ΟΡΟΙ ΓΙΑ ΚΑΘΕΑΤΟΜΟ ΓΙΑ ΤΟΝ ΠΡΟΣΔΙΟΡΙΣΜΟ ΤΩΝ HLA-A ΚΑΙ HLA-B ΑΝΤΙΓΟΝΩΝ ΚΑΙ 60 ΟΡΟΙ ΓΙΑ ΚΑΘΕ ΑΤΟΜΟ ΓΙΑ ΤΟΝ ΠΡΟΣΔΙΟΡΙΣΜΟ ΤΩΝ HLA-DR. ΕΠΙΒΕΒΑΙΩΘΗΚΕ Η ΓΕΝΕΤΙΚΗ ΕΥΠΑΘΕΙΑ ΣΤΗ ΝΟΣΟ ΠΟΥ ΧΑΡΑΚΤΗΡΙΖΕΤΑΙ ΑΠΟ ΤΗΝ ΥΠΑΡΞΗ ΣΤΟΥΣ ΑΣΘΕΝΕΙΣ ΤΟΥ ΓΟΝΟΥ HLA-DR4. ΑΣΘΕΝΗ ΣΧΕΣΗ ΜΕ ΤΗ ΝΟΣΟ ΠΑΡΟΥΣΙΑΖΟΥΝ ΚΑΙ ΤΑ ΑΝΤΙΓΟΝΑ HLA -DR3, HLA-DR6 ΚΑΙ HLA-DR7. ΣΗΜΑΝΤΙΚΗ ΑΥΞΗΣΗ ΠΑΡΟΥΣΙΑΣΕ ΤΟ ΑΝΤΙΓΟΝΟ HLA-A11 ΕΝΩ ΤΟ HLA-B27 ΕΜΦΑΝΙΣΕ ΜΕΙΩΣΗ ΣΕ ΣΧΕΣΗ ΜΕ ΤΟΥΣ ΜΑΡΤΥΡΕΣ ΠΡΑΓΜΑ ΠΟΥ ΔΕΙΧΝΕΙ ΟΤΙ ΕΝΔΕΧΟΜΕΝΑ ΠΑΙΖΕΙ ΚΑΠΟΙΟ ΠΡΟΣΤΑΤΕΥΤΙΚΟ ΡΟΛΟ ΑΠΕΝΑΝΤΙ ΣΤΗΝ ΝΟΣΟ."],"dc:identifier":["10.12681/eadd/1435","http://hdl.handle.net/10442/hedi/1435"],"dc:language":["gre"],"dc:publisher":["National and Kapodistrian University of Athens","Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ)"],"dc:subject":["Αντιγόνα ιστοσυμβατότητας","Πέμφιγα","HLA","Major histocompatibility complex (MHC)","Pemphigus","Ιατρική και Επιστήμες Υγείας","Κλινική Ιατρική","Medical and Health Sciences","Clinical Medicine"],"dc:title":["Συσχέτιση των αντιγόνων ιστοσυμβατότητας (HLA) με την πέμφιγα","Major histocompatibility complex and pemphigus"],"dc:type":["PhD Thesis"]},"updated_at":"2026-07-24T02:24:56Z"}