Κλινική και ανοσολογική μελέτη της πνευμονικής ασπεργιλλώσεως από τον ασπέργιλλο fumigatus

792 pulmonary patients and 130 healthy controls were studied in order to detect the presence of pulmonary aspergillosis. Diagnosis was based on the combination of the classic clinical and laboratory criteria with the results of the immunologic methods of counterimmunoelectrophoresis and immunoenzymatic reaction of chymotrypsine. The results and conclusions are summarized as following: - 46 patients (5.8%) were found to have pulmonary aspergillosis: 15 Aspergillomas, 10 Allergic bronchopulmonary aspergillosis and 21 unclassified forms. This last form may be caused by: a) an early stage of a chronic form of aspergillosis that could later end up in one of the classic forms of the disease. b) untypical form of apsergillosis that is known to affect patients with immunosupression. - 573 patients (72.35%) had arcs on the counterimmunoelectrophoresis without any clinical or laboratory indication of pulmonary aspergillosis. - 173 patients (21.84%) and all healthy controls had not arcs on counterimmunoelectrophoresis. Immunoenzymatic reaction of chymotrypsine is thought to be specific for aspergillosis from aspergillus fumigatus. Its contribution is great, because it establishes the diagnosis with certainty in suspected cases and it detects patients with unclassified forms who have insufficient clinical and laboratory findings. If this method is negative and there is clinical or radiologic suspicion of aspergillosis, antibodies against other Aspergillus species should looked for. Counterimmunoelectrophoresis is a very sensitive method, since all our patients with aspergillosis (except for one) gave 1-6 arcs. It is superior to the other methods in use as a screening test. It is also very useful not only for the establishment of the diagnosis but also for epidemiologic studies. Patients sera that had many arcs gave in a great percentage positive the immunoenzymatic reaction of chymotrypsine. The methodology of our study is thought to be superior to the ones of similar studies regarding the diagnosis and the immunologic study of aspergillosis. Methods of indirect immunofluorescence and counterimmunoelectrophoresis are not particularly helpful in the evaluation of clinical symptomatology of aspergillosis.

Grantor dc:publisher

National and Kapodistrian University of Athens

Year dc:date

1982

Authors dc:creator

• Bouras, Athanasios
• Μπούρας, Αθανάσιος

• Ανοσολογία ασπεργιλλώσεως
• Επιδημιολογία ασπεργιλλώσεως
• Κλινική εικόνα βρογχοπνευμονικής ασπεργιλλώσεως
• Πνευμονική ασπεργίλλωση
• Allergic bronchopulmonary aspergillosis
• Invasive and saprophytic aspergillosis
• Pulmonary aspergilloma
• Ιατρική και Επιστήμες Υγείας
• Κλινική Ιατρική
• Medical and Health Sciences
• Clinical Medicine

Language dc:language

gre

Identifier

10.12681/eadd/1411

OAI identifier oai:identifier

oai:10442/1411